Jun: Transcription factor and oncoprotein

Journal of Molecular Medicine

Volumn 74, Issue 12, 1996, Pages 725-747

  Rahmsdorf, Hans J ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Activator protein 1; Glucocorticoid receptor; Proline directed protein kinases; Protein phosphorylation; Stress response

Indexed keywords

HORMONE RECEPTOR; PROTEIN KINASE; TRANSCRIPTION FACTOR;

CARCINOGENESIS; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR CLONING; ONCOGENE C FOS; ONCOGENE C JUN; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029828191     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050077     Document Type: Review

References (281)

1. Abate C, Patel L. Rauscher III FJ. Curran T (1990) Redox regulation of Fos and Jun DNA-binding activity in vitro. Science 249:1157-1161
2. Adler V, Franklin CC, Kraft AS (1992) Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal δ domain. Proc Natl Acad Sci USA 89:5341-5345
3. Adler V, Polotskaya A, Wagner F, Kraft AS (1992) Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267: 17001-17005
4. Adler V, Unlap T, Kraft AS (1994) A peptide encoding the c-Jun δ domain inhibits the activity of a c-Jun ammo-terminal protein kinase. J Biol Chem 269:11186-11191
5. Allison AC (1988) Immunopathogenic mechanisms of arthritis. In: Immunopathogenetic mechanisms of arthritis Goodacre J. Dick WC (eds). MIT Press. Boston, pp 211-245
6. Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ. Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (1987) Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739
7. Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M (1988) Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332:166-171
8. Angel P, Hattori K, Smeal T, Karin M (1988) The jun protooncogene is positively autoregulated by its product. Jun/AP-1. Cell 55:875-885
9. Angel P, Smeal T, Meek J, Karin M (1989) Jun and v-Jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biologist 1:35-43
10. Angel P, Karin M (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129-157
11. Angel P, Herrlich P (ed) (1994) The Fos and Jun families of transcription factors. CRC, Boca Raton
12. Angel P, Herrlich P (1994) General structure of AP-1 subunits and characteristics of the Jun proteins. In: Angel P, Herrlich P (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 3-14
13. Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M (1994) Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226-229
14. Aronin N, Sagar SM, Sharp FR, Schwartz WJ (1990) Light regulates expression of a Fos-relaled protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci USA 87:5959-5962
15. Auer H-P, König H, Litfin M, Stein B, Rahmsdorf HJ (1994) Ultraviolet irradiation, although it activates the transcription factor AP-1 in F9 teratocarcinoma stem cells, does not induce the full complement of differentiation associated genes. Exp Cell Res 213:131-138
16. Auwerx J, Sassone-Corsi P (1991) IP-1: a dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation. Cell 64:983-993
17. Auwerx J, Sassone-Corsi P (1992) AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth. Oncogene 7:2271-2280
18. Baichwal VR, Tjian R (1990) Control of cJun activity by interaction of a cell-specific inhibitor. Cell 63:815-825
19. Baichwal VR, Park A, Tjian R (1992) The cell-type-specific activator region of c-Jun juxtaposes constitutive and negatively regulated domains. Genes Dev 6:1493-1502
20. Baker SJ, Kerppola TK, Luk D, Vandenberg MT, Marshak DR, Curran T, Abate C (1992) Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Mol Cell Biol 12:4694-4705
21. Bannister AJ, Kouzarides T (1995) CBP-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J 14:4758-4762
22. Bannister AJ, Oehler T, Wilhelm D, Angel P, Kouzarides T (1995) Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11:2509-2514
23. Bartel DP, Sheng M, Lau LF, Greenberg ME (1989) Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev 3:304-313
24. Belman S, Troll W (1972) The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones. Cancer Res 32:450-454
25. Benbrook DM, Jones NC (1990) Heterodimer formation between CREB and JUN proteins. Oncogene 5:295-302
26. Bengal E, Ransone L, Scharfmann R, Dwarki VJ, Tapscot SJ, Weintraub H, Verma IM (1992) Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell 68:507-519
27. Berko-Flint Y, Levkowitz G, Vardimon L (1994) Involvement of c-Jun in the control of glucocorticoid receptor transcriptional activity during development of chicken retinal tissue. EMBO J 13:646-654
28. Binétruy B, Smeal T, Karin M (1991) Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351:122-127
29. Black EJ, Catling AD, Woodgett JR, Kilbey A, Gillespie DAF (1994) Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation. Oncogene 9:2363-2368
30. 29a. Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL (1996) Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. J Biol Chem 271:5361-5368
31. Blumer KJ, Johnson GL (1994) Diversity in function and regulation of MAP kinase pathways. Trends Biochem Sci 19:236-240
32. Bohmann D, Tjian R (1989) Biochemical analysis of transcriptional activation by Jun: differential activity of c- and v-Jun. Cell 59:709-717
33. Bohmann D, Bos TJ, Admon A, Nishimura T, Vogt PK, Tjian R (1987) Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238:1386-1392
