Mispaired P3 region in the hierarchical folding pathway of the Tetrahymena ribozyme

Genes to Cells

Volumn 7, Issue 8, 2002, Pages 851-860

  Ohki, Yasushi ^a   Ikawa, Yoshiya ^a   Shiraishi, Hideaki ^a   Inoue, Tan ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME; RNA; MAGNESIUM;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RNA STRUCTURE; STRUCTURE ANALYSIS; TETRAHYMENA; THERMODYNAMICS; ANIMAL; CHEMISTRY; CONFORMATION; ENZYMOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE;

ANIMAL; BASE SEQUENCE; KINETICS; MAGNESIUM; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDE PROBES; PROTEIN FOLDING; RNA, CATALYTIC; SUPPORT, NON-U.S. GOV'T; TETRAHYMENA; ANIMALS;

TETRAHYMENA;

EID: 0036668472     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00567.x     Document Type: Article

References (34)

1. Representation of the secondary and tertiary structure of group I introns
2. Characterization of the Tetrahymena ribozyme folding pathway using the kinetic footprinting reagent peroxynitrous acid
3. Self-splicing of the Tetrahymena pre-rRNA is decreased by misfolding during transcription
4. Fingerprinting the folding of a group I precursor RNA
5. A preorganized active site in the crystal structure of the Tetrahymena ribozyme
6. A simple and rapid method for generating a deletion by PCR
7. The structure of Group I ribozymes
8. Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns
9. Modelling of the three-dimensional architecture of Group I catalytic introns based on comparative sequence analysis
10. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates
11. A deteriorated triple-helical scaffold accelerates formation of the Tetrahymena ribozyme active structure
12. Fast folding of a ribozyme by stablizing core interactions: Evidence for multiple folding pathways in RNA
13. Folding of RNA involves parallel pathways
14. Magnesium-dependent folding of self-splicing RNA: Exploring the link between cooperativity, thermodynamics, and kinetics
15. Folding intermediates of a self-splicing RNA: Mispairing of the catalytic core
16. Fast folding mutants of the Tetrahymena group I ribozyme reveal a rugged folding energy landscape
17. 2+ concentration for kinetic folding of the tetrahymena ribozyme
18. New pathways in folding of the Tetrahymena group I RNA enzyme
19. Probing the folding landscape of the Tetrahymena ribozyme: Commitment to form the native conformation is late in the folding pathway
20. Small angle X-ray scattering reveals a compact intermediate in RNA folding
21. RNA folding at millisecond intervals by synchrotron hydroxyl radical footprinting
22. Time-resolved synchrotron X-ray 'Footprinting', a new approach to the study of nucleic acid structure and function
23. Mutagenesis and comparative sequence analysis of a base triple joining the two domans of group I ribozymes
24. Joining the two domains of a group I ribozyme to form the catalytic core
25. Kinetic intermediates trapped by native interactions in RNA folding
26. Exposing the kinetic traps in RNA folding
27. Kinetic oligonucleotide hybridization for monitoring kinetic folding of large RNAs
28. Byond kinetic traps in RNA folding
29. Concerted kinetic folding of a multidomain ribozyme with a disrupted loop-receptor interaction
30. Compensatory mutations demonstrate that P8 and P6 are RNA secondary structure elements important for processing of a group I intron
31. Kinetic intermediates in RNA folding
32. The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding
33. The P9.1-P9.2 peripheral extension helps guide folding of the Tetrahymena ribozyme
34. A single-molecule study of RNA catalysis and folding