-
1
-
-
0028843552
-
Chemotherapy in non-small cell lung cancer. A meta-analysis using updated data on individual patients from 52 randomised clinical trials
-
Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer. A meta-analysis using updated data on individual patients from 52 randomised clinical trials. Br Med J 311: 899-909
-
(1995)
Br Med J
, vol.311
, pp. 899-909
-
-
-
2
-
-
0032887573
-
Mitomycin, Ifosfamide, and Cisplatin in Unresectable Non-Small-Cell Lung Cancer: Effects on Survival and Quality of Life
-
Cullen MH, Billingham U, Woodroffe CM et al. (1999) Mitomycin, Ifosfamide, and Cisplatin in Unresectable Non-Small-Cell Lung Cancer: Effects on Survival and Quality of Life. J Clin Oncol 17: 3188-3194
-
(1999)
J Clin Oncol
, vol.17
, pp. 3188-3194
-
-
Cullen, M.H.1
Billingham, U.2
Woodroffe, C.M.3
-
3
-
-
0006453669
-
Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer
-
The Elderly Lung Cancer, Vinorelbine Italian Study Group (1999) Effects of Vinorelbine on Quality of Life and Survival of Elderly Patients with Advanced Non-Small-Cell Lung Cancer. JNCI 91: 66-72
-
(1999)
JNCI
, vol.91
, pp. 66-72
-
-
-
4
-
-
0033913982
-
Gemcitabine plus best supportive care (BSC) vs. BSC in inoperable non-small cell lung cancer - A randomized trial with quality of life as the primary outcome. UK NSCLC Gemcitabine Group. Non-Small Cell Lung Cancer
-
Anderson H, Hopwood P, Stephens RJ et al. (2000) Gemcitabine plus best supportive care (BSC) vs. BSC in inoperable non-small cell lung cancer - a randomized trial with quality of life as the primary outcome. UK NSCLC Gemcitabine Group. Non-Small Cell Lung Cancer. Br J Cancer 83: 447-453
-
(2000)
Br J Cancer
, vol.83
, pp. 447-453
-
-
Anderson, H.1
Hopwood, P.2
Stephens, R.J.3
-
5
-
-
0034608773
-
Randomized trial of paclitaxel plus suppotive care versus suppotive care for patients with advanced non small cell lung cancer
-
Ranson M, Davidson N, Nicolson M et al. (2000) Randomized trial of Paclitaxel plus Suppotive Care versus Suppotive Care for Patients with Advanced Non Small Cell Lung Cancer, JNCI 92: 1074-1080
-
(2000)
JNCI
, vol.92
, pp. 1074-1080
-
-
Ranson, M.1
Davidson, N.2
Nicolson, M.3
-
6
-
-
0034160108
-
A multicenter, randomized, phase III study of Docetaxel plus best supportive care versus best supportive care in chemotherapynaïve patients with metastatic or nonresectable localized non-small cell lung cancer (NSCLC)
-
Roszkowski K, Pluzanska A, Krzakowski M et al. (2000) A multicenter, randomized, phase III study of Docetaxel plus best supportive care versus best supportive care in chemotherapynaïve patients with metastatic or nonresectable localized non-small cell lung cancer (NSCLC). Lung Cancer 27: 145-157
-
(2000)
Lung Cancer
, vol.27
, pp. 145-157
-
-
Roszkowski, K.1
Pluzanska, A.2
Krzakowski, M.3
-
7
-
-
0025265423
-
Randomized comparison of two combination regimens versus minimal chemotherapy in non small cell lung cancer: A Southeastern Cancer Study Group Trial
-
Luedke DW, Einhorn L, Omura GA et al. (1990) Randomized Comparison of Two Combination Regimens Versus Minimal Chemotherapy in Non Small Cell Lung Cancer: A Southeastern Cancer Study Group Trial. J Clin Oncol 8: 886-891
-
(1990)
J Clin Oncol
, vol.8
, pp. 886-891
-
-
Luedke, D.W.1
Einhorn, L.2
Omura, G.A.3
-
8
-
-
0025313120
-
Etoposide versus etoposide plus high-dose cisplatin in the management of advanced non-small cell lung cancer
-
Rosso R, Salvati F, Ardizzoni A et al. (1990) Etoposide Versus Etoposide Plus High-Dose Cisplatin in the Management of Advanced Non-Small Cell Lung Cancer. Cancer 66: 130-134
-
(1990)
Cancer
, vol.66
, pp. 130-134
-
-
Rosso, R.1
Salvati, F.2
Ardizzoni, A.3
-
9
-
-
0024312867
-
Cisplatin versus cisplatin plus etoposide in the treatment of advanced non-small cell lung cancer
-
Klastersky J, Sculier JP, Bureau G et al. (1989) Cisplatin Versus Cisplatin Plus Etoposide in the Treatment of Advanced Non-Small Cell Lung Cancer. J Clin Oncol 7: 1087-1092
-
(1989)
J Clin Oncol
, vol.7
, pp. 1087-1092
-
-
Klastersky, J.1
Sculier, J.P.2
Bureau, G.3
-
10
-
-
0024272753
-
Treatment of advanced non-small cell lung cancer (NSCLC): The "Umbria" Cooperative Study
-
Crino L, Darwish S, Corgna E et al.(1988) Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC): The "Umbria" Cooperative Study. Semin Oncol 15(Suppl 7): 52-55