34. Bohmann D, Ellis MC, Staszewski LM, Mlodzik M (1994) Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78:973-986
35. Bos TJ, Rauscher III FJ, Curran T, Vogt PK (1989) The carboxy terminus of the viral jun oncoprotein is required for complex formation with the cellular fos protein. Oncogene 4:123-126
36. Bos TJ, Monteclaro FS, Mitsunobu F, Ball Jr, AR, Chang CHW, Nishimura T, Vogt PK (1990) Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev 4:1677-1687
37. Bossier P, Fernandes L, Rocha D, Rodrigues-Pousada C (1993) Overexpression of YAP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline. J Biol Chem 268: 23640-23645
38. Boyle WJ, Smeal T, Defize LHK, Angel P, Woodgett JR. Karin M, Hunter T (1991) Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64:573-584
39. Brach MA, Herrmann F, Yamada H, Baeuerle P, Kufe DW (1992) Identification of NF-jun, a novel inducible transcription factor that regulates c-jun gene transcription. EMBO J 11:1479-1486
40. Brach MA, Herrmann F, Kufe DW (1992) Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells. Blood 79:728-734
41. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M (1989) Prolonged activation of jun and collagenase genes by tumour necrosis factor-α. Nature 337:661-663
42. Brenner DA, Koch KS, Leffert HL (1989) Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. DNA 8:279-285
43. Brooks JW, Yoza BK, Mizel SB (1995) Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the level of Jun B protein accumulation. Mol Immunol 32:779-788
44. Bukh A, Martinez-Valdez H, Freedman SJ, Freedman MH, Cohen A (1990) The expression of c-fos, c-jun and c-myc genes is regulated by heat shock in human lymphoid cells. J Immunol 144:4835-4840
45. Cano E, Mahadevan LC (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122
46. Cano E, Hazzalin CA, Mahadevan LC (1994) Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol 14:7352-7362
47. Cano E, Doza YN, Ben-Levy R, Cohen P, Mahadevan LC (1996) Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2. Oncogene 12: 805-812
48. Castellazzi M, Dangy J-P, Mechta F, Hirai S-I, Yaniv M, Samarut J, Lassailly A, Brun G (1990) Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype. Oncogene 5:1541-1547
49. Castellazi M, Spyrou GLV, la Vista N, Dangy J-P, Piu F, Yaniv M, Brun G (1991) Overexpression of c-jun. junB, or junD affects cell growth differently. Proc Natl Acad Sci USA 88: 8890-8894
50. Chae HP, Jarvis LJ, Uckun FM (1993) Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lymphohematopoietic precursor cells. Cancer Res 53:447-451
51. Chaproniere DM, Webber MM (1985) Dexamethasone and retinyl acetate similarly inhibit and stimulate EGF- or insulin-induced proliferation of prostate epithelium. J Cell Physiol 122:249-253
52. Chatton B, Bocco JL, Goetz J, Gaire M, Lutz Y, Kedinger C (1994) Jun and Fos heterodimerize with ATFa. a member of the ATF/CREB family and modulate its transcriptional activity. Oncogene 9:375-385
53. Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M (1988) The c-fos proteininteracts with c-jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54:541-552
54. Chiu R, Angel P, Karin M (1989) Jun-B differs in its biological properties from, and is a negative regulator of J cJun. Cell 59:979-986
55. Chou SY, Baichwal V, Ferrell JE, Jr, (1992) Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. Mol Biol Cell 3:1117-11130
56. Cohen DR, Curran T (1990) Analysis of dimerization and DNA binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region. Oncogene 5:929-939
57. Cohen DR, Ferreira PCP, Gentz R, Franza Jr. BR, Curran T (1989) The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev 3:173-184
58. Cross JC, Wen P, Rutter WJ (1993) Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc Natl Acad Sci USA 90:8078-8082
59. Curran T, Miller AD, Zokas L, Verma IM (1984) Viral and cellular fos proteins: a comparative analysis. Cell 36:259-268
60. Curran T, van Beveren C, Ling N, Verma IM (1985) Viral and cellular fos proteins are complexed with a 39.000-Dalton cellular protein. Mol Cell Biol 5:167-172
61. Dai T, Rubie E, Franklin CC, Kraft A, Gillespie DAF. Avruch J, Kyriakis JM, Woodgett JR (1995) Stress-activated protein kinases bind directly to the δ domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncocene 10:849-855
62. Datta R, Hallahan DE, Kharbanda SM, Rubin E, Sherman ML, Huberman E, Weichselbaum RR, Kufe DW (1992) Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry 31: 8300-8306
63. Davis RJ (1994) MAPKs: new JNK expands the group. Trends Biochem Sci 19:470-473
64. de Groot RP, Kruyt FAE, van der Saag PT, Kruijer W (1990) Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells. EMBO J 9:1831-1837
65. de Groot RP, Schoorlemmer J, van Genesen ST, Kruijer W (1990) Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells. Nucleic Acids Res 18:3195-3202
66. de Groot RP, Foulkes N, Mulder M, Kruiyer W, Sassone-Corsi P (1991) Positive regulation of jun/AP-1 by E1A. Mol Cell Biol 11:192-201
67. de Groot RP, Karperien M, Pals C, Kruijer W (1991) Characterization of the mouse junD promoter- high basal level activity due to an octamer motif. EMBO J 10:2523-2532
68. de Groot RP, Pals C, Kruijer W (1991) Transcriptional control of c-jun by retinoic acid. Nucleic Acids Res 19:1585-1591
69. Deng T, Karin M (1993) JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev 7:479-490
