Polycystic ovary syndrome and insulin resistance: Thrifty genes struggling with over-feeding and sedentary life style?

Journal of Endocrinological Investigation

Volumn 21, Issue 9, 1998, Pages 589-601

  Holte, J ^a,b  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b Carl von Linne Clinic   (Sweden)

Author keywords

Abdominal fat; Androgens; Body fat distribution; Genes; Insulin resistance; Insulin secretion; Nutrition; Polycystic ovary syndrome

Indexed keywords

ANDROGEN; CORTICOSTEROID; FATTY ACID; INSULIN; INSULIN RECEPTOR; SEX HORMONE BINDING GLOBULIN; STEROID 17,20 LYASE; TESTOSTERONE;

ABDOMEN; ADIPOSE TISSUE; ADRENAL GLAND; ANDROGEN BLOOD LEVEL; ANDROGEN SYNTHESIS; ARTICLE; ENERGY CONSERVATION; ENZYME ACTIVITY; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE; MUSCLE; MUSCLE STRENGTH; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PANCREAS ISLET BETA CELL; SIGNAL TRANSDUCTION; SITTING; STEROIDOGENESIS;

EID: 0031752390     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03350784     Document Type: Article

References (101)

1. Holte J. Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome. Baillieres Clin. Endocrinol. Metab. 10: 221, 1996.
2. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanisms and implications for pathogenesis. Endocr. Rev. 18: 774, 1997.
3. Dunaif A., Segal K.R., Futterweit W., Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 38: 1165, 1989.
4. Ovesen P., Moller J., Ingerslev H.J., Jorgensen J.O.L., Mengel A., Schmitz O., Alberti K.G.M.M., Moller N. Normal basal and insulin-stimulated fuel metabolism in lean women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 77: 1636, 1993.
5. Holte J., Bergh T., Berne C., Berglund L., Lithell H. Enhanced insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J. Clin. Endocrinol. Metab. 78: 1052, 1994.
6. Gennarelli G. Polycystic ovary syndrome. A study on factors of potential impact on body fat and carbohydrate meatbolism [Doctoral dissertation]. Uppsala University, 1998.
7. O'Meara N.M., Blackman J.D., Ehrman D.A., Barnes R.B., Jaspan J.B., Rosenfield R.L, Polonsky K.S. Defects in beta-cell function in functional ovarian hyperandrogenism. J. Clin. Endocrinol. Metab. 76: 1241, 1993.
8. Holte J., Bergh T., Berne C., Wide L., Lithell H. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 80: 2586, 1995.
9. Ehrmann D.A., Sturis J., Byrne M.M., Karrison T., Rosenfield R.L., Polonsky K.S. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J. Clin. Invest. 96: 520, 1995.
10. Evans D.J., Hoffman R.G., Kalkhoff R.K., Kissebah A.H. Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women. Metabolism. 33: 68, 1984.
11. Kissebah A.H., Peiris A.N. Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 5: 83, 1989.
12. Björntorp P. Abdominal obesity and the development of noninsulin-dependent diabetes mellitus. Diabetes Metab. Rev. 4: 615, 1988.
13. Rebuffe-Scrive M., Cullberg G., Lundberg P.A., Lindstedt G., Björntorp P. Anthropometric variables and metabolism in polycystic ovarian disease. Horm. Metab. Res. 21: 391, 1989.
14. Bringer J., Lefebvre P., Boulet F., Grigorescu F., Renard E., Hedon B., Orsetti A., Jaffiol C. Body composition and regional fat distribution in polycystic ovarian syndrome. Relationship to hormonal and metabolic profiles. Ann. N. Y. Acad. Sci. 687: 115, 1993.
15. Conway G.S., Jacobs H.S., Holly J.M., Wass J.A. Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome. Clin. Endocrinol. 33: 593, 1990.
16. Dunaif A., Graf M., Mandeli J., Laumas V., Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J. Clin. Endocrinol. Metab. 65: 499, 1987.