-
(1988)
Semin Oncol
, vol.15
, Issue.SUPPL. 7
, pp. 52-55
-
-
Crino, L.1
Darwish, S.2
Corgna, E.3
-
11
-
-
0025948264
-
A randomized study of cisplatin versus cisplatin plus vindesine for non-small cell lung carcinoma
-
Kawahara M, Furuse K, Kodama N et al. (1991) A Randomized Study of Cisplatin versus Cisplatin plus Vindesine for Non-Small Cell Lung Carcinoma. Cancer 68: 714-719
-
(1991)
Cancer
, vol.68
, pp. 714-719
-
-
Kawahara, M.1
Furuse, K.2
Kodama, N.3
-
12
-
-
0025735389
-
A randomized trial of five cisplatin-containing treatments in patients with metastatic nonsmall cell lung cancer: A Southwest Oncology Group Study
-
JK, Crowley J, Natale RB et al. (1991) A Randomized Trial of Five Cisplatin-Containing Treatments in Patients with metastatic NonSmall Cell Lung Cancer: A Southwest Oncology Group Study. J Clin Oncol 9: 1157-1162
-
(1991)
J Clin Oncol
, vol.9
, pp. 1157-1162
-
-
Crowley, J.1
Natale, R.B.2
-
13
-
-
0022640642
-
A randomized trial of the four most active regimens for metastatic nonsmall cell lung cancer
-
Ruckdeschel JC, Finkelstein DM, Ettinger DS et al. (1986) A Randomized Trial of the four most active Regimens for metastatic NonSmall Cell Lung Cancer. J Clin Oncol 4: 14-22
-
(1986)
J Clin Oncol
, vol.4
, pp. 14-22
-
-
Ruckdeschel, J.C.1
Finkelstein, D.M.2
Ettinger, D.S.3
-
14
-
-
0024426659
-
Combination chemotherapy versus single agents followed by combination chemotherapy in stage IV non-small cell lung cancer: A Study of the Eastern Cooperative Oncology Group
-
Bonomi PD, Finkelstein DM, Ruckdeschel JC et al. (1989) Combination Chemotherapy versus Single Agents followed by Combination Chemotherapy in Stage IV Non-Small Cell Lung Cancer: A Study of the Eastern Cooperative Oncology Group. J Clin Oncol 7: 1602-1613
-
(1989)
J Clin Oncol
, vol.7
, pp. 1602-1613
-
-
Bonomi, P.D.1
Finkelstein, D.M.2
Ruckdeschel, J.C.3
-
15
-
-
0025336842
-
Chemotherapie des fortgeschrittenen nichtkleinzelligen bronchialkarzinoms mit mitomycin-C/ifosfamid versus mitomycin-C/vindesin versus cisplatin/etoposid - Eine prospektiv randomisierte studie
-
Gatzemeier U, Heckmayr M, Hossfeld DK et al. (1990) Chemotherapie des fortgeschrittenen nichtkleinzelligen Bronchialkarzinoms mit Mitomycin-C/Ifosfamid versus Mitomycin-C/Vindesin versus Cisplatin/Etoposid - Eine prospektiv randomisierte Studie. Pneumologie 44: 258-260
-
(1990)
Pneumologie
, vol.44
, pp. 258-260
-
-
Gatzemeier, U.1
Heckmayr, M.2
Hossfeld, D.K.3
-
16
-
-
0025146178
-
A randomized study comparing cisplatin or carboplatin with etoposide in patients with advanced non-small cell lung cancer: European Organization for Research and Treatment of Cancer Protocol 07861
-
Klastersky J, Sculier JP, Lacroix H et al. (1990) A Randomized Study Comparing Cisplatin or Carboplatin with Etoposide in Patients with advanced Non-Small Cell Lung Cancer: European Organization for Research and Treatment of Cancer Protocol 07861. J Clin Oncol 8: 1556-1562
-
(1990)
J Clin Oncol
, vol.8
, pp. 1556-1562
-
-
Klastersky, J.1
Sculier, J.P.2
Lacroix, H.3
-
17
-
-
0028923089
-
Chemotherapy of advanced non-small cell lung cancer: A comparison of three active regimens. A randomized trial of the Italian Oncology Group for Clinical Research (G.O.I.R.C.)
-
Crino L, Clerici M, Figoli F et al (1995) Chemotherapy of advanced non-small cell lung cancer: A comparison of three active regimens. A randomized trial of the Italian Oncology Group for Clinical Research (G.O.I.R.C.). Ann Oncol 6: 347-353
-
(1995)
Ann Oncol
, vol.6
, pp. 347-353
-
-
Crino, L.1
Clerici, M.2
Figoli, F.3
-
18
-
-
0027412646
-
A Phase II Study of Taxol (NSC 125973) in Patients with untreated advanced Non-Small Cell Lung Cancer
-
Murphy WK, Fossella FU,Winn RJ et al. (1993) A Phase II Study of Taxol (NSC 125973) in Patients with untreated advanced Non-Small Cell Lung Cancer. J Natl Cancer Inst 85: 384-388
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 384-388
-
-
Murphy, W.K.1
Fossella, F.U.2
Winn, R.J.3
-
19
-
-
0012811377
-
Development of paclitaxel and review of US and European Phase II Data in Lung Cancer
-
Prague, 28.-31.05
-
Gatzemeier U (1995) Development of Paclitaxel and Review of US and European Phase II Data in Lung Cancer. 3rd Central European Lung Cancer Conference, Prague, 28.-31.05.