70. Deutsch PJ, Hoeffler JP, Jameson JL, Habener JF (1988) Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci USA 85:7922-7926
71. Dérijard B, Hibi M, Wu I-H, Barrett T, Su B, Deng T, Karin M, Davis RJ (1994) JNKI: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037
72. Dévary Y, Gottlieb RA, Lau LF, Karin M (1991) Rapid and preferential activation of the C-jun gene during the mammalian UV response. Mol Cell Biol 11:2804-2811
73. Dévary Y, Gottlieb RA, Smeal T, Karin M (1992) The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081-1091
74. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272
75. Distel RJ, Ro H-S, Rosen BS, Groves DL, Spiegelman BM (1987) Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell 49:835-844
76. Doucas V, Spyrou G, Yaniv M (1991) Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells. EMBO J 10:2237-2245
77. Estus S, Zaks WJ, Freeman RS, Grudu M, Bravo R, Johnson EM. Jr. (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 127:1717-1727
78. Franklin CC, Sanchez V, Wagner F, Woodgett JR, Kraft AS (1992) Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Proc Natl Acad Sci USA 89:7247-7251
79. Franza Jr, BR, Rauscher III FJ, Josephs SF, Curran T (1988) The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites. Science 239:1150-1153
80. Gaub M-P, Bellard M, Scheuer I, Chambon P, Sassone-Corsi P (1990) Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex. Cell 63:1267-1276
81. Gentz R, Rauscher III FJ, Abate C, Curran T (1989) Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243:1695-1699
82. Ginsberg D, Hirai S-I, Pinhasi-Kimhi O, Yaniv M, Oren M (1991) Transfected mouse c-jun can inhibit transformation of primary rat embryo fibroblasts. Oncogene 6:669-672
83. Glover JNM, Harrison SC (1995) Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373:257-261
84. Goode N, Hughes K, Woodgett JR, Parker PJ (1992) Differential regulation of glycogen synthase kinase-3β by protein kinase C isotypes. J Biol Chem 267:16878-16882
85. Gupta S, Campbell D, Dérijard B, Davis RJ (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389-393
86. Haby C, Aunis D, Zwiller J (1994) Okadaic acid induces activator protein 1 activity and immediate early gene transcription in rat pheochromocytoma cells. Mechanism of action. Biochem Pharmacol 48:819-825
87. Hadman M, Loo M, Bos TJ (1993) In vivo viral and cellular Jun complexes exhibit differential interaction with a number of in vitro generated 'AP-1- and CREB-like' target sequences. Oncogene 8:1895-1903
88. Hagmeyer BM, König H, Herr I, Offringa R, Zantema A, van der Eb AJ, Herrlich P, Angel P (1993) Adenovirus F1A negatively and positively modulates transcription of AP-1 dependent genes by dimer-specific regulation of the DNA binding and transactivation activities of Jun. EMBO J 12:3559-3572
89. Hai T, Curran T (1991) Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88:3720-3724
90. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P (1988) c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55:917-924
91. Hallahan DE, Sukhatme VP, Sherman ML, Virudachalam S, Kufe D, Weichselbaum RR (1991) Protein kinase C mediates X-ray inducibility of nuclear signal transducers EGR1 and JUN Proc Natl Acad Sci USA 88:2156-2160
92. Hallahan DE, Virudachalam S, Schwartz JL, Panje N, Mustafi R, Weichselbaum RR (1992) Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation. Radiat Res 129:345-350
93. Hallahan DE, Gius D, Kuchibhotla J, Sukhatme V, Kufe DW, Weichselbaum RR (1993) Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem 268:4903-4907
94. Hallahan DE, Bleakman D, Virudachalam S, Lee D, Grdina D, Kufe DW, Weichselbaum RR (1994) The role of intracellular calcium in the cellular response to ionizing radiation. Radiat Res 138:392-400
95. Hamil KG, Conti M, Shimasaki S, Hall SH (1994) Follicle-stimulating hormone regulation of AP-1: inhibition of c-jun and stimulation of jun-R gene transcription in the rat Sertoli cell. Mol Cell Endocrinol 99:269-277
96. Man T-H, Lamph WW, Prywes R (1992) Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter. Mol Cell Biol 12:4472-4477
97. Han J, Lee J-D, Bibbs L, Ulevitch RJ (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811
98. Harshman KD, Moye-Rowley WS, Parker CS (1988) Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4. Cell 53:321-330
99. Hattori K, Angel P, Le Beau MM, Karin M (1988) Structure and chromosomal localization of the functional intronless human jun protooncogenc. Proc Natl Acad Sci USA 85:9148-9152
100. Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, Cato ACB (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13:4087-4095
101. Herr I, van Dam H, Angel P (1994) Binding of promoter associated AP-1 is not altered during induction and subsequent repression of the c-jun promoter by TPA and UV irradiation. Carcinogenesis 15:1105-1113
102. Herrera RE, Shaw PE, Nordheim A (1989) Occupation of the C-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction. Nature 340:68-70
103. Hibi M, Lin A, Smeal T, Minden A, Karin M (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7:2135-2148
104. Hilberg F, Wagner EF (1992) Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity. Oncogene 7:2371-2380
105. Hilberg F, Aguzzi A, Howells N, Wagner EF (1993) c-Jun is essential for normal mouse development and hepatogenesis Nature 365:179-181
