Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects

Journal of Medicinal Chemistry

Volumn 45, Issue 16, 2002, Pages 3549-3557

  Hamilton, Gregory S ^a   Wu, Yong Qian ^a   Limburg, David C ^a   Wilkinson, Douglas E ^a   Vaal, Mark J ^a   Li, Jia He ^a   Thomas, Christine ^a   Huang, Wei ^a   Sauer, Hansjorg ^a   Ross, Douglas T ^a   Soni, Raj ^a   Chen, Yi ^a   Guo, Hongshi ^a   Howorth, Pamela ^a   Valentine, Heather ^a   Liang, Shi ^a   Spicer, Dawn ^a   Fuller, Mike ^a   Steiner, Joseph P ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; CYCLOPHILIN; NEUROPROTECTIVE AGENT; RAPAMYCIN; TACROLIMUS;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NERVE FIBER GROWTH; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ADMINISTRATION, ORAL; AMIDES; ANIMALS; CORPUS STRIATUM; DOPAMINE AGENTS; IMMUNOHISTOCHEMISTRY; LIGANDS; MICE; MOLECULAR MIMICRY; NERVE REGENERATION; NEURITES; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE, SECONDARY; PIPECOLIC ACIDS; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANTIA NIGRA; SULFHYDRYL COMPOUNDS; TACROLIMUS BINDING PROTEIN 1A; TYROSINE 3-MONOOXYGENASE;

EID: 0036682173     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010556c     Document Type: Article

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