Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats

Journal of Hypertension

Volumn 20, Issue 5, 2002, Pages 909-918

  Gohlke, Peter ^a   Von Kügelgen, Sebastian ^a   Jürgensen, Thomas ^a   Kox, Thomas ^a   Rascher, Wolfgang ^a   Culman, Juraj ^a   Unger, Thomas ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Angiotensin II; Angiotensin II type I receptor antagonist; Candesartan; Central nervous system; Vasopressin

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CANDESARTAN HEXETIL; VASOPRESSIN;

ANIMAL EXPERIMENT; ARTICLE; CHRONOPHARMACOLOGY; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRINKING; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; MALE; MICROINJECTION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS; VASOPRESSIN BLOOD LEVEL; VASOPRESSIN RELEASE;

EID: 0036562926     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200205000-00026     Document Type: Article

References (34)

1. Brain angiotensin: Pathways and pharmacology
2. Brain and pituitary angiotensin
3. Angiotensin II in central nervous system physiology
4. Central antihypertensive effects of inhibitors of the renin-angiotensin system in rats
5. Neurohumoral contributions to chronic angiotensin-induced hypertension
6. Differential effects of central angiotensin II and substance P on sympathetic nerve activity in conscious rats
7. Lowering of hypertension by central saralasin in the absence of plasma renin
8. Brain converting enzyme inhibition: A possible mechanism for the antihypertensive action of captopril in spontaneously hypertensive rats
9. The effects of central administration of angiotensin II type-1 receptor antagonist, CV-22974, in nephrectomized spontaneously hypertensive rats
10. Altered vascular reactivity and baroreflex sensitivity induced by chronic central administration of captopril in spontaneously hypertensive rats
11. 1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hyper-tensive rats reduces hypertension of neurogenic origin
12. 1-R mRNA antisense
13. 1 receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats
14. Access of peripherally administered DuP 753 to rat brain angiotensin receptors
15. Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood- brain barrier
16. Functional evidence that the angiotensin antagonist losartan crosses the blood-brain barrier in the rat
17. 1 receptor antagonists to cross the blood-brain barrier in rats
18. Evaluation of the ability of irbesartan to cross the blood-brain barrier following acute intragastric treatment
19. Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats
20. Chronic peripheral administration of the angiotensin II AT(1) receptor antagonist candesartan blocks brain AT(1) receptors
21. Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release
22. Vasopressin in the plasma of stroke-prone spontaneously hypertensive rats
23. Repeated measurements and multiple comparisons in cardiovascular research
24. 1 receptors on the recovery from focal cerebral ischemia in normotensive rats
25. 1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats
26. Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats
27. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats
28. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent
29. Cardiac and vascular effects of long-term losartan treatment in stroke-prone spontaneously hypertensive rats
30. A review on telmisartan: A novel, long-acting angiotensin II-receptor antagonist
31. 1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats
32. 1-receptor blockers in isolated vessels of different origin
33. 1 receptors
34. 1 receptor antagonists: The role of tight antagonist binding