106. Hirai S-I, Ryseck R-P, Mechta F, Bravo R, Yaniv M (1989) Characterization of junD: a new member of the jun protooncogene family. EMBO J 8:1433-1439
107. Hope IA, Struhl K (1986) Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46:885-894
108. Hope IA, Struhl K (1987) GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J 6:2781-2784
109. Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632-634
110. Hunter T, Sefton BM (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci USA 77:1311-1315
111. Huo L, Rothstein TL (1995) Receptor-specific induction of individual AP-1 components in B lymphocytes. J of Immunol 154:3300-3309
112. Imaki J, Yamashita K, Yamakawa A, Yoshida K (1995) Expression of jun family genes in rat retinal cells: regulation by light/dark cycle. Brain Res Mol Brain Res 30:48-52
113. Ivashkiv LB, Liou H-C, Kara CJ, Lamph WW, Verma IM, Glimcher LH (1990) mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element. Mol Cell Biol 10:1609-1621
114. Jaaskelainen T, Pirskanen A, Ryhanen S, Palvimo JJ. Deluca HF, Maenpaa PH (1994) Functional interference between AP-1 and the vitamin D receptor on osteocalcin gene expression in human osteosarcoma cells. Eur J Biochem 224:11-20
115. Janssen YMW, Heintz NH, Mossman BT (1995) Induction of c-fos and c-jun proto-oncogene expression by asbestos is ameliorated by N-acetyl-L-cysteine in mesothelial cells. Cancer Res 55:2085-2089
116. Johnson RS, van Lingen B, Papaioannou VE, Spiegelman BM (1993) A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev 7:1309-1317
117. Jonat C, Rahmsdorf HJ, Park K-K, Cato ACB, Gebel S, Ponta H, Herrlich P (1990) Anti-tumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204
118. Kamada S, Toyoshima K, Akiyama T (1994) Serum-independent phophorylation of c-Jun and alterations in AP-1 components by transformation with various oncogenes. J Biol Chem 269:4565-4570
119. Karin M (1995) The regulation of AP-1 activity by mitogenactivated protein kinases. J Biol Chem 270:16483-16486
120. Kerppola TK, Curran T (1991) Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 66:317-326
121. Kerppola TK, Curran T (1991) DNA bending by Fos and Jun: the flexible hinge model. Science 254:1210-1214
122. Kimura E, Sonobe MH, Armelin MC, Armelin HA (1993) Induction of FOS and JUN proteins by adrenocorticotropin and phorbol ester but not by 3′.5′-cyclic adenosine monophosphate derivatives. Mol Endocrinol 7:1463-1471
123. Kitabayashi I, Saka F, Gachelin G, Yokoyama K (1990) Nucleotide sequence of rat c-jun protooncogene. Nucleic Acids Res 18:3400
124. Kitabayashi I, Chiu R, Gachelin G, Yokoyama K (1991) E1A dependent up-regulation of c-jun/AP-1 activity. Nucleic Acids Res 19:649-655
125. Kitabayashi I, Kawakami Z, Chiu R, Ozawa K, Matsuoka T, Toyoshima S, Umesono K, Evans RM, Gachelin G, Yokoyama K (1992) Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. EMBO J 11:167-175
126. Kitabayashi I, Kawakami Z, Matsuoka T, Chiu R, Gachelin G, Yokoyama K (1993) Two cis-regulatory elements that mediate different signaling pathways for serum-dependent activation of the junB gene. J Biol Chem 268:14482-14489
127. König H, Ponta H, Rahmsdorf HJ, Herrlich P (1992) Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-I site occupation vivo. EMBO J 11: 2241-2246
128. Kornhauser JM, Nelson DE, Mayo KE, Tukahashi JS (1992) Regulation of jun-B messenger RNA and AP-1 activity by light and circadian clock. Science 255:1581-1584
129. Kouzarides T, Ziff E (1988) The role of the leucine zipper in the fos-jun interaction. Nature 336:646-651
130. Kovary K, Bravo R (1991) Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations. Mol Cell Biol 11:2451-2459
131. Kryszke M-H, Piette J, Yaniv M (1987) Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells. Nature 328:254-256
132. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR (1994) The stress-activated protein kinase subfamily of cJun kinases. Nature 369:156-160
133. Kwok RPS, Lundblad JR, Chrivia JC, Richards JP, Bächinger HP, Brennan RG, Roberts SGE, Green MR, Goodman RH (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223-226
134. Lamph WW, Wamsley P, Sassone-Corsi P, Verma IM (1988) Induction of proto-oncogene Jun/AP-1 by serum and TPA. Nature 334:629-631
135. Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764
136. Landschulz WH, Johnson PF, McKnight SL (1989) The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243:1681-1688
137. Ledwith BJ, Manam S, Troilo P, Joslyn DJ, Galloway SM, Nichols WW (1993) Activation of immediate-early gene expression by peroxisome proliferators in vivo. Mol Carc. 8:20-27
138. Lee W, Mitchell P, Tjian R (1987) Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49:741-752
139. Li L, Chambard J-C, Karin M, Olson E (1992) Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes Dev 6:676-689
140. Lin A, Frost J, Deng T, Smeal T, Al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M (1992) Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70:777-789
141. Lin A, Minden A, Martinetto H, Claret F-X, Lange-Carter C, Mercurio F, Johnson GL, Karin M (1995) Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290
142. Liu J, Nickolenko J, Sharp FR (1994) Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. Proc Natl Acad Sci USA 91:8537-8541
143. Livingstone C, Patel G, Jones N (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 14:1785-1797
