Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: Zinc increases inhibitory potency

Biological Chemistry

Volumn 383, Issue 7-8, 2002, Pages 1193-1198

  Krauser, Joel A ^a   Potempa, Jan ^a   Travis, James ^a   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Benzamidine; Cysteine protease; Gingipain; Inhibitor; Periodontal disease

Indexed keywords

ARGININE GINGIPAIN; BENZAMIDE DERIVATIVE; BENZAMIDINE DERIVATIVE; CYSTEINE; CYSTEINE PROTEINASE; ENZYME INHIBITOR; HISTIDINE; UNCLASSIFIED DRUG; UREA; ZINC; ADHESIN; ARGINGIPAIN, PORPHYROMONAS GINGIVALIS; CROSS LINKING REAGENT; HEMAGGLUTININ; PROTEINASE INHIBITOR;

ARTICLE; ASSAY; CONTROLLED STUDY; DRUG POTENCY; GINGIVITIS; PATHOGENESIS; PERIODONTAL DISEASE; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DRUG EFFECT; KINETICS; METABOLISM; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

ADHESINS, BACTERIAL; BENZAMIDINES; BINDING SITES; CROSS-LINKING REAGENTS; CYSTEINE ENDOPEPTIDASES; HEMAGGLUTININS; KINETICS; PROTEASE INHIBITORS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; ZINC;

EID: 0036660695     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.131     Document Type: Article

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