-
(1995)
3rd Central European Lung Cancer Conference
-
-
Gatzemeier, U.1
-
20
-
-
0029003733
-
Paclitaxel by 1-hour infusion: An active drug in metastatic non-small cell lung cancer
-
Hainsworth JD, Thompson DG, Greco FA et al. (1995) Paclitaxel by 1-Hour Infusion: An Active Drug in Metastatic Non-Small Cell Lung Cancer. J CliniOncol 13: 1609-1614
-
(1995)
J CliniOncol
, vol.13
, pp. 1609-1614
-
-
Hainsworth, J.D.1
Thompson, D.G.2
Greco, F.A.3
-
21
-
-
0031972610
-
Phase I trial of weekly paclitaxel in advanced lung cancer
-
Akerly W, Glantz M, Choy H et al. (1998) Phase I Trial of Weekly Paclitaxel in Advanced Lung Cancer. J Clin Oncol 16: 153-158
-
(1998)
J Clin Oncol
, vol.16
, pp. 153-158
-
-
Akerly, W.1
Glantz, M.2
Choy, H.3
-
22
-
-
0028944053
-
Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer
-
Fossella FV, Lee JS, Shin DM et al. (1995) Phase II Study of Docetaxel for Advanced or Metastatic Platinum-Refractory Non-Small-Cell Lung Cancer. J Clin Oncol 13: 645-651
-
(1995)
J Clin Oncol
, vol.13
, pp. 645-651
-
-
Fossella, F.V.1
Lee, J.S.2
Shin, D.M.3
-
23
-
-
85009011166
-
Phase II trial of docetaxel foradvanced non-small-cell lung cancer (NSCLC)
-
abs. 1886
-
Kim NK, Park K, Park CH et al. (1998) Phase II Trial of Docetaxel foradvanced Non-Small-Cell Lung Cancer (NSCLC). Proc ASCO 17, abs. 1886
-
(1998)
Proc ASCO
, vol.17
-
-
Kim, N.K.1
Park, K.2
Park, C.H.3
-
24
-
-
0029913666
-
Phase II trial of docetaxel in previously untreated advanced non-small cell lung cancer: A Japanese cooperative study
-
Kunitoh H, Watanabe K, Onoshi T et al. (1996) Phase II Trial of Docetaxel in Previously Untreated Advanced Non-Small Cell Lung Cancer: A Japanese Cooperative Study. J Clin Oncol 14: 1649-1655
-
(1996)
J Clin Oncol
, vol.14
, pp. 1649-1655
-
-
Kunitoh, H.1
Watanabe, K.2
Onoshi, T.3
-
25
-
-
0012234287
-
Single agent gemcitabine (G) and docetaxel (D) Given sequentially in various doses and schedules are effective in advanced NSCLC: Survival data from two (I,II) randomized phase II studies
-
abstr. 1346
-
Manegold C, Pilz L, Koschel K et al. (2001) Single Agent Gemcitabine (G) and Docetaxel (D) Given Sequentially in Various Doses and Schedules Are Effective in Advanced NSCLC: Survival Data from Two (I,II) Randomized Phase II Studies. Proc ASCO 20, abstr. 1346, p 337a
-
(2001)
Proc ASCO
, vol.20
-
-
Manegold, C.1
Pilz, L.2
Koschel, K.3
-
26
-
-
0027993707
-
Efficacy and safety profile of gemcitabine in non-small cell lung cancer: A phase II study
-
Abratt RP, Bezwoda WR, Falkson G et al. (1994) Efficacy and safety profile of gemcitabine in non-small cell lung cancer: a phase II study. J Clin Oncol 12: 1535-1450
-
(1994)
J Clin Oncol
, vol.12
, pp. 1535-1450
-
-
Abratt, R.P.1
Bezwoda, W.R.2
Falkson, G.3
-
27
-
-
0028033227
-
Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: A phase II study
-
Anderson H, Lund B, Bach F, Thatcher N, Walling J, Hansen HH (1994) Single-Agent Activity of Weekly Gemcitabine in Advanced Non-Small-Cell Lung Cancer: A Phase II Study. J Clin Oncol 12: 1821-1826
-
(1994)
J Clin Oncol
, vol.12
, pp. 1821-1826
-
-
Anderson, H.1
Lund, B.2
Bach, F.3
Thatcher, N.4
Walling, J.5
Hansen, H.H.6
-
28
-
-
0012856227
-
A multicenter Phase II trial with gemcitabine in non small cell lung cancer (NSCLC)
-
abstr 461
-
Gatzemeier U, Shephard F, Le Chevalier T et al. (1994) A multicenter Phase II trial with gemcitabine in non small cell lung cancer (NSCLC). Lung Cancer 11 (Suppl 1) 121 abstr 461
-
(1994)
Lung Cancer
, vol.11
, Issue.SUPPL. 1
, pp. 121
-
-
Gatzemeier, U.1
Shephard, F.2
Le Chevalier, T.3
-
29
-
-
0027952504
-
Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung cancer: A randomized trial
-
Depierre A, Chastang CI, Quoix E et al. (1994) Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung cancer: A randomized trial. Annals of Oncology 5: 37-42
-
(1994)
Annals of Oncology
, vol.5
, pp. 37-42
-
-
Depierre, A.1
Chastang, C.I.2
Quoix, E.3
-
30
-
-
10144246570
-
Randomized trial of vinorelbine compared with fluorouracil plus leucovorin in patients with stage IV non-small cell lung cancer
-
Crawford J, O'Rourke M, Schiller JH et al. (1996) Randomized Trial of Vinorelbine Compared With Fluorouracil Plus Leucovorin in Patients With Stage IV Non-Small Cell Lung Cancer. J Clin Oncol 14: 2774-2784
-
(1996)
J Clin Oncol
, vol.14
, pp. 2774-2784
-
-
Crawford, J.1
O'Rourke, M.2
Schiller, J.H.3
-
31
-
-
10244229739
-
Randomized study of vinorelbine (VRB) versus (VDS) in previously untreated stage IIIB or IV non-small cell lung cancer (NSCLC)
-
Furuse K, Fukuoka M, Kuba M et al.(1996) Randomized study of vinorelbine (VRB) versus (VDS) in previously untreated stage IIIB or IV non-small cell lung cancer (NSCLC). Ann Oncol 7: 815-820
-
(1996)
Ann Oncol
, vol.7
, pp. 815-820
-
-
Furuse, K.1
Fukuoka, M.2
Kuba, M.3
-
32
-
-
0026531753
-
A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer
-
