Time-resolved backbone desolvation and mutational hot spots in folding proteins

Proteins: Structure, Function and Genetics

Volumn 47, Issue 4, 2002, Pages 447-457

  Fernández, Ariel ^a,b,c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Ab initio simulations; Chymotrypsin inhibitor 2; Mammalian ubiquitin

Indexed keywords

CHYMOTRYPSIN INHIBITOR; UBIQUITIN;

ALGORITHM; ARTICLE; HYDROGEN BOND; HYDROPHOBICITY; KINETICS; MUTATION; PREDICTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN FOLDING; SIMULATION; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MUTATION; PEPTIDES; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINS; SOLVENTS; UBIQUITIN; WATER;

MAMMALIA;

EID: 0036606868     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10109     Document Type: Article

References (26)

1. De-novo protein design: Fully automated sequence selection
2. Design, structure and stability of a hyperthermophilic protein variant
3. Combinatorial and computational challenges for biocatalyst design
4. Effects of point mutations on the folding of globular proteins
5. The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding
6. Transition state structure as a unifying basis in protein folding mechanisms: Contact order, chain topology, stability and the extended nucleus mechanism
7. Self-organization and mismatch tolerance in protein folding: General theory and an application
8. Topology to geometry in protein folding: Beta-lactoglobulin
9. Conformation-dependent environments in folding proteins
10. Topology to geometry in protein folding: Hierarchical and nonhierarchical scenarios
11. Specific nucleus as the transition state for protein folding: Evidence from the lattice model
12. The nucleation-collapse mechanism in protein folding: Evidence for the non-uniqueness of the folding nucleus
13. Distinguishing between two-state and three-state models for ubiquitin folding
14. D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding
15. The barriers in protein folding
16. Obligatory steps in protein folding and the conformational diversity of the transition state
17. Evidence for a 3-state model of protein folding from kinetic analysis of ubiquitin variants with altered core residues
18. Folding of chymotrypsin inhibitor 2: Evidence for a two-state transition
19. A simple model for calculating the kinetics of protein folding from three-dimensional structures
20. Protein folding intermediates: Native-state hydrogen exchange
21. Effect of preformed correct tertiary interactions on rapid two-state tendamistat folding: Evidence for hairpins an initiation sites for beta-sheet formation
22. Elucidating the folding problem of alpha-helices: Local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters
23. Towards an energy function for the contact map representation of proteins
24. Folding dynamics with nonadditive forces: A simulation study of a designed helical protein and a random heteropolymer
25. AQUA PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
26. Main-chain bond lengths and bond angles in protein structures