Suppression of synaptotagmin II restrains phorbolester-induced downregulation of protein kinase Cα by diverting the kinase from a degradative pathway to the recycling endocytic compartment

Journal of Cell Science

Volumn 115, Issue 15, 2002, Pages 3083-3092

  Peng, Ze ^a   Grimberg, Elena ^a   Sagi Eisenberg, Ronit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Endosome; Mast cells; Protein kinase C; Synaptotagmin; TPA

Indexed keywords

COMPLEMENTARY DNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; SYNAPTOTAGMIN; SYNAPTOTAGMIN II; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; ENZYME INHIBITOR; MULTIENZYME COMPLEX; NERVE PROTEIN; PHORBOL ESTER; PROTEASOME; PROTEIN KINASE C; SYT2 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DNA TRANSFECTION; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; ENZYME DEGRADATION; ENZYME REPRESSION; HALF LIFE TIME; MAST CELL LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; RECYCLING; SECRETORY GRANULE; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; MAST CELL; METABOLISM; NUCLEIC ACID PROBE; PHYSIOLOGY; PROTEIN TRANSPORT; SECRETORY VESICLE;

ANIMALIA;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); CELL COMPARTMENTATION; CELL MEMBRANE; CYSTEINE ENDOPEPTIDASES; CYTOSOL; DOWN-REGULATION; ENDOCYTOSIS; ENDOSOMES; ENZYME INHIBITORS; MAST CELLS; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; PHORBOL ESTERS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN TRANSPORT; RATS; SECRETORY VESICLES; SIGNAL TRANSDUCTION; SYNAPTOTAGMIN II; TUMOR CELLS, CULTURED;

EID: 0036676874     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Genetic and molecular analysis of the synaptotagmin family
2. How do Rab proteins function in membrane traffic?
3. 2+-triggered exocytosis of lysosomes in mast cells
4. Synaptotagmin regulates mast cell functions
5. SNAREs and the specificity of transport vesicle targeting
6. Synaptotagmin: A calcium sensor on the synaptic vesicle surface
7. Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3
8. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
9. Differential down regulation of protein kinase C selectively effects IgE-dependent exocytosis and inositol trisphosphate formation
10. 2+ sensor for transmitter release at a central synapse
11. Down-regulation of MET, the receptor for hepatocyte growth factor
12. Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes
13. Differential down regulation of protein kinase C isozymes
14. Membrane transport: Tethers and TRAPPs
15. Activation of protein kinase C triggers its ubiquitination and degradation
16. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors
17. The extended protein kinase C superfamily
18. Targeting of protein kinase C alpha to caveolae
19. Studies and perspectives of protein kinase C
20. Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells
21. Rapid microassay for protein kinase C translocation in Swiss 3T3 cells
22. Protein kinase C (alpha) actively down-regulates through caveolae-dependent traffic to an endosomal compartment
23. Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells
24. Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments
25. Protein kinase C, a coupling element between stimulus and secretion of basophils
26. Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukemia cells
27. The receptor recycling pathway contains two distinct populations of early endosomes with different sorting functions
28. Synaptotagmins: C2-domain proteins that regulate membrane traffic
29. Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway
30. The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand
31. Stimulated release of fluorescently labeled IgE fragments that efficiently accumulate in secretory granules after endocytosis in RBL-2H3 mast cells