Induction of an unregulated channel by mutations in adenine nucleotide translocase suggests an explanation for human ophthalmoplegia

Human Molecular Genetics

Volumn 11, Issue 16, 2002, Pages 1835-1843

  Chen, Xin Jie ^a,b  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; PET9 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL GROWTH; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EXTERNAL OPHTHALMOPLEGIA; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; MEMBRANE TRANSPORT; MISSENSE MUTATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; ALLELE; CELL MEMBRANE POTENTIAL; CHRONIC PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; DOMINANT GENE; ENZYMOLOGY; FUNGAL GENE; GENETICS; METABOLISM; MITOCHONDRION;

FORMICIDAE; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

ADENINE NUCLEOTIDE TRANSLOCATOR 1; ALLELES; DNA, MITOCHONDRIAL; GENES, DOMINANT; GENES, FUNGAL; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MITOCHONDRIAL SWELLING; MUTATION, MISSENSE; OPHTHALMOPLEGIA, CHRONIC PROGRESSIVE EXTERNAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0036667983     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.16.1835     Document Type: Article

References (41)

1. Molecular aspects of the adenine nucleotide carrier from mitochondria
2. Highly conserved charge-pair networks in the mitochondrial carrier family
3. The mitochondrial ADP/ATP carrier: Structural, physiological and pathological aspects
4. Identification and functions of new transporters in yeast mitochondria
5. Molecular weight and hydrodynamic parameters of the adenosine 5′-diphosphate-adenosine 5′-triphosphate carrier in Triton X-100
6. 2+-induced membrane transition in mitochondria. I. The protective mechanisms
7. 2+ trigger site
8. Recent progress on regulation of the mitochondrial permeability transition pore: A cyclosporin-sensitive pore in the inner mitochondrial membrane
9. The mitochondrial permeability transition
10. 2+-dependent pore of possible relevance to re-perfusion-induced injury. Evidence that ADP facilitates pore interconversion between the closed and open states
11. Mitochondrial calcium transport: Physiological and pathological relevance
12. The mitochondrion in apoptosis: How Pandora's box opens
13. 2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and interacting with the adenine nucleotide translocase
14. 2+
15. Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore
16. Mitochondrial transport of cations: Channels, exchangers, and permeability transition
17. Role of adenine nucleotide translocator 1 in mtDNA maintenance
18. Structure-function studies of adenine nucleotide transport in mitochondria. I. Construction and genetic analysis of yeast mutants encoding the ADP/ATP carrier protein of mitochondria
19. Structure-function studies of adenine nucleotide transport in mitochondria. II. Biochemical analysis of distinct AAC1 and AAC2 proteins in yeast
20. The petite mutation in yeasts: 50 years on
21. Mcx1p, a ClpX homologue in mitochondria of Saccharomyces cerevisiae
22. Topogenesis of cytochrome oxidase subunit II. Mechanisms of protein export from the mitochondrial matrix
23. Multiple conductance channel activity of wild-type and voltage-dependent anion-selective channel (VDAC)-less yeast mitochondria
24. Activity of the mitochondrial multiple conductance channel is independent of the adenine nucleotide translocator
25. An electrophysiological study of yeast mitochondria. Evidence for two inner membrane anion channels sensitive to ATP
26. Properties of a cyclosporin-insensitive permeability transition pore in yeast mitochondria
27. Characterization of the yeast mitochondria unselective channel: A counter-part to the mammalian permeability transition pore?
28. + transport by free fatty acids, which is further stimulated by mersalyl
29. Photomodification of mitochondrial proteins by azido fatty acids and its effect on mitochondrial energetics. Further evidence for the role of the ADP/ATP carrier in fatty-acid-mediated uncoupling
30. Uncoupling: New approaches to an old problem of bioenergetics
31. Fatty acids induced uncoupling of Saccharomyces cerevisiae mitochondria requires an intact ADP/ATP carrier
32. Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential
33. Probing the role of positive residues in the ADP/ATP carrier from yeast. The effect of six arginine mutations of oxidative phosphorylation and AAC expression
34. Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein R and Bcl-2
35. Adenine nucleotide translocase-1, a component of the permeability transition pore, can dominantly induce apoptosis
36. Bax and adenine nucleotide translocase cooperate in the mitochondrial control of apoptosis
37. Protein translocation pathways of the mitochondria
38. Low- and high-copy-number shuttle vectors for replication in the budding yeast Kluyveromyces lactis
39. A yeast cyclophilin gene essential for lactate metabolism at high temperature
40. A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein
41. Activity of the Kluyveromyces lactis Pdr5 multidrug transporter is modulated by the Sit4 protein phosphatase