Regeneration of primary sensory axons into the adult rat spinal cord via a peripheral nerve graft bridging the lumbar dorsal roots to the dorsal column

Journal of Neuroscience Research

Volumn 68, Issue 3, 2002, Pages 293-304

  Dam Hieu, Phong ^a,b   Liu, Song ^a   Choudhri, Tanvir ^c   Said, Gérard ^a   Tadié, Marc ^a  

^a BICÊTRE HOSPITAL   (France)

^b BREST UNIVERSITY HOSPITAL   (France)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Axonal regeneration; Dorsal root ganglia; Horseradish peroxidase; Nerve graft; Sensory axons; Spinal cord injury

Indexed keywords

HORSERADISH PEROXIDASE;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; CONTROLLED STUDY; CORDOTOMY; DEAFFERENTATION; DORSAL ROOT; LUMBAR SPINAL CORD; MALE; MYELIN SHEATH; NERVE FIBER; NERVE FIBER REGENERATION; NERVE GRAFT; NERVE REGENERATION; NEUROFILAMENT; NOCICEPTION; NONHUMAN; PERIPHERAL NERVE; PERONEUS NERVE; PRIORITY JOURNAL; RAT; RETROGRADE NERVE FIBER TRANSPORT; SENSORY DYSFUNCTION; SENSORY NERVE; SPINAL CORD; SPINAL CORD INJURY; STAINING; WHITE MATTER;

AGE FACTORS; ANIMALS; AXONS; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GRAFT SURVIVAL; HORSERADISH PEROXIDASE; LUMBAR VERTEBRAE; MALE; MICROSCOPY, ELECTRON; MOVEMENT DISORDERS; NERVE FIBERS, MYELINATED; NERVE REGENERATION; NEURONS, AFFERENT; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; RHIZOTOMY; SENSATION DISORDERS; SPINAL CORD; SPINAL CORD INJURIES; SPINAL NERVE ROOTS; TISSUE TRANSPLANTATION; TREATMENT OUTCOME;

EID: 0036569644     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10179     Document Type: Article

References (68)

1. PNS grafts used as bridges between the rat CNS and skeletal muscles
2. An improved technique for the microinjection of horseradish peroxidase
3. Median nerve neurotization by peripheral nerve grafts directly implanted into the spinal cord: Anatomical, behavioral and electrophysiological evidences of sensorimotor recovery
4. NT-3 promotes growth of lesioned adult rat sensory neurons ascending in the dorsal columns of the spinal cord
5. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
6. Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependant mechanism
7. Dorsal root innervation of spinal cord neurons after dorsal root implantation into the spinal cord of adult rats
8. Nerve fibre regeneration across the peripheral-central transitional zone
9. Extension of dorsal horn neurons into the severed and implanted dorsal root
10. Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury
11. Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb functions
12. GAP-43 expression in primary sensory neurons following central axotomy
13. Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: The influence of a peripheral nerve graft
14. Axonal regeneration from injured dorsal roots into the spinal cord of adult rats
15. Recherches sur la repousse intra-cordonale de fibres sensitives sectionnées dans la racine postérieure chez le chat
16. Horseradish peroxidase retrograde labeling of primary sensory neurons: A comparison of four intraspinal application methods
17. Regeneration of adult axons in white matter tracts of the central nervous system
18. Attempts to facilitate dorsal column axonal regeneration in a neonatal spinal environment
19. Peripheral nerve autografts to the injured spinal cord of the rat: An experimental model for the study of spinal cord regeneration
20. Central reorganization of the sensory pathways following peripheral nerve regeneration in fetal monkeys
21. The transitional zone and CNS regeneration
22. Experimental microsurgical repair of spinal roots
23. Guidance of regrowing sensory axons after cutaneous nerve lesions in the cat
24. Quantitation of sprouting dorsal root axons
25. Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord: A preliminary report
26. Spontaneous regeneration of the pyramidal tract after transection in young rats
27. Embryonic central nervous system transplants mediate adult dorsal root regeneration into host spinal cord
28. Neurotrophic agents in fibrin glue mediate adult dorsal root regeneration into spinal cord
29. Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site
30. Regeneration of dorsal column axons after spinal cord injury in young rats
31. Collateral reinnervation and expansive regenerative reinnervation by sensory axons into foreign denervated skin: An immunohistochemical study in the rat
32. Peripherally grafted human fetal dorsal root ganglion cell extend axons into the spinal cord of adult hosts rats by circumventing dorsal root entry zone astrocytes
33. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord
34. Repair of adult rat cortico-spinal tract by transplants of olfactory ensheating cells
35. Axonal regrowth through a collagen guidance channel bridging spinal cord to the C6 avulsed roots; functional recovery in primates with brachial plexus injury
36. Reinnervation of denervated lumbar ventral roots and their target muscles by thoracic spinal motoneurons via an implanted nerve in adult rats after spinal cord injury
37. Innervation of the caudal denervated lumbar ventral roots and their target muscles by the rostral spinal motoneurons after implanting a nerve autograft in spinal cord injured adult marmosets
38. Astrocytes block axonal regeneration in mammals by activating the physiological stop pathway
39. Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain
40. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
41. Sprouting of peripherally regenerating primary sensory neurones in the adult central nervous system
42. Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord
43. Tetramethyl benzidine for horseradish peroxidase neurochemistry: A non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents
44. Expansion of spinal cord primary sensory afferent projection following combined sciatic nerve resection and saphenous nerve crush: A horseradish peroxidase study in the adult rat
45. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
46. Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord
47. Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord
48. Regeneration of adult rat sensory axons into intraspinal nerve grafts: Promoting effects of conditioning lesion and graft predegeneration
49. Failure of regenerating dorsal root axons to regrow into the spinal cord
50. Activated macrophage/microglial cells promote the regeneration of sensory axons in the injured spinal cord
51. Functional regeneration of sensory axons into the adult spinal cord
52. Degeneration and regeneration of the sensory nerve ganglia
53. Regeneration into the spinal cord of transected dorsal roots axons is promoted by ensheating glia transplants
54. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cord by olfactory ensheating glia
55. Peripheral injury enhances central regeneration of primary sensory neurons
56. Axonal regeneration in dorsal spinal roots is accelerated by peripheral axonal transection
57. Peripheral nerve autografts to the rat spinal cord: Studies with axonal tracing methods
58. Dorsal root repair by means of autologous nerve graft: Experimental study in the rat
59. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
60. Oligodendrocytes and CNS myelin are non permissive substrates for neurite growth and fibroblast spreading in vitro
61. Degeneration and regeneration of axons in the lesioned spinal cord
62. A comparison of the regeneration potential of dorsal root fibers into gray or white matter of the adult rat spinal cord
63. Regrowth of dorsal root axons into a radiation-induced glial deficient environment in the spinal cord
64. Biology of neurological recovery and functional restoration after spinal cord injury
65. Regeneration of adult dorsal root axons into transplants of embryonic spinal cord
66. Somatosensory system
67. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
68. NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats