Genetic and molecular analysis of the synaptotagmin family

Cellular and Molecular Life Sciences

Volumn 58, Issue 3, 2001, Pages 393-402

  Adolfsen, B ^a   Littleton, J T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Endocytosis; Exocytosis; Neurotransmitter release; SNARE; Synapse; Synaptotagmin

Indexed keywords

CALCIUM BINDING PROTEIN; NEUROTRANSMITTER; SNARE PROTEIN; SYNAPTOTAGMIN;

ANIMAL CELL; CALCIUM TRANSPORT; CELL ENERGY; CELL FUSION; CELL MEMBRANE; CONTROLLED STUDY; ENDOCYTOSIS; EUKARYOTE; EXOCYTOSIS; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MOLECULAR GENETICS; NEUROTRANSMISSION; NONHUMAN; PHOSPHOLIPID BILAYER; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION;

ANIMALIA; EUKARYOTA;

EID: 0035078239     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000865     Document Type: Review

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7. Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient calcium increases and by cAMP
8. Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission
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10. Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly
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14. Compartmental specificity of cellular membrane fusion encoded iA SNARE proteins
15. Contributions of new impregnation methods and freeze etching to the problems of synaptic fine structure
16. Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release
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24. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
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26. Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III: Implications for calcium-independent SNARE complex interaction
27. Synaptotagmin: A calcium sensor on the synaptic vesicle surface
28. A single C2 domain from synaptotagmin I is sufficient for high affinity calcium /phospolipid binding
29. Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
30. Kinetics of synaptotagmin responses to calcium and assembly with the core SNARE complex onto membranes
31. Oligomerization of the C2B domain of synaptotagmin I is essential for calcium-triggered exocytosis
32. Distinct calcium-dependent properties of the first and second C2-domains of synaptotagmin I
33. Calcium-dependent oligomerization of synaptotagmins I and II: Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium
34. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
35. A novel function for the second C2 domain of synaptotagmin: Calcium-triggered dimerization
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37. The C terminus of SNAP25 is essential for calcium-dependent binding of synaptotagmin to SNARE complexes
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39. Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin
40. Interaction of the synprint site of N-type calcium channels with the C2B domain of synaptotagmin I
41. The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen
42. HPC-I is associated with synaptotagmin and the ω-conotoxin receptor
43. Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltagesensitive sodium channels
44. Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling
45. Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo
46. A possible docking and fusion particle for synaptic transmission
47. Interaction of synaptotagmin with the cytoplasmic domains of neurexins
48. Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin
49. Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin 11
50. SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms
51. Regulation of AP-2-synaptotagmin interaction by inositol high polyphosphates
52. Synaptic function is impaired but not eliminated in C. elegans mutants lacking Synaptotagmin
53. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
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55. Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in calcium-activated neurotransmitter release
56. Calcium dependence of neurotransmitter release and rate of sponataneous vesicle fusions are altered in Drosophila synaptotagmin mutants
57. The effect on synaptic physiology of synaptolagmin mutalions in Drosophila
58. Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila
59. Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis
60. Role of the C2A domain of synaptotagmin in transmitter release as determined by specific antibody injection into the squid giant synapse preterminal
61. Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse pre-terminal
62. Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells
63. Calcium-dependent and -independent activities of neural and non-neural synaptotagmins
64. A third synaptotagmin gene, Syt3, in the mouse
65. Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells
66. A novel seizure-induced synaptotagmin gene identified by differential display
67. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog
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74. Synaptotagmin IV is present at the Golgi and distal parts of neurites
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78. Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain
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80. Phospholipid composition dependence of calcium-dependent phospholipid binding to the C2A domain of synaptotagmin IV
81. Deficits in memory and motor performance in synaptotagmin IV mutant mice