Identification of extrinsic blood coagulation pathway inhibitors from the tick Ornithodoros savignyi (Acari: Argasidae)

Experimental Parasitology

Volumn 101, Issue 2-3, 2002, Pages 138-148

  Ehebauer, M T ^a   Mans, B J ^a   Gaspar, A R M ^a   Neitz, A W H ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; CALCIUM ION; PROTEIN; PROTEIN BSAP1; PROTEIN BSAP2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CELL MEMBRANE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; SEPARATION TECHNIQUE; TICK;

ADSORPTION; AMINO ACIDS; ANIMALS; ANTICOAGULANTS; BARIUM SULFATE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HUMANS; LIPOSOMES; MOLECULAR WEIGHT; ORNITHODOROS; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; SALIVARY GLANDS; SALIVARY PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ACARI; ARACHNIDA; ARGASIDAE; HEXAPODA; ORNITHODOROS; ORNITHODOROS SAVIGNYI;

EID: 0036628342     PISSN: 00144894     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4894(02)00102-9     Document Type: Article

References (40)

1. Aguilar M., Hearn M.T.W. High-resolution reversed-phase high-performance liquid chromatography of peptides and proteins. Methods of Enzymology. 270:1996;3-26.
2. Bajaj S.P., Birktoft J.J. Human factor IX and factor IXa. Methods of Enzymology. 222:1993;96-128.
3. Bindlingmeyer B.A., Cohen S.A., Tarvin T.L. Rapid analysis of amino acids using pre-column derivatization. Journal of Chromatography. 336:1984;93-104.
4. Brown S.J., Shapiro S.Z., Askenase P.H. Characterization of tick antigens inducing host immune resistance: I. Immunization of guinea pigs with Amblyomma americanum-derived salivary gland extracts and identification of an important salivary gland protein antigen with guinea pig anti-tick antibody. Journal of Immunology. 133:1984;3319-3325.
5. Deacon L.M., Howell R.M. A classification of barium sulphates, used as clotting-factor adsorbents, based on their affinity for anionic dyes. Biochemical Society Transactions. 3:1975;268-270.
6. Dennis M.S., Lazarus R.A. Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent inhibitors selected form libraries by phage display. Journal of Biological Chemistry. 269:1994a;22129-22136.
7. Dennis M.S., Lazarus R.A. Kunitz domain inhibitors of tissue factor-factor VIIa. I. Potent and specific inhibitors by competitive phage selection. Journal of Biological Chemistry. 269:1994b;22137-22144.
8. Dennis M.S., Elgenbrot C., Skelton N.J., Ultsch M.H., Santell L., Dweyer M.A., O'Connell M.P., Lazarus R.A. Peptide exosite inhibitors of factor VIIa as anticoagulants. Nature. 404:2000;465-470.
9. Dupe R.J., Howell R.M., Deacon L.M. The significance of crystal structure and charge of clotting-factor adsorbents. Biochemical Society Transactions. 3:1975;270-272.
10. Flengsrud R. Purification and some characteristics of human coagulation factor VII. European Journal of Biochemistry. 98:1979;455-464.
11. Fujikawa K., Davie W. Bovine factor IX (Christmas factor). Methods of Enzymology. XLV:1976;74-83.
12. Gaspar A.R.M., Crause J.C., Neitz A.W.H. Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi. Experimental and Applied Acarology. 19:1995;117-126.
13. Gaspar A.R.M., Joubert A.M., Crause J.C., Neitz A.W.H. Isolation and characterization of an anticoagulant from the salivary glands of the tick, Ornithodoros savignyi (Acari: Argasidae). Experimental and Applied Acarology. 20:1996;583-598.
14. Gordon R.J., Allen R.J. Factor V and VII anticoagulant activities in the salivary glands of feeding Dermacentor andersoni ticks. Journal of Parasitology. 77:1991;167-170.
15. Jesty J., Nemerson Y. Purification of factor VII from bovine plasma. Journal of Biological Chemistry. 249:1974;509-515.
16. Jie K.G., Gijsbers B.L.M.G., Vermeer C. A specific colorimetric staining method for. γ -carboxyglutamic acid-containing proteins in polyacrylamide gels Analytical Biochemistry. 224:1995;163-165.
17. Joubert A.M., Louw A.I., Joubert F., Neitz A.W.H. Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi. Experimental and Applied Acarology. 22:1998;603-619.
