Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats

Clinical Science

Volumn 103, Issue SUPPL. 48, 2002, Pages

  Sakai, Satoshi ^a   Miyauchi, Takashi ^a   Irukayama Tomobe, Yoko ^a   Ogata, Takehiro ^a   Goto, Katsutoshi ^a   Yamaguchi, Iwao ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cardiac hypertrophy; Endothelin 1; Peroxisome proliferator activated receptor ; Transcription factor

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CELL NUCLEUS RECEPTOR; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; MESSENGER RNA; MOLECULAR MARKER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; THIAZOLIDINE DERIVATIVE; TRANSCRIPTION FACTOR AP 1; TROGLITAZONE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA CLAMPING; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE; GENE CONTROL; GENE EXPRESSION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE HYPERTROPHY; HYPERVOLEMIA; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RAT;

EID: 0036670238     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs103s016s     Document Type: Conference Paper

References (22)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro
3. Pathophysiology of endothelin in the cardiovascular system
4. Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload
5. Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure: Marked increase in endothelin-1 production in the failing heart
6. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
7. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes
8. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
9. Hyperlipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
10. Stimulation of adipogenesis in fibroblasts by PPAR gamma2, a lipid-activated transcription factor
11. The mouse peroxisome proliferator-acivated receptor recognizes a response element in the 5′-flanking sequence of the rat acyl CoA oxidase gene
12. Peroxisome proliferator-activated receptor a negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1
13. Peroxisome proliferator-activated receptor gene expression in human tissues: Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
14. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
15. Rat myocardial mechanics during pressure-induced hypertrophy development and reversal
16. Long-term endothelin receptor antagonist administration improves alterations in expression of various cardiac genes in failing myocardium in rats with heart failure
17. Expression of cellular oncogenes in the myocardium during the developmental stage and pressure-overload hypertrophy on the rat heart
18. Stimulation of peroxisome proliferator-activated receptor-α (PPARα) decreases cardiac hypertrophy and endothelin-1 expression in rats both in vitro and in vivo
19. Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-α expression in neonatal rat cardiac myocytes
20. Tumor necrosis factor-α and tumor necrosis factor receptors in the failing human heart
21. Cellular basis for the negative inotropic effects of tumor necrosis factor-α in the adult mammalian heart
22. Transcriptional regulation of the endothelin-1 gene by TNF-alpha