144. Lu B, Rothnagel JA, Longley MA, Tsai SY, Roop DR (1994) Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. J Biol Chem 269:7443-7449
145. Lucibello FC, Slater EP, Jooss KU, Beato M, Müller R (1990) Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB. EMBO J 9:2827-2834
146. MacGregor PF, Abate C, Curran T (1990) Direct cloning of leucine zipper proteins: Jun binds cooperatively to the CRE with CRE-BP1. Oncogene 5:451-458
147. Maki Y, Bos TJ, Davis C, Starbuck M, Vogt PK (1987) Avian sarcoma virus 17 carries the jun oncogene. Proc Natl Acad Sci USA 84:2848-2852
148. Mayo MW, Steelman LS, McCubrey JA (1994) Phorbol esters support the proliferation of a hematopoietic cell line by upregulating c-jun expression. Oncogene 9:1999-2008
149. Mechta F, Yaniv M (1994) Structure and regulation of the c-jun promoter. In: Angel P, Herrlieh P (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 115-129
150. Mechta F, Pielte J, Hirai S-I, Yaniv M (1989) Stimulation of protein kinase C or protein kinase A mediated signal transduction pathways shows three modes of response among serum inducible genes. New Biologist 1:297-304
151. Menegazzi M, Carcereri De Prati AC, Zucconi GG (1994) Differential expression pattern of jun B and c-jun in the rat brain during the 24-h cycle. Neurosci Lett 182:295-298
152. Meyer M, Schreck R, Baeuerle PA (1993) H2O2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J 12:2005-2015
153. Miner JN, Yamamoto KR (1992) The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element. Genes Dev 6:2491-2501
154. Mollinedo F, Gajate C, Tugores A, Flores I, Naranjo JR (1993) Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. Biochem J 294: 137-144
155. Monteclaro FS, Vogt PK (1993) A Jun-binding protein related to a putative tumor suppressor. Proc Natl Acad Sci USA 90:6726-6730
156. Mordacq JC, Linzer DIH (1989) Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes Dev 3:760-769
157. Morgan JI, Curran T (1991) Stimulus-transcription coupling in the nervous system: Involvement of the inducible protooncogenes fos and jun. Ann Rev Neurosci 14:421-451
158. Morooka H, Bonventre JV, Pombo CM, Kyriakis JM, Force T (1995) Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter. J Biol Chem 270:30084-30092
159. Moye-Rowley WS, Harshman KD, Parker CS (1989) Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev 3:283-292
160. Muegge K, Vila M, Gusella GL, Musso T, Herrlich P, Stein B, Durum SK (1993) Interleukin 1 induction of the c-jun promoter. Proc Natl Acad Sci USA 90:7054-7058
161. Nakabeppu Y, Nathans D (1989) The basic region of Fos mediates specific DNA binding. EMBO J 8:3833-3841
162. Nakabeppu Y, Ryder K, Nathans D (1988) DNA binding activities of three murine jun proteins: stimulation by fos. Cell 55:907-915
163. Naranjo JR, Mellström B, Sassone-Corsi P (1994) Fos/Jun in brain function. In: Angel P, Herrlich P (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 151-161
164. Natoli G, Avantaggiati ML, Chirillo P, Puri PL, Ianni A, Balsano C, Levrero M (1994) Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX. Oncogene 9:2837-2843
165. Natoli G, Avantaggiati ML, Chirillo P, Costanzo A, Artini M, Balsano C, Levrero M (1994) Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus activator pX. Mol Cell Biol 14:989-998
166. Nephew KP, Polek TC, Akcali KC, Khan SA (1993) The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus. Endocrinol 133:419-422
167. Neuberg M, Schuermann M, Hunter JB, Müller R (1989) Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex. Nature 338:589-590
168. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P (1990) Negative regulation of the rat strome-lysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J 9:4443-4454
169. Nikolakaki E, Coffer PJ, Hemelsoet R, Woodgett JR, Defize LHK (1993) Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8:833-840
170. Nishimura T, Vogt PK (1988) The avian cellular homolog of the oncogene jun. Oncogene 3:659-663
171. Nose K, Shibanuma M, Kikuchi K, Kageyama H, Sakiyama S, Kuroki T (1991) Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem 201:99-106
172. Oehler T, Angel P (1992) A common intermediary factor (p52/54) recognizing "acidic-blob"-type domains is required for transcriptional activation by the Jun proteins. Mol Cell Biol 12:3508-5515
173. Oehler T, Pintzas A, Stumm S, Darling A, Gillespie D, Angel P (1993) Mutation of a phosphorylation site in the DNA-binding domain is required for redox-independent transactivation of AP1-dependent genes by v-Jun. Oncogene 8:1141-1147
174. Oliviero S, Robinson GS, Struhl K, Spiegelman BM (1991) Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation. Genes Dev 6: 1799-1809
175. O'Shea EK, Rutkowski R, Kim PS (1989) Evidence that the leucine zipper is a coiled coil. Science 243:538-542
176. O'Shea EK, Rutkowski R, Stafford III WF, Kim PS (1989) Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science 245:646-648
177. Papavassiliou AG, Chavrier C, Bohmann D (1992) Phosphorylation state and DNA-binding activity of cJun depend on the intracellular concentration of binding sites. Proc Natl Acad Sci USA 89:11562-11565
178. Papavassiliou AG, Treier M, Chavrier C, Bohmann D (1992) Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun. Science 258:1941-1944
179. Papavassiliou AG, Treier M, Bohmann D (1995) Intramolecular signal transduction in c-Jun. EMBO J 14:2014-2019