Fukuoka H, Niitani H, Suzuki A et al. (1992) A Phase II Study of CPT-11, a New Derivative of Camptothecin, for Previously Untreated Non-Small-Cell Lung Cancer. J Clin Oncol 10: 16-20
-
(1992)
J Clin Oncol
, vol.10
, pp. 16-20
-
-
Fukuoka, H.1
Niitani, H.2
Suzuki, A.3
-
33
-
-
0004484604
-
Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapy
-
Perez-Soler R, Fossella FV, Glisson B.S et al. (1996) Phase II Study of Topotecan in Patients with Advanced Non-Small-Cell Lung Cancer Previously Untreated With Chemotherapy. J Clin Oncol 14:503-513
-
(1996)
J Clin Oncol
, vol.14
, pp. 503-513
-
-
Perez-Soler, R.1
Fossella, F.V.2
Glisson, B.S.3
-
34
-
-
0034062220
-
Phase II study of oral Topotecan in advanced non-small cell lung cancer
-
White SC, Cheeseman S, Thatcher N et al. (2000) Phase II study of oral Topotecan in advanced non-small cell lung cancer. Clin Cancer Res 6: 868-873
-
(2000)
Clin Cancer Res
, vol.6
, pp. 868-873
-
-
White, S.C.1
Cheeseman, S.2
Thatcher, N.3
-
35
-
-
0032908148
-
Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: A phase II study
-
Rustoven JJ, Eisenhauser E, Butts C et al. (1999) Multitargeted Antifolate LY231514 as First-Line Chemotherapy for Patients With Advanced Non-Small-Cell Lung Cancer: A Phase II Study. J Clin Oncol 17: 1194-1199
-
(1999)
J Clin Oncol
, vol.17
, pp. 1194-1199
-
-
Rustoven, J.J.1
Eisenhauser, E.2
Butts, C.3
-
36
-
-
0032103861
-
Phase II study of oxaliplatin in poo-prognosis Non-small Cell Lung Cancer (NSCLC)
-
Monnet I, Brienza S, Hugret F et al. (1998) Phase II Study of Oxaliplatin in Poo-prognosis Non-Small Cell Lung Cancer (NSCLC). Eur J Cancer 37: 1124-1127
-
(1998)
Eur J Cancer
, vol.37
, pp. 1124-1127
-
-
Monnet, I.1
Brienza, S.2
Hugret, F.3
-
37
-
-
0034306321
-
Phase III comparative study of high dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer
-
Gatzemeier U, von Pawel J, Gottfried M et al. (2000) Phase III Comparative Study of High Dose Cisplatin Versus a Combination of Paclitaxel and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer. J Clin Oncol 18: 3390-3399
-
(2000)
J Clin Oncol
, vol.18
, pp. 3390-3399
-
-
Gatzemeier, U.1
Von Pawel, J.2
Gottfried, M.3
-
38
-
-
0032739808
-
Single-agent Gemcitabine: An active and better tolerated alternative to standard cisplatin-based chemotherapy in locally advanced or metastatic non-small cell lung cancer
-
ten Bokkel Huinink WW, Bergman B, Chemaissani A et al. (1999) Single-agent Gemcitabine: an active and better tolerated alternative to standard cisplatin-based chemotherapy in locally advanced or metastatic non-small cell lung cancer. Lung Cancer 26: 85-94
-
(1999)
Lung Cancer
, vol.26
, pp. 85-94
-
-
Ten Bokkel Huinink, W.W.1
Bergman, B.2
Chemaissani, A.3
-
39
-
-
0003355287
-
Symptom control in advanced Non-small Cell Lung Cancer (NSCLC): A multicenter prospektive randomized phase III study of single agent gemcitabine (GEM) versus cisplatin-vindesine (PV)
-
abstr 1910
-
Vansteenkiste J, Vandebroek J, Nackaerts K et al. (2000): Symptom Control in Advanced Non-Small Cell Lung Cancer (NSCLC): A Multicenter Prospektive Randomized Phase III Study of Single Agent Gemcitabine (GEM) Versus Cisplatin-Vindesine (PV). Proc ASCO 19, abstr. 1910
-
(2000)
Proc ASCO
, vol.19
-
-
Vansteenkiste, J.1
Vandebroek, J.2
Nackaerts, K.3
-
40
-
-
0001353278
-
Phase III study of cisplatin (C) with or without gemcitabine (G) in patients with advanced non-small cell lung cancer (NSCLC)
-
abstr 1747
-
Sandler A, Nemunaitis J, Dehnam C et al. (1998) Phase III study of cisplatin (C) with or without gemcitabine (G) in patients with advanced non-small cell lung cancer (NSCLC). Proc ASCO 17, abstr. 1747
-
(1998)
Proc ASCO
, vol.17
-
-
Sandler, A.1
Nemunaitis, J.2
Dehnam, C.3
-
41
-
-
0028154069
-
Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients
-
LeChevalier T, Brisgand D, Douillard JY et al. (1994) Randomized Study of Vinorelbine and Cisplatin Versus Vindesine and Cisplatin Versus Vinorelbine Alone in Advanced Non-Small-Cell Lung Cancer: Results of a European Multicenter Trial Including 612 Patients. J Clin Oncol 12: 360-367
-
(1994)
J Clin Oncol
, vol.12
, pp. 360-367
-
-
LeChevalier, T.1
Brisgand, D.2
Douillard, J.Y.3
-
42
-
-
0000200373
-
Randomized phase III trial of cisplatin (CDDP) vs CDDP plus navelbine (NVB) in treatment of advanced non-small lung cancer (NSCLC): An update of a Southwest Oncology Group study (SWOG-9308)
-
abstr 1744
-
Wozniak AJ, Crowley JJ, Balcerzak SP et al. (1998): Randomized phase III trial of cisplatin (CDDP) vs CDDP plus navelbine (NVB) in treatment of advanced non-small lung cancer (NSCLC): an update of a Southwest Oncology Group study (SWOG-9308). Proc ASCO, Vol 17, abstr. 1744
-
(1998)
Proc ASCO
, vol.17
-
-
Wozniak, A.J.1
Crowley, J.J.2
Balcerzak, S.P.3
-
43
-
-
0000437978
-
Randomized trial comparing cisplatin (cddp) and irinotecan (CPT-11) versus CDDP and vindesine (VDS) versus CPT-11 alone in advanced Non-small Cell Lung Cancer (NSCLC), a multicenter phase III study