18. Kelley R.F., Costas K.E., O'Connell M., Lazarus R.A. Analysis of the factor VIIa binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry. 34:1995;10383-10392.
19. Kindmark C.L., Williams J.M. Purification of human C-reactive protein by barium sulphate and preparative agarose electrophoresis. APMIS. 97:1989;891-896.
20. Mahlaku, M.M., Gaspar, A.R.M., Neitz, A.W.H., 2001. Characterization of the proteolytic activity in the salivary glands of the tick, Ornithodoros savignyi. International Union of Biochemistry and Molecular Biology, Special Meeting on The Biochemical and Molecular Basis of Disease, Cape Town.
21. Mans B.J., Gaspar A.R.M.D., Louw A.I., Neitz A.W.H. Apyrase activity and platelet aggregation inhibitors of the tick, Ornithodoros savignyi (Acari: Argasidae). Experimental and Applied Acarology. 22:1998a;353-366.
22. Mans B.J., Louw A.I., Gaspar A.R.M.D., Neitz A.W.H. Purification and characterization of apyrase from the tick, Ornithodoros savignyi. Comparative Biochemistry and Physiology B. 120:1998b;617-624.
23. Mans B.J., Coetzee J., Louw A.I., Gaspar A.R.M., Neitz A.W.H. Disaggregation of aggregated platelets by apyrase from the tick, Ornithodoros savignyi (Acari: Argasidae). Experimental and Applied Acarology. 24:2000;271-282.
24. Mans B.J., Louw A.I., Neitz A.W.H. Amino acid sequence and structure modeling of savignin, a thrombin inhibitor from the tick, Ornithodoros savignyi. Insect Biochemistry and Molecular Biology. 32:2002a;821-828.
25. Mans B.J., Louw A.I., Neitz A.W.H. Savignygrin, a platelet aggregation inhibitor from the soft tick, Ornithodoros savignyi, presents the RGD integrin recognition motif on the Kunitz-BPTI fold. Journal of Biological Chemistry. 277:2002b;21371-21378.
26. Mans, B.J., Louw, A.I., Neitz, A.W.H., 2002c. Evolution of hematophagy in ticks: common origins for blood coagulation and platelet aggregation inhibitors from soft ticks of the genus Ornithodoros. Molecular Biology and Evolution 19, (in press).
27. Mans B.J., Steinmann C.M., Venter J.D., Louw A.I., Neitz A.W.H. Pathogenic mechanisms of sand tampan toxicoses induced by the tick, Ornithodoros savignyi. Toxicon. 40:2002;1007-1016.
28. Mathews C.K., Holde K.E. Biochemistry. 1991;The Benjamin/Cummings, Redwood City, CA.
29. 4. Thrombosis and Haemostasis. 46:1981;667.
30. Nienaber J., Gaspar A.R.M.D., Neitz A.W.H. Savignin, a potent thrombin inhibitor isolated from the salivary glands of the tick Ornithodoros savignyi (Acari: Argasidae). Experimental Parasitology. 93:1999;82-91.
31. Obenchain F.D., Galun R. Physiology of Ticks. 1982;Pergamon Press, Oxford.
32. Patrickios C.S., Yamasaki E.N. Polypeptide amino acid composition and isoelectric point. Analytical Biochemistry. 231:1995;82-91.
33. Persson A., Chang D., Rust K., Moxley M., Longmore W., Crouch E. Purification and biochemical characterization of CP4 (SP-D), a collagenous surfactant-associated protein. Biochemistry. 28:1989;6361-6367.
34. 2+ Analytical Biochemistry. 136:1984;119-126.
35. Schägger H., von Jagow G. Tricine-sodium dodecyl sulphate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to100. kDa Analytical Biochemistry. 166:1987;368-379.
36. Shrive A.K., Cheetham G.M.T., Holden D., Myles D.A.A., Turnell W.G., Volanakis J.E., Pepys M.B., Bloomer A.C., Greenhough T.J. Three-dimensional structure of human C-reactive protein. Nature Structural Biology. 3:1996;346-353.
37. Smalley D.M., Preusch P.C. Analysis of. γ -carboxyglutamic acid by reversed phase HPLC of its phenylthiocarbamyl derivative Analytical Biochemistry. 172:1988;241-247.
38. Stanssens P., Bergum P.W., Gansemans Y., Jespers L., Laroche Y., Huang S., Maki S., Messens J., Lauwereys M., Cappello M., Hotez P.J., Lasters I., Vlasuk G.P. Anticoagulant repertoire of the hookworm Ancylostoma caninum. Proceedings of the National Academy of Science USA. 93:1996;2149-2154.
39. Stark K.R., James A.A. Anticoagulants in vector arthropods. Parasitology Today. 12:1996;4430-4437.
40. van 't Veer C., Mann K.G. Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparin cofactor-II. Journal of Biological Chemistry. 272:1997;4367-4377.