17. Robinson S., Kiddy D., Gelding S.V., Willis D., Niththyananthan R., Bush A., Johnston D.G., Franks S. The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin. Endocrinol. 39: 351, 1993.
18. Dahlgren E., Janson P.O., Johansson S., Lapidus L., Oden A. Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women. Acta Obstet. Gynecol. Scand. 71: 599, 1992.
19. Jacobs H.S. Polycystic ovary syndrome: the present position. Gynecol. Endocrinol. 10: 427, 1996.
20. Moller D.E., Flier J.S. Insulin resistance-mechanisms, syndromes, and implications. N. Engl. J. Med. 325: 938, 1991.
21. Poretsky L. On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr. Rev. 12: 3, 1991.
22. DeFronzo R.A., Tobin J.D., Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237: E214, 1979.
23. Bonora E., Moghetti P., Zancanaro C., Cigolini M., Querena M., Cacciatori V., Corgnati A., Muggeo M. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J. Clin. Endocrinol. Metab. 68: 374, 1989.
24. Bergman R.N., Finegood D.T., Ader M. Assessment of insulin sensitivity in vivo. Endocr. Rev. 6: 45, 1985.
25. Dale P.O., Tanbo T., Vaaler S., Abyholm T. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations. Fertil. Steril. 58: 487, 1992.
26. Morales A.J., Laughlin G.A., Butzow T., Maheshwari H., Baumann G., Yen S.S.C. Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. J. Clin. Endocrinol. Metab. 81: 2854, 1996.
27. Dunaif A., Sorbara L., Delson R., Green G. Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean-Hispanic women. Diabetes. 42: 1462, 1993.
28. Holte J. Insulin secretion and sensitivity in polycystic ovary syndrome-role of body fat distribution. In: Filicori M., Flamigni C., (Ed.) The ovary: regulation, dysfunction and treatment. Elsevier Science B.V., New York, 1996, p. 237.
29. Lanzone A., Caruso A., Di Simone N., De Carolis S., Fulghesu A.M., Mancuso S. Polycystic ovary disease. A risk factor for gestational diabetes? J. Reprod. Med. 40: 312, 1995.
30. Wortsman J., de Angeles S., Futterweit W., Singh K.B., Kaufmann R.C. Gestational diabetes and neonatal macrosomia in the polycystic ovary syndrome. J. Reprod. Med. 36: 659, 1991.
31. Holte J., Gennarelli G., Wide L., Lithell H., Berne C. High prevalence of polycystic ovaries and associated clinical, endocrine and metabolic features in women with previous gestational diabetes mellitus. J. Clin. Endocrinol. Metab. 83: 1143, 1998.
32. Holte J., Gennarelli G., Berne C., Bergh T., Lithell H. Elevated ambulatory day-time blood pressure in women with polycystic ovary syndrome: a sign of a pre-hypertensive state? Hum. Reprod. 11: 23, 1996.
33. Dahlgren E., Johansson S., Lindstedt G., Knutsson F., Oden A., Janson P.O., Mattson L.A., Crona N., Lundberg P.A. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil. Steril. 57: 505, 1992.
34. Conway G.S., Agrawal R., Betteridge D.J., Jacobs H.S. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin. Endocrinol. 37: 119, 1992.
35. Holte J., Bergh T., Berne C., Lithell H. Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables. Clin. Endocrinol. 41: 463, 1994.
36. Randle P.J., Hales C.N., Garland P.B., Newsholme E.A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1: 785, 1963.
37. Lakatta E. Similar myocardial effects of aging and hypertension. Eur. Heart J. 11 (Suppl. G): 29, 1990.
38. Lemne C., Lindvall K., Georgiades A., Fredriksson M., deFaire U. Structural cardiac changes in relation to 24-h ambulatory blood pressure in borderline hypertension. J. Intern. Med. 238: 49, 1995.
