Inhibition of human drug metabolizing cytochrome P450 by buprenorphine

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 5, 2002, Pages 682-685

  Umehara, Ken ^a   Shimokawa, Yoshihiko ^a   Miyamoto, Gohachiro ^a  

^a Tokushima Research Institute   (Japan)

Author keywords

Buprenorphine; Cytochrome P450 inhibition; Human liver microsome; in vitro drug drug interaction

Indexed keywords

BUFURALOL; BUPRENORPHINE; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; ETHOXYRESORUFIN DEETHYLASE; ENZYME INHIBITOR; ISOENZYME; NARCOTIC ANTAGONIST;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; IN VITRO STUDY; KINETICS; METABOLISM;

BUPRENORPHINE; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; ISOENZYMES; KINETICS; MICROSOMES, LIVER; NARCOTIC ANTAGONISTS; SUBSTRATE SPECIFICITY;

EID: 0036581731     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.682     Document Type: Article

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