-
abstr 1774
-
Masuda N, Fukooka M, Negoro S et al. (1999) Randomized Trial Comparing Cisplatin (CDDP) and Irinotecan (CPT-11) Versus CDDP and Vindesine (VDS) Versus CPT-11 Alone in Advanced Non-Small Cell Lung Cancer (NSCLC), a Multicenter Phase III Study. Proc ASCO 18, abstr. 1774
-
(1999)
Proc ASCO
, vol.18
-
-
Masuda, N.1
Fukooka, M.2
Negoro, S.3
-
44
-
-
0034104328
-
Tirapazamine plus cisplatin versus cisplatin in advanced non-small cell lung cancer: A report of the international CATAPULT 1 study group
-
yon Pawel J, von Roemeling R, Gatzemeier U et al. (2000) Tirapazamine Plus Cisplatin Versus Cisplatin in Advanced Non-Small Cell Lung Cancer: A Report of the International CATAPULT 1 Study Group. J Clin Oncol 18: 1351-1359
-
(2000)
J Clin Oncol
, vol.18
, pp. 1351-1359
-
-
Yon Pawel, J.1
Von Roemeling, R.2
Gatzemeier, U.3
-
45
-
-
0033950286
-
Comparison of survival and quality of life in advanced non-small cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an Eastern Cooperative Oncology Group TriaI
-
Bonomi P, Kim K, Fairclough, D et al. (2000) Comparison of survival and quality of Life in Advanced Non-Small Cell Lung Cancer Patients Treated with two Dose Levels of Paclitaxel Combined With Cisplatin Versus Etoposide With Cisplatin: Results of an Eastern Cooperative Oncology Group TriaI. J Clin Oncol 18: 623-631
-
(2000)
J Clin Oncol
, vol.18
, pp. 623-631
-
-
Bonomi, P.1
Kim, K.2
Fairclough, D.3
-
46
-
-
0031779533
-
Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer
-
Giaccone, G, Splinter, TAW, Debruyne C et al. (1998) Randomized Study of Paclitaxel-Cisplatin Versus Cisplatin-Teniposide in Patients With Advanced Non-Small-Cell Lung Cancer. J Clin Oncol 16: 2133-2141
-
(1998)
J Clin Oncol
, vol.16
, pp. 2133-2141
-
-
Giaccone, G.1
Splinter, T.A.W.2
Debruyne, C.3
-
47
-
-
0000339576
-
Randomized phase III trial comparing cisplatin/etoposide versus carboplatin/paclitaxel in advanced and metastatic non-small-cell lung cancer
-
abstr 1751
-
Belani CP, Natale RB, Lee JS et al. (1998) Randomized Phase III Trial Comparing Cisplatin/Etoposide versus Carboplatin/Paclitaxel in advanced and metastatic Non-Small-Cell Lung Cancer. Proc ASCO 17, abstr. 1751
-
(1998)
Proc ASCO
, vol.17
-
-
Belani, C.P.1
Natale, R.B.2
Lee, J.S.3
-
48
-
-
0000510626
-
A randomized phase III trial of paclitaxel plus carboplatin (PC) versus vinorelbine plus cisplatin (VC) in untreated advanced Non-small Cell Lung Cancer (NSCLC): A Southwest Oncology Group (SWOG) Trial
-
abstr 1777
-
Kelly K, Crowley J, Bunn PA et al. (1999) A Randomized Phase III Trial of Paclitaxel Plus Carboplatin (PC) Versus Vinorelbine Plus Cisplatin (VC) in Untreated Advanced Non-SmallCell Lung Cancer (NSCLC): A Southwest Oncology Group (SWOG) Trial. Proc ASCO 18, abstr. 1777
-
(1999)
Proc ASCO
, vol.18
-
-
Kelly, K.1
Crowley, J.2
Bunn, P.A.3
-
49
-
-
0000012871
-
A multicenter randomized phase III study of Docetaxel + Cisplatin (DC) and Docetaxel + Carboplatin (DCB) vs Vinorelbine + Cisplatin (VC) in chemotherapy naive patients with advanced and metastatic non-small cell lung cancer (NSCLC)
-
abstr 1252
-
Rodriguez J, Pawel J, Pluzanska A et al. (2001) A Multicenter Randomized Phase III Study of Docetaxel + Cisplatin (DC) and Docetaxel + Carboplatin (DCB) vs Vinorelbine + Cisplatin (VC) in Chemotherapy Naive Patients with Advanced and Metastatic Non-Small Cell Lung Cancer (NSCLC). Procs ASCO 20, abstr. 1252
-
(2001)
Procs ASCO
, vol.20
-
-
Rodriguez, J.1
Pawel, J.2
Pluzanska, A.3
-
50
-
-
0000829637
-
Preliminary results aof a randomised phase III trial of docetaxel (D) and cisplatin (P) versus vindesine (V) and P in stage IV non-small cell lung cancer (NSCLC)
-
abstr 12891
-
Kunitoh H, Watanabe K, Ohashi Y et al. (2001) Preliminary results aof a randomised phase III trial of docetaxel (D) and cisplatin (P) versus vindesine (V) and P in stage IV non-small cell lung cancer (NSCLC). Proc ASCO 20, abstr. 12891
-
(2001)
Proc ASCO
, vol.20
-
-
Kunitoh, H.1
Watanabe, K.2
Ohashi, Y.3
-
51
-
-
0035849269
-
Platinum based and non-platinum-based chemotherapy in advanced non-small cell lung cancer: A randomised multicentre trial
-
Georgoulias V, Papadakis E, Alexopoulos A et al. (2001) Platinum based and non-platinum-based chemotherapy in advanced non-small cell lung cancer: a randomised multicentre trial. Lancet 357: 1478-1484
-
(2001)
Lancet
, vol.357
, pp. 1478-1484
-
-
Georgoulias, V.1
Papadakis, E.2
Alexopoulos, A.3
-
52
-
-
0032701095
-
Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: A randomized Phase III Study of the Italian Lung Cancer Project
-
Crino L, Scagliotti G.V. Ricci S et al. (1999) Gemcitabine and Cisplatin versus Mitomycin, Ifosfamide, and Cisplatin in Advanced Non-Small-Cell Lung Cancer: A randomized Phase III Study of the Italian Lung Cancer Project. J Clin Oncol 17: 3522-3530
-
(1999)
