Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways

European Journal of Cell Biology

Volumn 79, Issue 11, 2000, Pages 824-833

  Meinhardt, Gerold ^a   Roth, Jeannette ^a   Totok, Gabriela ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Apoptosis; Phorbol ester; PKC

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADAPTOR PROTEIN; ANTINEOPLASTIC AGENT; BRYOSTATIN 1; CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; COLECALCIFEROL; CYTOCHROME C; DNA; FAS ANTIGEN; FAS LIGAND; GENISTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; RETINOIC ACID; STAUROSPORINE; TETRAPEPTIDE; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; BIOCHEMISTRY; CELL ADHESION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CELL DIFFERENTIATION; CELL STRAIN U937; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0033646717     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00100     Document Type: Article

References (50)

1. Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors
2. Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells
3. Regulation of cell death protease caspase-9 by phosphorylation
4. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
5. mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response
6. Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL
7. Proteases to die for
8. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
9. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
10. 2+ ions
11. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells
12. 1 arrest
13. Inactivation of Bcl-2 by phosphorylation
14. Retrodifferentiation and cell death
15. TPA-induced differentiation and adhesion of U937 cells: Changes in ultrastructure, cytoskeletal organization and expression of cell surface antigens
16. Differentiation and retrodifferentiation of U937 cells: Reversible induction and suppression of intermediate filament protein synthesis
17. Differentiation and retrodifferentiation of human myeloid leukemia cells is associated with reversible induction of cell cycle-regulatory genes
18. Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase
19. Characterization of human TUR leukemia cells: Continued cell cycle progression in the presence of phorbol ester is associated with resistance to apoptosis
20. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
21. Protcolytic activities that mediate apoptosis
22. Protein kinase C delta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
23. Cytochrome e and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
24. Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptor
25. Rescue from programmed cell death in leukemia and normal myeloid cells
26. Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system
27. Differential expression of c-myc, max and mxil in human myeloid leukemia cells during retrodifferentiation and cell death
28. Phorbol ester induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase c-betaII, -epsilon, -zeta and -eta
29. The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis
30. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells
31. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
32. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
33. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
34. Enforced expression of Bcl-XS induces differentiation and sensitizes chronic myelogenous leukemia-blast crisis K562 cells to 1-beta-D-arabinofuranosylcytosine-mediated differentiation and apoptosis
35. Protein kinase C delta is esssential for etoposide-induced apoptosis in salivary gland acinar cells
36. A functional role for mitochondrial protein kinase C alpha in Bcl2 phosphorylation and suppression of apoptosis
37. Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation
38. The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage
39. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
40. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells
41. Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocytic lineage cells
42. Special topic: Apoptosis
43. Expression of the antiapoptotic MCL1 gene product is regulated by a mitogen activated protein kinase-mediated pathway triggered through microtubule disruption and protein kinase C
44. Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation
45. Human erythropoietin receptor increases GATA-2 and Bcl-xL by a protein kinase C-dependent pathway in human erythropoietin-dependent cell line AS-E2
46. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
47. Bcl-2 targets the protein kinase Raf-1 to mitochondria
48. Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies
49. Molecular thanatopsis: A discourse on the Bcl2 family and cell death
50. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)