39. Singer P., Godicke W., Voigt S., Hajdu I., Weiss M. Postprandial hyperinsulinemia in patients with mild essential hypertension. Hypertension 7: 182, 1985.
40. Jern S. Effects of acute carbohydrate administration on central and peripheral hemodynamic responses to mental stress. Hypertension 18: 790, 1991.
41. Ferrannini E., Barrett E.J., Bevilacqua S., DeFronzo R.A. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72: 1737, 1983.
42. Reaven G.M., Chen Y.D. Role of abnormal free fatty acid metabolism in the development of non-insulin-dependent diabetes mellitus. Am. J. Med. 85: 106, 1988.
43. Martin M.L, Jensen M.D. Effects of body fat distribution on regional lipolysis in obesity. J. Clin. Invest. 88: 609, 1991.
44. Björntorp P. Abdominal obesity and risk. Clin. Exp. Hypertens. [a] 12: 783, 1990.
45. Andersson P.-E. Aspects of insulin resistance with special reference to the vasoactive effects of insulin. [Doctoral dissertation]. Uppsala University, 1998.
46. Bouchard C., Tremblay A., Despres J.P., Nadeau A., Lupien P.J., Theriaulet G., Dussault J., Moorjani S., Pinault S., Fournier G. The response to long-term overfeeding in identical twins. N. Engl. J. Med. 322: 1477, 1990.
47. Rebuffe-Scrive M., Brönnegard M., Nilsson A., Eldh J., Gustafsson J.A., Björntorp P. Steroid hormone receptors in human adipose tissues. J. Clin. Endocrinol. Metab. 71: 1215, 1990.
48. Björntorp P. Hormonal regulation of fat distribution. In: Basdevant A., Bringer J., Lefebvre, (Ed.) Weight, nutrition and hormonal events in women. Oxford University Press, Oxford, 1997, p. 21. (Edwards R.G., Beard H.K., Bradshaw J.P., ed. Human Reproduction; vol 12; suppl 1).
49. Rebuffé-Scrive M., Mårin P., Björntorp P. Effect of testoterone on abdominal tissue in men. Int. J. Obesity. 15: 791, 1991.
50. Mårin P., Holmäng S., Gustafsson C., Björntorp P. Androgen treatment of abdominally obese men. Obesity Res. 1: 245, 1993.
51. Holte J., Bergh T., Gennarelli G., Wide L. The independent effect of polycystic ovary syndrome and obesity on serum concentrations of gonadotrophins and sex steroids in premenopausal women. Clin. Endocrinol. 41: 473, 1994.
52. Ek I., Arner P., Bergqvist A., Carlström K., Wahrenberg H. Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance? J. Clin. Endocrinol. Metab. 82: 1147, 1997.
53. De Pergola G., Holmäng A., Svedberg J., Giorgino R., Björntorp P. Testosterone treatment of ovariectomized rats: effects on lipolysis regulation in adipocytes. Acta Endocrinol. 123: 61, 1990.
54. Rebuffe-Scrive M., Enk L., Crona N., Lönnroth P., Abrahamsson L., Smith U., Björntorp P. Fat cell metabolism in different regions in women. Effect of menstrual cycle, pregnancy, and lactation. J. Clin. Invest. 75: 1973, 1985.
55. Ottosson M., Vikman A.K., Enerback S., Olivecrona G., Björntorp P. The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue. J. Clin. Endocrinol. Metab. 79: 820, 1994.
56. Stewart P.M., Shackleton C.H., Beastall G.H., Edwards C.R. 5 alpha-reductase activity in polycystic ovary syndrome. Lancet 335: 431, 1990.
57. Miller J.E., Bray M.A., Faiman C., Reyes F.I. Characterization of 24-h cortisol release in obese and non-obese hyperandrogenic women. Gynecol. Endocrinol. 8: 247, 1994.
58. Rodin A., Thakkar H., Yaylor N., Clayton R. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11β-hydroxysteroid dehydrogenase. N. Engl. J. Med. 330: 460, 1994.
59. Modell E., Goldstein D., Reyes F.I. Endocrine and behavioural responses to psychological stress in hyperandrogenic women. Fertil. Steril. 53: 454, 1990.
60. Azziz R., Bradley E.L., Potter H.D., Boots L.R. Adrenal androgen excess in women: lack of a role for 17-hydroxylase and 17,20-lyase dysregulation. J. Clin. Endocrinol. Metab. 80: 400, 1995.