J Clin Oncol
, vol.17
, pp. 3522-3530
-
-
Crino, L.1
Scagliotti, G.V.2
Ricci, S.3
-
53
-
-
0345148774
-
Randomized phase III study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small cell lung cancer
-
Cardenal F, Paz Lopez-Cabrerizo M, Anton A et al. (1999) Randomized Phase III Study of Gemcitabine-Cisplatin Versus Etoposide-Cisplatin in the Treatment of Locally Advanced or Metastatic Non-Small Cell Lung Cancer. J Clin Oncol 17: 12-18
-
(1999)
J Clin Oncol
, vol.17
, pp. 12-18
-
-
Cardenal, F.1
Paz Lopez-Cabrerizo, M.2
Anton, A.3
-
54
-
-
0037050352
-
Comparison of four chemotherapy regimens for adanced non-small cell lung cancer
-
Schiller, JH, Harrington D, Belani CP et al. (2002) Comparison of four Chemotherapy Regimens for adanced Non-Small Cell Lung Cancer. N Engl J Med 346: 92-98
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
55
-
-
0036843105
-
Phase III randomized trial comparing three platinum based doublets in advanced non-small cell lung cancer
-
abstr 1227
-
Scagliotti GV, De Marinis F, Rinaldi M et al. (2001) Phase III Randomized Trial Comparing Three Platinum Based Doublets in Advanced Non-Small Cell Lung Cancer. Proc ASCO 20, abstr. 1227
-
(2001)
Proc ASCO
, vol.20
-
-
Scagliotti, G.V.1
De Marinis, F.2
Rinaldi, M.3
-
56
-
-
0034076846
-
Randomized trial comparing cisplatin, gemcitabine, and vinorelbine with either cisplatin and gemicitabine or cisplatin and vinorelbine in advanced non-small-cell lung cancer: Interim analysis of a phase III trial of the Southern Italy Cooperative Oncology Group
-
Comella P, Frasci G, Panza N et al. (2000) Randomized Trial Comparing Cisplatin, Gemcitabine, and Vinorelbine With Either Cisplatin and Gemicitabine or Cisplatin and Vinorelbine in Advanced Non-Small-Cell Lung Cancer: Interim Analysis of a Phase III Trial of the Southern Italy Cooperative Oncology Group. J Clin Oncol 18: 1451-1457
-
(2000)
J Clin Oncol
, vol.18
, pp. 1451-1457
-
-
Comella, P.1
Frasci, G.2
Panza, N.3
-
57
-
-
0003319867
-
Cisplatin-Gemcitabine vs Cisplatin-Gemcitabine-Vinorelbine vs Cisplatin-Gemcitabine-Paclitaxel in Advanced Non-Small-Cell Lung Cancer. First Stage Analysis of a Southern Italy Cooperative Oncology Group (SICOG) Phase III Trial
-
abs 1933
-
Comella G, Comella P, Frasci G et al. (2000) Cisplatin-Gemcitabine vs Cisplatin-Gemcitabine-Vinorelbine vs Cisplatin-Gemcitabine-Paclitaxel in Advanced Non-Small-Cell Lung Cancer. First Stage Analysis of a Southern Italy Cooperative Oncology Group (SICOG) Phase III Trial. Proc ASCO, Vol. 19, abs. 1933.
-
(2000)
Proc ASCO
, vol.19
-
-
Comella, G.1
Comella, P.2
Frasci, G.3
-
58
-
-
0000808695
-
Cisplatin/Gemcitabine (CG) vs Cisplatin/Gemcitabine/Vinorelbine (CGV) vs Sequential Doublets of Gemcitabine/Vinorelbine Followed by Ifosfamide/Vinorelbine (GV/IV) in Advanced Non-Small Cell Lung Cancer (NSCLC): Results of a Spanish Lung Cancer Group Phase III Trial (GEPC/98-02)
-
abstr 1229
-
Alberola V, Camps C, Provencia M et al. (2001) Cisplatin/Gemcitabine (CG) vs Cisplatin/Gemcitabine/Vinorelbine (CGV) vs Sequential Doublets of Gemcitabine/Vinorelbine Followed by Ifosfamide/Vinorelbine (GV/IV) in Advanced Non-Small Cell Lung Cancer (NSCLC): Results of a Spanish Lung Cancer Group Phase III Trial (GEPC/98-02). Proc ASCO 20,abstr. 1229
-
(2001)
Proc ASCO
, vol.20
-
-
Alberola, V.1
Camps, C.2
Provencia, M.3
-
59
-
-
0003316161
-
Glob 1: Final results of a prospective randomized phase III Trial Comparing Vinorelbine and Cisplatin (NP) Versus Vinorelbine, Ifosfamide, and Cisplatin (NIP) in Metastatic Non Small Cell Lung Cancer (NSCLC) Patients (pts)
-
abstr. 1299
-
Tan E, Souquet J, Pereira R et al. (2001) Glob 1: Final Results of a Prospective Randomized Phase III Trial Comparing Vinorelbine and Cisplatin (NP) Versus Vinorelbine, Ifosfamide, and Cisplatin (NIP) in Metastatic Non Small Cell Lung Cancer (NSCLC) Patients (pts). Proc ASCO 20, abstr. 1299, p 326a
-
(2001)
Proc ASCO
, vol.20
-
-
Tan, E.1
Souquet, J.2
Pereira, R.3
-
60
-
-
0000693891
-
A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Paclitaxel Plus Gemcitabine in Advanced Non Small Cell Lung Cancer (NSCLC). A Preliminary Analysis
-
abstr 1908
-
Kosmidis PA, Bacoyiannis C, Mylonakis N et al. (2000): A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Paclitaxel Plus Gemcitabine in Advanced Non Small Cell Lung Cancer (NSCLC). A Preliminary Analysis. Proc ASCO 19, abstr. 1908
-
(2000)
Proc ASCO
, vol.19
-
-
Kosmidis, P.A.1
Bacoyiannis, C.2
Mylonakis, N.3
-
61
-
-
0000828452
-
A EORTC randomized phase III trial of three chemotherapy regimens in advanced Non-Small Cell Lung Cancer (NSCLC)
-
abstr 1228
-
Van Meerbeek JR, Smit EF, Lianes P et al. (2001) A EORTC Randomized Phase III Trial of Three Chemotherapy Regimens in Advanced Non-Small Cell Lung Cancer (NSCLC). Proc ASCO 20, abstr. 1228
-
(2001)
Proc ASCO
, vol.20
-
-
Van Meerbeek, J.R.1
Smit, E.F.2
Lianes, P.3
-
62
-
-
4244154628
