Insulin sensitivity and β-cell function in women with polycystic ovary syndrome

Diabetes Care

Volumn 25, Issue 7, 2002, Pages 1217-1222

  Vrbíková, Jana ^a   Bendlová, Bela ^a   Hill, Martin ^a   Vanková, Markéta ^a   Vondra, Karel ^a   Stárka, Luboslav ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANALYSIS OF VARIANCE; ANTHROPOMETRY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; FEMALE; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PANCREAS ISLET BETA CELL; RANK SUM TEST; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; AREA UNDER THE CURVE; BIOLOGICAL MODEL; BLOOD; BODY MASS; BODY WEIGHT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; METABOLISM; PANCREAS ISLET; PATHOPHYSIOLOGY; SECRETION;

INSULIN;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; BODY MASS INDEX; BODY WEIGHT; FEMALE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INSULIN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; OBESITY; POLYCYSTIC OVARY SYNDROME;

EID: 0036637059     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.25.7.1217     Document Type: Article

References (40)

1. Legro RS, Kunselman AR, Dodson WC, Dunaif A: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women [see comments]. J Clin Endocrinol Metab 84:165-169, 1999
2. Dunaif A: Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18:774-800, 1997
3. Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T: Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257-1266, 1992
4. Gennarelli G, Holte J, Berglund L, Berne C, Massobrio M, Lithell H: Prediction models for insulin resistance in the polycystic ovary syndrome. Hum Reprod 15: 2098-2102, 2000
5. Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Tapanainen JS: Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome. Hum Reprod 15: 1266-1274, 2000
6. Dunaif A, Segal KR, Futterweit W, Dobrjansky A: Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38: 1165-1174, 1989
7. Ovesen P, Moller J, Ingerslev HJ, Jorgensen JO, Mengel A, Schmitz O, Alberti KG, Moller N: Normal basal and insulin-stimulated fuel metabolism in lean women with the polycystic ovary syndrome. J Clin Endocrinol Metab 77:1636-1640, 1993
8. Holte J: Polycystic ovary syndrome and insulin resistance: thrifty genes struggling with over-feeding and sedentary life style? J Endocrinol Invest 21:589-601, 1998
9. O'Meara NM, Blackman JD, Ehrmann DA, Barnes RB, Jaspan JB, Rosenfield RL, Polonsky KS: Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab 76:1241-1247, 1993
10. Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS: Insulin secretory defects in polycystic ovary syndrome: relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 96:520-527, 1995
11. Ehrmann DA: Glucose intolerance in the polycystic ovary syndrome: role of the pancreatic beta-cell. J Pediatr Endocrinol Metab 13:1299-1301, 2000
12. Holte J, Bergh T, Berne C, Wide L, Lithell H: Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 80:2586-2593, 1995
13. Holte J, Bergh T, Berne C, Berglund L, Lithell H: Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J Clin Endocrinol Metab 78:1052-1058, 1994
14. Young RP, Critchley JA, Anderson PJ, Lau MS, Lee KK, Chan JC: The short insulin tolerance test: feasibility study using venous sampling. Diabet Med 13:429-433, 1996
15. Vrbikova J, Hill M, Starka L, Cibula D, Bendlova B, Vondra K, Sulcova J, Snajderova M: The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome. Eur J Endocrinol 144: 619-628, 2001
16. Cederholm J, Wibell L: Insulin release and peripheral sensitivity at the oral glucose tolerance test. Diabetes Res Clin Pract 10:167-175, 1990
17. Drivsholm T, Hansen T, Urhammer SA, Palacios RT, Volund A, Borch-Johnsen K, Pedersen OB: Assessment of insulin insensitivity and beta cell function from an oral glucose tolerance test (Abstract). Diabetologia 42 (Suppl. 1):185, 1999
18. Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J: A simple measure of insulin resistance. Lancet 346:120-121, 1995
19. Matsuda M, DeFronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp [see comments]. Diabetes Care 22:1462-1470, 1999
20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
21. Legro RS, Finegood D, Dunaif A: A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome [see comments]. J Clin Endocrinol Metab 83:2694-2698, 1998
22. Rosolova H, Mayer O Jr, Simon J, Sefma F: Detection of risk of insulin resistance in the population. Cas Lek Cesk 137:80-83, 1998
23. Seltzer HS, Allen EW, Herron AL Jr, Brennan MT: Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest 46: 323-335, 1967
24. Ehrmann DA: Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus. Baillieres Clin Obstet Gynaecol 11:335-347, 1997
25. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J: Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22:141-146, 1999
26. Legro RS: Diabetes prevalence and risk factors in polycystic ovary syndrome. Obstet Gynecol Clin North Am 28:99-109, 2001
27. Bergman RN: Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein? Diabetologia 43:946-952, 2000
28. Bergman RN, Ader M: Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11:351-356, 2000
29. Boden G, Chen X, Iqbal N: Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and non-diabetic subjects. Diabetes 47:1609-1612, 1998
30. Ek I, Arner P, Ryden M, Holm C, Thorne A, Hoffstedt J, Wahrenberg H: A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance. Diabetes 51:484-492, 2002
31. Buffington CK, Kitabchi AE: Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. Metabolism 43:1367-1372, 1994
32. Tropeano G, Lucisano A, Liberale I, Barini A, Vuolo IP, Martino G, Menini E, Dell'Acqua S: Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 78:305-309, 1994
33. Peiris AN, Aiman EJ, Drucker WD, Kissebah AH: The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women. J Clin Endocrinol Metab 68:715-720, 1989
34. Ferrannini E: Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 19:477-490, 1998
35. Albareda M, Rodriguez-Espinosa J, Murugo M, de Leiva A, Corcoy R: Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 43:1507-1511, 2000
36. Lillioja S, Nyomba BL, Saad MF, Ferraro R, Castillo C, Bennett PH, Bogardus C: Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J Clin Endocrinol Metab 73:866-876, 1991
37. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, Corgnati A, Muggeo M: Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 68:374-378, 1989
38. Chiu KC, Chuang LM, Yoon C: Comparison of measured and estimated indices of insulin sensitivity and beta cell function: impact of ethnicity on insulin sensitivity and beta cell function in glucose-tolerant and normotensive subjects. J Clin Endocrinol Metab 86:1620-1625, 2001
39. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
40. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D Jr: Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993