Synthesis and structure-activity relationships of 4-amino-5-chloro-N-(1,4- dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide derivatives, novel and potent serotonin 5-HT3 and dopamine D2 receptors dual antagonist

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 7, 2002, Pages 941-959

  Hirokawa, Yoshimi ^a   Harada, Hiroshi ^a   Yoshikawa, Takashi ^a   Yoshida, Naoyuki ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

4 amino 5 chloro 2 methoxybenzamide; Antiemetic; Dopamine D2 receptor; Hexahydro 1,4 diazepine; Optical resolution; Serotonin 5 HT3 receptor

Indexed keywords

ANTIEMETIC AGENT; BENZAMIDE DERIVATIVE; DOMPERIDONE; DOPAMINE RECEPTOR BLOCKING AGENT; METOCLOPRAMIDE; ONDANSETRON; APOMORPHINE; DOPAMINE 2 RECEPTOR; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; EMETIC AGENT; SEROTONIN 3 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ANTIEMETIC ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CHEMICAL MODIFICATION; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; NONHUMAN; OPTICAL DENSITY; RAT; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; STRUCTURE ACTIVITY RELATION; ANIMAL; BRAIN; DOG; DRUG ANTAGONISM; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METABOLISM; PHYSICAL CHEMISTRY; SYNTHESIS;

ANIMALS; ANTIEMETICS; APOMORPHINE; BENZAMIDES; BRAIN; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DOPAMINE ANTAGONISTS; EMETICS; INDICATORS AND REAGENTS; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036634910     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.941     Document Type: Article

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