-
Phase II multicenter randomized trial of weekly paclitaxel (P) administered in combination with carboplatin (C) Followed by maintenance P Vs. observation for patients (pts) with advanced & metastatic Non-small Cell Lung Cancer (NSCLC)
-
abstr. 1287
-
Belani C, Barstis M, Perry R et al. (2001) Phase II Multicenter Randomized Trial of Weekly Paclitaxel (P) Administered in Combination with Carboplatin (C) Followed by Maintenance P Vs. Observation for Patients (pts) with Advanced & Metastatic Non-Small Cell Lung Cancer (NSCLC). Proc ASCO 20, abstr. 1287, p 323a
-
(2001)
Proc ASCO
, vol.20
-
-
Belani, C.1
Barstis, M.2
Perry, R.3
-
63
-
-
0028944053
-
Phase II study of docetaxel for advanced or metastatic platinum-refractory non-small-cell lung cancer
-
Fossella FV, Lee JS, Shin DM et al. (1995) Phase II Study of Docetaxel for Advanced or Metastatic Platinum-Refractory Non-Small-Cell Lung Cancer. J Clin Oncol 13: 645-651
-
(1995)
J Clin Oncol
, vol.13
, pp. 645-651
-
-
Fossella, F.V.1
Lee, J.S.2
Shin, D.M.3
-
64
-
-
0032982848
-
Gemcitabine as second-line treatment for advanced non-small cell lung cancer: A phase II trial
-
Crino L, Mosconi AM, Scagliotti G et al. (1999) Gemcitabine as Second-Line Treatment for Advanced Non-Small Cell Lung Cancer: A Phase II Trial. J Clin Oncol 17: 2081-2085
-
(1999)
J Clin Oncol
, vol.17
, pp. 2081-2085
-
-
Crino, L.1
Mosconi, A.M.2
Scagliotti, G.3
-
65
-
-
0034069620
-
Prospective randomized trial of docetaxel versus best supportive care in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy
-
Shephard F, Dancey J, Ramlau R et al. (2000) Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients with Non-Small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy. J Clin Oncol 18: 2095-2103
-
(2000)
J Clin Oncol
, vol.18
, pp. 2095-2103
-
-
Shephard, F.1
Dancey, J.2
Ramlau, R.3
-
67
-
-
0024996201
-
Counting the costs of chemotherapy in a National Cancer Institute of Canada randomized trial in nonsmall-cell lung Cancer
-
Joakkimainen L, Goodwin PJ, Pater J et al. (1990) Counting the Costs of Chemotherapy in a National Cancer Institute of Canada Randomized Trial in Nonsmall-Cell Lung Cancer. J Clin Oncol 8: 1301-1309
-
(1990)
J Clin Oncol
, vol.8
, pp. 1301-1309
-
-
Joakkimainen, L.1
Goodwin, P.J.2
Pater, J.3
-
68
-
-
0032587583
-
Cost-effectiveness of paclitaxel plus cisplatin in advanced non-small cell lung cancer
-
Earle CC, Evans WK (1999) Cost-effectiveness of paclitaxel plus cisplatin in advanced non-small cell lung cancer. BJC 80: 808-814
-
(1999)
BJC
, vol.80
, pp. 808-814
-
-
Earle, C.C.1
Evans, W.K.2
-
69
-
-
0032407104
-
Economic issues in lung cancer: A review
-
Goodwin PJ, Shephard FA (1998) Economic Issues in Lung Cancer: A Review. J Clin Oncol 16: 3900-3912
-
(1998)
J Clin Oncol
, vol.16
, pp. 3900-3912
-
-
Goodwin, P.J.1
Shephard, F.A.2
-
70
-
-
85009014121
-
Economic analysis of TAX 317: Docetaxel Vs. Best Supportive Care (BSC) for Second-Line Management of Advanced Non-Small Cell Lung Cancer (NSCLC)
-
abstr 1291
-
Leighl NB, Shephard FA, Kwong R et al. (2001) Economic Analysis of TAX 317: Docetaxel Vs. Best Supportive Care (BSC) for Second-Line Management of Advanced Non-Small Cell Lung Cancer (NSCLC). Proc ASCO 20, abstr. 1291
-
(2001)
Proc ASCO
, vol.20
-
-
Leighl, N.B.1
Shephard, F.A.2
Kwong, R.3
-
71
-
-
0034674899
-
Decision framework for chemotherapeutic interventions for metastatic non-small cell lung cancer
-
Berthelot JM, Will BP, Evan K et al. (2000) Decision Framework for Chemotherapeutic Interventions for Metastatic Non-Small Cell Lung Cancer. J Natl Cancer Inst 92: 1321-1329
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1321-1329
-
-
Berthelot, J.M.1
Will, B.P.2
Evan, K.3
-
72
-
-
0029006813
-
Trials with mitomycin, ifosfamide and cisplatin in non-small cell lung cancer
-
Cullen MH (1995) Trials with mitomycin, ifosfamide and cisplatin in non-small cell lung cancer. Lung Cancer 12: 95-106
-
(1995)
Lung Cancer
, vol.12
, pp. 95-106
-
-
Cullen, M.H.1
-
73
-
-
0029097248
-
Does knowledge guide practice? Another look at the management of non-small cell lung cancer
-
Raby B, Pater J, Mackillop WJ (1995) Does Knowledge Guide Practice? Another Look at the Management of Non-Small Cell Lung Cancer. J Clin Oncol 13: 1904-1911
-
(1995)
J Clin Oncol
, vol.13
, pp. 1904-1911
-
-
Raby, B.1
Pater, J.2
Mackillop, W.J.3
-
74
-
-
0032547529
-
Preferences for chemotherapy in patients with advanced non-small cell lung cancer: Descriptive study based on scripted interviews
-
Silvestri G, Pritchard R, Welch HG (1998) Preferences for chemotherapy in patients with advanced non-small cell lung cancer: descriptive study based on scripted interviews. BMJ 317: 771-775
-
(1998)
BMJ
, vol.317
, pp. 771-775
-
-
Silvestri, G.1
Pritchard, R.2
Welch, H.G.3
-
75
-
-
0035698002
-
Do all patients with advanced non-small cell lung cancer benefit from cisplatin-based combination therapy?