180. Pazmany T, Murphy SP, Gollnick SO, Brooks SP, Tomasi TB (1995) Activation of multiple transcription factors and fos and jun gene family expression in cells exposed to a single electric pulse. Exp Cell Res 221:103-110
181. Pearce D, Yamamoto KR (1993) Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element. Science 259:1161-1165
182. Perez-Albuerne ED, Schatteman G, Sanders LK, Nathans D (1993) Transcriptional regulatory elements downstream of the JunB gene. Proc Natl Acad Sci USA 90:11960-11964
183. Perkins KK, Dailey GM. Tjian R (1988) Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1. EMBO J 7:4265-4273
184. Pertovaara L, Sistonen L, Bos TJ, Vogt PK, Keski-Oja J, Alitalo K (1989) Enhanced Jun gene expression is an early genomic response to transforming growth factor β Stimulation. Mol Cell Biol 9:1255-1262
185. Pestell RG, Hollenberg AN, Albanese C, Jameson JL (1994) c-Jun represses transcription of the human chorionic gonadotropin α and β genes through distinct types of CREs. J Biol Chem 269:31090-31096
186. Petrak D, Memon SA, Birrer MJ, Ashwell JD, Zacharchuk CM (1994) Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription. J Immunol 153:2046-2051
187. Pfarr CM, Mechta F, Spyrou G, Eallemand D, Carillo S, Yaniv M (1994) Mouse Jun-D negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76: 747-760
188. Phinney DG, Keiper CL, Francis MK, Ryder K (1994) Quantitative analysis of the contribution made by 5′-flanking and 3′-flanking sequences to the transcriptional regulation of JunB by growth factors. Oncogene 9:2353-2362
189. Piette J, Yaniv M (1987) Two different factors bind to the α-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers. EMBO J 6:1331-1337
190. Pirson I, Dumont JE (1994) Jun B expression is regulated differently by three mitogenic pathways in thyrocytes. Exp Cell Res 214:561-569
191. Porte D, Oertel-Buchheit P, Granger-Schnarr M, Schnarr M (1995) Fos leucine zipper variants with increased association capacity. J Biol Chem 270:22721-22730
192. Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR (1991) Phosphorylation of c-jun mediated by MAP kinases. Nature 353:670-674
193. Pulverer BJ, Hughes K, Franklin CC, Kraft AS, Leevers SJ, Woodgett JR (1993) Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells. Oncogene 8:407-415
194. Quantin B, Breathnach R (1988) Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts. Nature 334:538-539
195. Radler-Pohl A, Sachsenmaier C, Gebel S, Auer H-P, Bruder JT, Rapp U, Angel P, Rahmsdorf HJ, Herrlich P (1993) UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J 12:1005-1012
196. 194a. Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16:1247-1255
197. Rauscher III FJ, Cohen DR, Curran T, Bos TJ, Vogt PK, Bohmann D, Tjian R, Franza Jr. BR (1988) Fos-associated protein p39 is the product of the jun proto-oncogene. Science 240:1010-1016
198. Rauscher III FJ, Sambucetti LC, Curran T, Distel RJ, Spiegelman BM (1988) Common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 52:471-480
199. Reuse S, Pirson I, Dumont JE (1991) Differential regulation of protooncogenes c-jun and jun D expressions by protein tyrosine kinase, protein kinase C, and cyclic-AMP mitogenic pathways in dog primary thyrocytes: TSH and cyclic-AMP induce proliferation but downregulate c-jun expression. Exp Cell Res 196:210-215
200. Riabowol KT, Schiff J, Gilman MZ (1992) Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc Natl Acad Sci USA 89:157-161
201. Risse G, Jooss K, Neuberg M, Brüller H-J, Müller R (1989) Asymmetrical recognition of the palindromic AP-1 binding site (TRE) by Fos protein complexes. EMBO J 8:3825-3832
202. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027-1037
203. Rozek D, Pfeifer GP (1993) In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response. Mol Cell Biol 13:5490-5499
204. Rubin E, Kharbanda S, Gunji H, Weichselbaum R, Kufe D (1992) cis-Diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res 52:878-882
205. Ryder K, Lau LF, Nathans D (1988) A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci USA 85:1487-1491
206. Ryder K, Lanahan A, Perez-Albuerne E, Nathans D (1989) Jun-D: a third member of the Jun gene family. Proc Natl Acad Sci USA 86:1500-1503
207. Ryseck R-P, Hirai SI, Yaniv M, Bravo R (1988) Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature 334:535-537
208. Ryseck R-P, Bravo R (1991) cJun, JunB and JunD differ in their binding affinities to AP-1 and CRE consensus sequences: effect of Fos proteins. Oncogene 6:553-542
209. Sachsenmaier C, Radler-Pohl A (1994) Regulation of c-Jun activity by phosphorylation. In: Angel P, Herrlich P (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 61-70
210. 207a. Sachsenmaier C, Radler-Pohl A, Zinek R, Nordheim A, Herrlich P, Rahmsdorf HJ (1994) Involvement of growth factor receptors in the mammalian UVC response. Cell 78:963-972
211. Sakai DD, Helms S, Carlstedt-Duke J, Gustafsson J-Å, Rottman FM, Yamamoto KR (1988) Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev 2:1144-1154
212. Sassone-Corsi P, Lamph WW, Kamps M, Vernia IM (1988) fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell 54:553-560
213. Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodaett JR, Avruch J, Kyriakis JM, Zon LI (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372:794-798