61. Meikle A.W., Worley R.J., West CD. Adrenal corticoid hyperresponsiveness in hirsute women. Fertil. Steril. 41: 575, 1984.
62. Lanzone A., Petraglia F., Fulghesu A.M., Ciampelli M., Caruso A., Mancuso S. Corticotropin-releasing hormone induces an exaggerated response of adrenocorticotropic hormone and cortisol in polycystic ovary syndrome. Fertil. Steril. 63: 1195, 1995.
63. Mårin P., Darin N., Amemiya T., Andersson B., Jern S., Björntorp P. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism 41: 882, 1992.
64. Björntorp P. Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease? J. Intern. Med. 230: 195, 1991.
65. Prelevic G.M., Wurzburger M.I., Balint-Peric L., Ginsburg J. Twenty-four-hour serum growth hormone, insulin, C-peptide and blood glucose profiles and serum insulin-like growth factor-I concentrations in women with polycystic ovaries. Norm. Res. 37: 125, 1992.
66. Gennarelli G., Holte J., Stridsberg M., Niklasson F., Berne C., Bäckström T. The counterregulatory response to hypoglycaemia in women with the polycystic ovary syndrome. Clin. Endocrinol. 46: 167, 1997.
67. Conway G.S., Jacobs H.S. Leptin: a hormone of reproduction. Hum. Reprod. 12: 633, 1997.
68. Chapman I.M., Witter G.A., Norman R.J. Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin. Endocrinol. 46: 175, 1997.
69. Gennarelli G., Holte J., Wide L, Berne C., Lithell H. Is there a role for leptin in the endocrine and metabolic aberrations of polycystic ovary syndrome. Hum. Reprod. 13: 535, 1998.
70. Dunaif A., Segal K.R., Shelley D.R., Green G., Dobrjansky A., Licholai T. Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41: 1257, 1992.
71. Kahn B.B., Flier J.S. The syndromes of insulin resistance and acanthosis nigricans: insulin-receptor disorders in man. N. Engl. J. Med. 294: 739, 1976.
72. Dunaif A., Xia J., Book C.-B., Schenker E., Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J. Clin. Invest. 96: 801, 1995.
73. Zhang L-H., Rodriguez H., Ohno S., Miller W.L. Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc. Natl. Acad Sci. USA 92: 10619, 1995.
74. Conway G.S., Avey C., Rumsby G. The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome. Hum. Reprod. 9: 1681, 1994.
75. Dunaif A., Finegood D. B-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 81: 942, 1996.
76. Ciampelli M., Fulghesu A.M., Cucinelli F., Pavone V., Caruso A., Mancuso S., Lanzone A. Heterogeneity in beta-cell activity, hepatic insulin clearance and peripheral insulin sensitivity in women with polycystic ovary syndrome. Hum. Reprod. 12: 1897, 1997.
77. Peiris A.N., Mueller R.A., Struve M.F., Smith G.A., Kissebah A.H. Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women. J. Clin. Endocrinol. Metab. 64: 162, 1987.
78. Van G.L, Vansant G., Van A.K., De L.I. Decreased hepatic insulin extraction in upper body obesity: relationship to unbound androgens and sex hormone binding globulin. Diabetes Res. Clin. Pract. 12: 99, 1991.
79. Kahn S.E., Prigeon R.L., McCulloch D.K., Boyko E.J., Bergman R.N., Schwartz M.W., Neifing J.L., Ward W.K., Beard J.C., Palmer J.P., Porte D. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42: 1663, 1993.
80. Clausen J., Borch-Johnsen K., Ibsen H., Bergman R., Hougaard P., Winther K., Pedersen O. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy caucasians. J. Clin. Invest. 98: 1195, 1996.
81. Cohen J.C., Hickman R. Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids. J. Clin. Endocrinol. Metab. 64: 960, 1987.
