Too much of a good thing?

Trends in Endocrinology and Metabolism

Volumn 13, Issue 4, 2002, Pages 139-140

  Bode, Ann M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

AGING; APOPTOSIS; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; DISEASE ASSOCIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENESCENCE; TUMOR SUPPRESSOR GENE; ARTICLE; HUMAN; MUTATION; NEOPLASM; PHYSIOLOGY;

AGING; APOPTOSIS; GENES, P53; HUMANS; MUTATION; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036585012     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00585-4     Document Type: Review

References (15)

1. Levine, A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell 88, 323-331
2. Tyner, S.D. et al. (2002) p53-mutant mice that display early ageing-associated phenotypes. Nature 415, 45-53
3. Itahana, K. et al. (2001) Regulation of cellular senescence by p53. Eur. J. Biochem. 268, 2784-2791
4. Campisi, J. (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, S27-S31
5. Hollstein, M. et al. (1991) p53 mutations in human cancers. Science 253, 49-53
6. Levine, A.J. et al. (1991) The p53 tumour suppressor gene. Nature 351, 453-456
7. Donehower, L.A. et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221
8. Jacks, T. et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol. 4, 1-7
9. Giaccia, A.J. and Kastan, M.B. (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12, 2973-2983
10. Ko, L.J. and Prives, C. (1996) p53: puzzle and paradigm. Genes Dev. 10, 1054-1072
11. Waldman, T. et al. (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res. 55, 5187-5190
12. Bunz, F. et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497-1501
13. Chang, B.D. et al. (2002) Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. U. S. A. 99, 389-394
14. Martin, L.J. (2001) Neuronal cell death in nervous system development, disease, and injury. Int. J. Mol. Med. 7, 455-478
15. Komarov, P.G. et al. (1999) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737