214. Schenk H, Klein M, Erdbrügger W, Dröge W, Schulze-Osthoff K (1994) Distinct effects of thioredoxin and antioxidants on the activation of transcription factor NF-κB and AP-1. Proc Natl Acad Sci USA 91:1672-1676
215. Schmitt M, Bausero P, Simoni P, Queuche D, Geoffroy V, Marschal C, Kempf J, Quirin-Stricker C (1995) Positive and negative effects of nuclear receptors on transcription activation by AP-1 of the human choline acetyltransferase proximal promoter. J Neurosci Res 40:152-164
216. Schönthal A, Herrlich P, Rahmsdorf HJ, Ponta H (1988) Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54:325-334
217. Schönthal A, Feramisco JR (1990) Different promoter elements are required for the induced expression of c-fos and c-jun proto-oncogenes by the v-mos oncogene product. New Biologist 2:143-150
218. Schönthal A, Alberts AS, Frost JA, Feramisco JR (1991) Differential regulation of jun family gene expression by the tumor promoter okadaic acid. New Biologist 3:977-986
219. 2+-ATPase inhibitor thapsigargin. Proc Natl Acad Sci USA 88:7096-7100
220. Schönthal A, Srinivas S, Eckhart W (1992) Induction of c-jun protooncogene expression and transcription factor AP-1 activity by the polyoma virus middle-sized tumor antigen. Proc Natl Acad Sci USA 89:4972-1976
221. Schuermann M (1994) The Fos family: gene and protein structure, homologies, and differences. In: Angel P, Herrlich P (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 15-35
222. Schuermann M, Neuberg M, Hunter JB, Jenuwein T, Ryseck R-P, Bravo R, Müller R (1989) The leucine repeat motif in fos protein mediates complex formation with Jun/AP-1 and is required for transformation. Cell 56:507-516
223. Schuermann M, Hunter JB, Hennig G, Müller R (1991) Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization. Nucleic Acids Res 19:739-746
224. Schuh AC, Keating SJ, Monteclaro FS, Vogt PK, Breitman ML (1990) Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice. Nature 346:756-757
225. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans RM (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62:1217-1226
226. Schüle R, Umesono K, Mangelsdorf DJ, Bolado J, Pike JW, Evans RM (1990) Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell 61:497-504
227. Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (1989) Jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell 59:987-997
228. Schütte J, Minna JD, Birrer MJ (1989) Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single gene. Proc Natl Acad Sci USA 86:2257-2261
229. Scribner JD, Slaga TJ (1973) Multiple effects of dexamethasone on protein synthesis and hyperplasia caused by a tumor promoter. Cancer Res 33:542-546
230. Shemshedini L, Knauthe R, Sassone-Corsi P, Portion A, Gronemeyer H (1991) Cell-specific inhibitory effects of Fos and Jun on transcription activation by nuclear receptors. EMBO J 10:3839-3849
231. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW (1990) Ionizing radiation regulates expression of the c-jun protooncogene. Proc Natl Acad Sci USA 87:5663-5666
232. Sistonen L, Hölttö E, Mäkelä TP, Keski-Oja J, Alitalo K (1989) The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression. EMBO J 8:815-822
233. 229a. Sitlani A, Crothers, DM (1996) Fos and Jun do not bend the AP-1 recognition site. Proc Natl Acad Sci USA 93:3248-3252
234. Smeal T, Angel P, Meek J, Karin M (1989) Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev 3:2091-2100
235. Smeal T, Binétruy B, Mercola DA, Birrer M, Karin M (1991) Oncogenic and transcriptional cooperation with Haras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354:494-496
236. Smeal T, Binétruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M (1992) Oncoprotein mediated signalling cascade stimulates cJun activity by phosphorylation of serines 63 and 73. Mol Cell Biol 12:3507-3513
237. Smeal T, Hibi M, Karin M (1994) Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. EMBO J 13:6006-6010
238. Sonnenberg JL, MacGregor-Leon PF, Curran T, Morgan JI (1989) Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 3:359-365
239. Stein B, Angel P, van Dam H, Ponta H, Herrlich P, van der Eb A, Rahmsdorf HJ (1992) Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response. Photochem Photobiol 55:409-415
240. Stein B, Baldwin AS, Ballard DW, Greene WC, Angel P, Herrlich P (1993) Cross-coupling of the NF-κBp65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 12:3879-3891
241. Struhl K (1987) The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell 50:841-846
242. Su H, Bos TJ, Monteclaro FS, Vogt PK (1991) Jun inhibits myogenic differentiation. Oncogene 6:1759-1766
243. Sutherland JA, Cook A, Bannister AJ, Kouzarides T (1992) Conserved motifs in Fos and Jun define a new class of activation domain. Genes Dev 6:1810-1819
244. Suzuki T, Okuno H, Yoshida T, Endo T, Nishina H, Iba H (1991) Difference in transcriptional regulatory function between c-Fos and Fra-2. Nucleic Acids Res 19:5537-5542
245. Taketani Y, Oka T (1983) Possible physiological role of epidermal growth factor in the development of the mouse mammary gland during pregnancy. FEBS Lett 152:256-260
246. Tanguay DA, Dickinson JA, McManus BJ, Huo L, Rothstein TE, Chiles TC (1994) Activation of AP-1 in primary B lymphocytes by surface immunoglobulin requires de novo Jun-B synthesis. Cell Immunol 158:281-291
