ING1 isoforms differentially affect apoptosis in a cell age-dependent manner

Cancer Research

Volumn 62, Issue 15, 2002, Pages 4445-4452

  Vieyra, Diego ^a   Toyama, Tatsuya ^b   Hara, Yasuo ^a,b   Boland, Donna ^a,c   Johnston, Randal ^a,d   Riabowol, Karl ^a,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c Southern Alberta Cancer Research Institute   (Canada)

^d Genome Prairie   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; ISOPROTEIN; PROTEIN P33 ING1B; PROTEIN P47 ING1A; UNCLASSIFIED DRUG;

AGE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; SENESCENCE; TUMOR SUPPRESSOR GENE; ULTRAVIOLET IRRADIATION;

APOPTOSIS; CELL AGING; CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMATIN; DNA-BINDING PROTEINS; GENES, TUMOR SUPPRESSOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; PROTEINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0036681999     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation
2. Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)
3. Suppression of ING1 expression in sporadic breast cancer
4. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: Characterization of tissue-specific ING1 transcripts and a homologue gene
5. Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer
6. Decreased expression of p33ING1 mRNA in lymphoid malignancies
7. The tumor suppressor ING1: Structure and function
8. Correction and addition to ING1 sequences
9. Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor
10. A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis
11. UV-induced binding of ING1 to PCNA regulates the induction of apoptosis
12. UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences
13. Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis in gliomas
14. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control
15. The tumor suppressor candidate p33(ING1) mediates repair of UV-damaged DNA
16. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved
17. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities
18. Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression
19. Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex
20. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC 1 transcriptional corepressor complex
21. Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity
22. A DNA damage signal is required for p53 to activate gadd45
23. Acetylation of histones and transcription-related factors
24. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
25. Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
26. Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts
27. Increased activity of p53 in senescing fibroblasts
28. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
29. A panel of CAb antibodies recognize endogenous and ectopically expressed ING1 protein
30. Monitoring mRNA expression by polymerase chain reaction: The "primer-dropping" method
31. Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis
32. Preparation of radiolabeled DNA and RNA probes
33. Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest
34. 2 response of normal human fibroblasts
35. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
36. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
37. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53