82. Landon J., Wynn V., Houghton B.J., Cooke J.N.C. Effects of anabolic steroid, methandienone, on carbohydrate metabolism in man. II. Effect of methandienone on response to glucagon, adrenalin, and insulin in the fasted subject. Metabolism. 11: 513, 1962.
83. Waterworth D.M., Bennett S.T., Gharani N., et al. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 349: 986, 1997.
84. Franks S., Gharani N., Waterworth D., Batty S., White D., Williamson R., McCarthy M. The genetic basis of polycystic ovary syndrome. Hum. Reprod. 12: 2641, 1997.
85. Lillioja S., Nyomba B.L., Saad M.F., Ferraro R., Castillo C., Bennett P.H., Bogardus C. Exaggerated early insulin release and insulin resistance in a diabetes-prone population: a metabolic comparison of Pima Indians and Caucasians. J. Clin. Endocrinol. Metab. 73: 866, 1991.
86. Le Stunff C., Bougnères P. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes 43: 696, 1994.
87. Fletcher J.M., McNurlan M.A., McHardy K.C. Residual abnormalities of insulin secretion and sensitivity after weight loss by obese women. Eur. J. Clin. Nutr. 43: 539, 1989.
88. Le Marchand Y., Freychet P., Jeanrenaud B. Longitudinal study on the establishment of insulin resistance in hypothalamic obese mice. Endocrinology 102: 74, 1985.
89. Golland I.M., Vaughan W.C., Shalet S.M., Million L.H., Elstein M. Lack of predictive value of HbA1 for impaired glucose tolerance in polycystic ovary syndrome. Gynecol. Endocrinol. 3: 229, 1989.
90. McCluskey S., Evans C., Lacey J.H., Pearce J.M., Jacobs H. Polycystic ovary syndrome and bulimia. Fertil. Steril. 55: 287, 1991.
91. Jahanfar S., Eden J.A., Nguyent T.V. Bulimia nervosa and polycystic ovary syndrome. Gynecol. Endocrinol. 9: 113, 1995.
92. Raphael F.J., Rodin D.A., Peattie A., Bano G., Kent A., Nussey S.S., Lacey J.H. Ovarian morphology and insulin sensitivity in women with bulimia nervosa. Clin. Endocrinol. 43: 451, 1995.
93. Blouin A.G., Blouin J.H., Braaten J.T., Sarwar G., Bushnik T., Walker J. Physiological and psychological response to a glucose challenge in bulimia. Int. J. Eating Disord. 10: 285, 1991.
94. Givens J.R., Kurtz B.R., Kitabchi A.E., Bittle J.B., Karas J.G., Mitchell J.A., Howes J.F. Reduction of hyperinsulinemia and insulin resistance by opiate receptor blockade in the polycystic ovary syndrome with acanthosis nigricans. J. Clin. Endocrinol. Metab. 64: 377, 1987.
95. Lanzone A., Fulghesu A.M., Guido M., Ciampelli M., Caruso A., Mancuso S. Differential androgen response to adrenocorticotrophin hormone stimulation and effect of opioid antagonist on insulin secretion in polycystic ovarian syndrome. Hum. Reprod. 9: 2242, 1994.
96. Fulghesu A.M., Lanzone A., Cucinelli F., Caruso A., Mancuso S. Long-term naltrexone treatment reduces the exaggerated insulin secretion in patients with polycystic ovary disease. Obstet. Gynecol. 82: 191, 1993.
97. Björntorp P. Hyperandrogenicity in women-a prediabetic condition? J. Intern. Med. 234: 579, 1993.
98. Giudice L.C. The insulin-like growth factor system in normal and abnormal human ovarian follicle development. Am. J. Med. 98: 1995.
99. Moghetti P., Tosi F., Castello R., Magnani C., Negri C., Furlani L., Caputo M., Muggeo M. The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment; evidence that androgens impair insulin action in women. J. Clin. Endocrinol. Metab. 81: 952, 1996.
100. Robinson S., Chan S.P., Spacey S., Anyaoku V., Johnston D.G., Franks S. Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clin. Endocrinol. 36: 537, 1992.
101. Poison D.W., Adams J., Wadsworth J., Franks S. Polycystic ovaries-a common finding in normal women. Lancet 1: 870, 1988