247. Teurich S, Angel P (1995) The glncocorticoid receptor synergizes with Jun homodimers to activate AP-1-regulated promoters lacking GR binding sites. Chem Senses 20:251-255
248. Tischmeyer W, Grimm R, Schicknick H, Brysch W, Schlingensiepen KH (1994) Sequence-specific impairment of learning by c-jun antisense oligonucleotides. Neuroreport 5:1501-1504
249. Tonelli QJ, Sorof S (1980) Epidermal growth factor requirement for development of cultured mammary gland. Nature 285:250-252
250. 245a. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Current Opinion Cell Biology 8:205-215
251. Trejo J, Chambard J-C, Karin M, Brown JH (1992) Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol 12:4742-4750
252. Turner R, Tjian R (1989) Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 243:1689-1694
253. Unlap T, Franklin CC, Wagner F, Kraft AS (1992) Upstream regions of the c-jun promoter regulate phorbol ester-induced transcription in U937 leukemic cells. Nucleic Acids Res 20:897-902
254. van Dam H, Offringa R, Meijer I, Stein B, Smits AM, Herrlich P, Bos JL, van der Eb AJ (1990) Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family. Mol Cell Biol 10:5857-5864
255. van Dam H, Duyndam M, Rottier R, Bosch A, de Vries-Smits L, Herrlich P, Zantema A, Angel P, van der Eb AJ (1993) Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J 12:479-487
256. van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P, Angel P (1995) ATF-2 is preferentially activated by stress-acitvated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 14:1798-1811
257. Vogt PK (1994) Oncogenic transformation by Jun. In: Angel PE, Herrlich PA (ed) The Fos and Jun families of transcription factors. CRC, Boca Raton, pp 203-219
258. Vogt PK, Bos TJ (1990) Jun: Oncogene and transcription factor. Adv Cancer Res 55:1-35
259. Vogt PK, Bos TJ, Doolittle RF (1987) Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun. Proc Natl Acad Sci USA 84:3316-3319
260. Vrdoljak E, Borchardt PE, Bill CA, Stephens LC, Tofilon PJ (1994) Influence of X-rays on early response gene expression in rat astrocytes and brain tumour cell lines. Int J Radial Biol 66:739-746
261. Webb DK, Moulton BC, Khan SA (1993) Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells. Endocrinol 133:20-28
262. Webster KA, Discher DJ, Bishopric NH (1993) Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem 268:16852-16858
263. Wilson RE, Taylor SL, Atherton GT, Johnston D, Waters CM, Norton JD (1993) Early response gene signalling cascades activated by ionising radiation in primary human B cells. Oncogene 8:3229-3237
264. Wollnik F, Brysch W, Uhlmann E, Gillardon F, Bravo R, Zimmermann M, Schlingensiepen KH, Herdegen T (1995) Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced phase shifts of the mammalian circadian clock. Eur J Neurosci 7:388-393
265. Woost PG, Brightwell J, Eiferman RA, Schultz GS (1985) Effect of growth factors with dexamethasone in healing of rabbit corneal stromal incisions. Exp Eye Res 40:47-60
266. Wu B-y, Fodor EJ, Edwards RH, Rutter WJ (1989) Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. J Biol Chem 264:9000-9003
267. Wu A, Wemmie JA, Edgington NP, Goebl M, Guevara JL, Moye-Rowley WS (1993) Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem 268:18850-18858
268. Xanthoudakis S, Curran T (1992) Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J 11:653-665
269. Xanthoudakis S, Miao G, Wang F, Pan Y-CE, Curran T (1992) Redox-activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 11:3323-3335
270. Xanthoudakis S, Miao GG, Curran T (1994) The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci USA 91:23-27
271. Xie W, Herschman HR (1995) v-src induces prostaglandin synthase 2 gene expression by activation of the c-jun N-terminal kinase and the c-jun transcription factor. J Biol Chem 270:27622-27628
272. Yamaguchi-Iwai Y, Satake M, Murakami Y, Sakai M, Muramatsu M, Ito Y (1990) Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes. Proc Natl Acad Sci USA 87:8670-8674
273. Yang-Yen H-F, Chambard J-C, Sun Y-L, Smeal T, Schmidt TJ, Drouin J, Karin M (1990) Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215
274. Yang-Yen H-F, Chiu R, Karin M (1990) Elevation of AP-1 activity during F9 cell differentiation is due to increased c-jun transcription. New Biologist 2:351-361
275. Yoon JK, Lau LF (1994) Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC 12 cells. Mol Cell Biol 14:7731-7743
276. Yoshioka K, Deng T, Cavigelli M, Karin M (1995) Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc Natl Acad Sci USA 92:4972-4976
277. Zerial M, Toschi L, Ryseck R-P, Schuermann M, Müller R, Bravo R (1989) The product of a novel growth factor activated gene, fos B, interacts with Jun proteins enhancing their DNA binding activity. EMBO J 8:805-813
278. Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N (1990) Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci USA 87:6281-6285
279. Zhang X-K, Dong J-M, Chiu J-F (1991) Regulation of α-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site. J Biol Chem 266:8248-8254
280. Zoeller RT, Fletcher DL (1994) A single administration of ethanol simultaneously increases c-fos mRNA and reduces c-jun mRNA in the hypothalamus and hippocampus. Brain Res Mol Brain Res 24:185-191
281. Zwiller J, Sassone-Corsi P, Kakazu K, Boynton AL (1991) Inhibition of PDGF-induced c-jun and c-fos expression by a tyrosine protein kinase inhibitor. Oncogene 6:219-221