-
Soria JC, Brisgand D, LeChevalier T (2001) Do all patients with advanced non-small cell lung cancer benefit from cisplatin-based combination therapy? Ann Oncol 12: 1667-1670
-
(2001)
Ann Oncol
, vol.12
, pp. 1667-1670
-
-
Soria, J.C.1
Brisgand, D.2
LeChevalier, T.3
-
76
-
-
0035544359
-
The benefits of chemotherapy in patient subgroups with unresectable non-small cell lung cancer
-
Billingham IJ, Cullen MH (2001) The benefits of chemotherapy in patient subgroups with unresectable non-small cell lung cancer. Ann Oncol 12: 1671-1675
-
(2001)
Ann Oncol
, vol.12
, pp. 1671-1675
-
-
Billingham, I.J.1
Cullen, M.H.2
-
77
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR et al. (2000) Phase I Studies of Anti-Epidermal Growth Factor Receptor Chimeric Antibody C225 Alone and in Combination With Cisplatin. J Clin Oncol 18: 904-914
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
-
78
-
-
0001174063
-
Objective regressions in non-small cell lung cancer patients treated in phase I trials of oral ZD 1839 (Iressa) a selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR)
-
abstr 233
-
Kris MG, Herbst R, Rischin D et al. (2000) Objective regressions in non-small cell lung cancer patients treated in Phase I trials of oral ZD 1839 (Iressa) a selective tyrosine kinase inhibitor that blocks the epidermal growth factor receptor (EGFR). Lung Cancer 29 (S1), abstr. 233
-
(2000)
Lung Cancer
, vol.29
, Issue.S1
-
-
Kris, M.G.1
Herbst, R.2
Rischin, D.3
-
79
-
-
0001159137
-
A pilot trial demonstrates the safety of ZDI1839 ("Iressa"), an oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI), in combination with Carboplatin (C) and Paclitaxel (P) in previously untreated advanced Non-small Cell Lung Cancer (NSCLC)
-
abstr 1301
-
Miller VA, Johnson D, Heelan RT et al. (2001) A Pilot Trial Demonstrates the Safety of ZDI1839 ("Iressa"), an Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI), in Combination with Carboplatin (C) and Paclitaxel (P) in Previously Untreated Advanced Non-Small Cell Lung Cancer (NSCLC). Proce ASCO 20, abstr. 1301
-
(2001)
Proce ASCO
, vol.20
-
-
Miller, V.A.1
Johnson, D.2
Heelan, R.T.3
-
80
-
-
0003334692
-
Phase II Eastern Cooperative Oncology Group (ECOG) Pilot Study of Paclitaxel (P), Carboplatin (C), and Trastuzumab (T) in HER-2/neu (+) Advanced Non-Small Cell Lung Cancer (NSCLC): Early Analysis of E2598
-
abstr 1257
-
Langer CJ, Adak S, Thor A et al. (2001) Phase II Eastern Cooperative Oncology Group (ECOG) Pilot Study of Paclitaxel (P), Carboplatin (C), and Trastuzumab (T) in HER-2/neu (+) Advanced Non-Small Cell Lung Cancer (NSCLC): Early Analysis of E2598. Proc ASCO 20, abstr. 1257
-
(2001)
Proc ASCO
, vol.20
-
-
Langer, C.J.1
Adak, S.2
Thor, A.3
-
81
-
-
0001185393
-
Phase III study of the Matrix Metalloprotease (MMP) inhibitor prinomastat in patients having advanced Non-Small Cell Lung Cancer (NSCLC)
-
abstr 1226
-
Smylie M, Mercier R, Aboulafia D et al. (2001) Phase III Study of the Matrix Metalloprotease (MMP) Inhibitor Prinomastat in Patients Having Advanced Non-Small Cell Lung Cancer (NSCLC). Proc ASCO 20, abstr. 1226
-
(2001)
Proc ASCO
, vol.20
-
-
Smylie, M.1
Mercier, R.2
Aboulafia, D.3
-
82
-
-
0003250698
-
Carboplatin (C) + Paclitaxel (T) + RhuMab-VEGF (AVF) May prolong survival in advanced non-squamous lung cancer
-
abstr 256
-
Johnson DH, DeVore R, Kabbinavar F et al. (2001) Carboplatin (C) + Paclitaxel (T) + RhuMab-VEGF (AVF) May Prolong Survival in Advanced Non-Squamous Lung Cancer. Proc ASCO 20, abstr. 256
-
(2001)
Proc ASCO
, vol.20
-
-
Johnson, D.H.1
DeVore, R.2
Kabbinavar, F.3
-
83
-
-
0035868848
-
Adenovirus-mediated wild-typ p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: Results of a multicenter phase II study
-
Schuler M, Hermann R, De Greve JLP et al. (2001) Adenovirus-Mediated Wild-Typ p53 Gene Transfer in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer: Results of a Multicenter Phase II Study. J Clin Oncol 19: 1750-1758.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1750-1758
-
-
Schuler, M.1
Hermann, R.2
De Greve, J.L.P.3
|