Absence of the CD1 molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in mice

Journal of Immunology

Volumn 169, Issue 1, 2002, Pages 151-158

  Sfondrini, Lucia ^a   Besusso, Dario ^a   Zoia, Maria Teresa ^a   Rodolfo, Monica ^a   Invernizzi, Anna Maria ^a   Taniguchi, Masaru ^a   Nakayama, Toshinori ^a   Colombo, Mario Paolo ^a   Ménard, Sylvie ^a   Balsari, Andrea ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOIMMUNITY; CANCER; CANCER INHIBITION; CPG ISLAND; CYTOKINE PRODUCTION; EVALUATION; LYMPHOCYTE SUBPOPULATION; MELANOMA; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; NUDE MOUSE; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE; TRANSPLANTATION;

EID: 0036644072     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.1.151     Document Type: Article

References (64)

1. CpG motifs in bacterial DNA trigger direct B-cell activation
2. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12
3. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
4. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
5. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
6. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
7. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
8. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
9. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
10. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
11. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
12. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
13. Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice
14. Bacterial CpG DNA activates immune cells to signal infectious danger
15. Antimetastatic effect of CpG DNA mediated by type I IFN
16. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
17. + T cells
18. Mouse CD1-specific NK1 T cells: Development, specificity, and function
19. Natural T cells: Cells that co-express NKRP-1 and TCR
20. + cells: New clues to their origin, specificity, and function
21. + T cells: A new family of T cells
22. CD1d-glycolipid tetramers: A new tool to monitor natural killer T cells in health and disease
23. - T cells in mice and humans
24. - α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCRα chain
25. - T cells
26. - subset
27. - T cells
28. + T cells by CD1-expressing cortical thymocytes
29. + T lymphocytes
30. + T cells in major histocompatibility complex class II-deficient mice
31. Mouse CD1 is mainly expressed on hemopoietic-derived cells
32. Tissue-specific recognition of mouse CD1 molecules
33. Tissue distribution, regulation and intracellular localization of murine CD1 molecules
34. + T cell development and early IL-4 production in CD1-deficient mice
35. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4
36. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells
37. + α-β T cells with intermediate TCR induced in the liver of mice by IL-12
38. KRN7000, a novel immunomodulator, and its antitumor activities
39. Effect of KRN7000 (α-galactosylceramide) on CTL induction
40. Immune suppression and skin cancer development: Regulation by NKT cells
41. Direct thymic involvement in anterior chamber-associated immune deviation: Evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice
42. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway
43. Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12
44. A toll-like receptor recognizes bacterial DNA
45. Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction and IL-12 in vaccination against spontaneous tumor development in proto-neu-transgenic mice
46. Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells
47. Essential requirement of an invariant Vα14 T cell antigen receptor expression in the development of natural killer T cells
48. Rapid death and regeneration of NKT cells in anti-CD3ε- or IL-12-treated mice: A major role for bone marrow in NKT cell homeostasis
49. Immunotherapy with CpG motifs from bacterial DNA
50. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
51. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
52. APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells
53. Use of CpG DNA for enhancing specific immune responses
54. Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys
55. NKT cells: Facts, functions and fallacies
56. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells
57. The murine nonclassical class I major histocompatibility complex-like CD1.1 molecule protects target cells from lymphokine-activated killer cell cytolysis
58. + T cell compartments
59. Induction of an antigen-specific, CD1-restricted cytotoxic T lymphocyte response in vivo
60. Diverse TCRs recognize murine CD1
61. CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells
62. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
63. The role of different subsets of T regulatory cells in controlling autoimmunity
64. Regulatory T cells: Key controllers of immunologic selftolerance