Serum levels of soluble transferrin receptor correlate with severity of disease but not with iron stores in patients with malignant lymphomas

Tumor Biology

Volumn 23, Issue 3, 2002, Pages 146-153

  Bjerner, Johan ^a   Amlie, Lise Marit ^a   Rusten, Leiv Sindre ^a   Jakobsen, Erling ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Anemia; Chronic disease; Inflammation; Iron deficiency; Lymphoma; Serum; Soluble transferrin receptor

Indexed keywords

LACTATE DEHYDROGENASE; SOLUBLE TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR; BIOLOGICAL MARKER; IRON;

ADULT; ANEMIA; ARTICLE; BLOOD LEVEL; BONE MARROW BIOPSY; CHRONIC DISEASE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DISEASE SEVERITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HUMAN; IRON DEFICIENCY ANEMIA; IRON STORAGE; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; SMEAR; BLOOD; BONE MARROW; CHEMISTRY;

ADULT; ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; BONE MARROW; HODGKIN DISEASE; HUMANS; IRON; LYMPHOMA; LYMPHOMA, NON-HODGKIN; MALE; RECEPTORS, TRANSFERRIN;

EID: 0036559782     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064031     Document Type: Article

References (45)

1. Kohgo Y, Niitsu Y, Kondo H, Kato J, Tsushima N, Sasaki K, Hirayama M, Numata T, Nishisato T, Urushizaki I: Serum transferrin receptor as a new index of erythropoiesis. Blood 1987;70:1955-1958.
2. Feelders RA, Kuiper-Kramer EP, van Eijk HG: Structure, function and clinical significance of transferrin receptors. Clin Chem Lab Med 1999;37:1-10.
3. Flowers CH, Skikne BS, Covell AM, Cook JD: The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989;114:368-377.
4. Huebers HA, Finch CA: The physiology of transferrin and transferrin receptors. Physiol Rev 1987;67:520-582.
5. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA: Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990;75:102-107.
6. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD: Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990;265:19077-19081.
7. Baynes RD, Shih YJ, Hudson BG, Cook JD: Production of the serum form of the transferrin receptor by a cell membrane-associated serine protease. Proc Soc Exp Biol Med 1993;204:65-69.
8. Suominen P, Punnonen K, Rajamaki A, Irjala K: Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency in anemic patients. Clin Chem 1997;43:1641-1646.
9. Allen J, Backstrom KR, Cooper JA, Cooper MC, Detwiler TC, Essex DW, Fritz RP, Means RT Jr, Meier PB, Pearlman SR, Roitman-Johnson B, Seligman PA: Measurement of soluble transferrin receptor in serum of healthy adults. Clin Chem 1998;44:35-39.
10. Vernet M, Doyen C: Assessment of iron status with a new fully automated assay for transferrin receptor in human serum. Clin Chem Lab Med 2000;38:437-442.
11. Raya G, Henny J, Steinmetz J, Herbeth B, Siest G: Soluble transferrin receptor (sTfR): Biological variations and reference limits. Clin Chem Lab Med 2001;39:1162-1168.
12. Choi JW, Pai SH, Im MW, Kim SK: Change in transferrin receptor concentrations with age. Clin Chem 1999;45:1562-1563.
13. Choi JW, Im MW, Pai SH: Serum transferrin receptor concentrations during normal pregnancy. Clin Chem 2000;46:725-727.
14. Kuvibidila S, Warrier RP, Ode D, Yu L: Serum transferrin receptor concentrations in women with mild malnutrition. Am J Clin Nutr 1996; 63:596-601.
15. van Iperen CE, Kraaijenhagen RJ, Biesma DH, Beguin Y, Marx JJ, van de Wiel A: Iron metabolism and erythropoiesis after surgery. Br J Surg 1998;85:41-45.
16. Suominen P, Punnonen K, Rajamaki A, Irjala K: Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998;92: 2934-2939.
17. Goodnough LT, Skikne B, Brugnara C: Erythropoietin, iron, and erythropoiesis. Blood 2000;96:823-833.
18. Punnonen K, Irjala K, Rajamaki A: Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997;89:1052-1057.
19. Looker AC, Loyevsky M, Gordeuk VR: Increased serum transferrin saturation is associated with lower serum transferrin receptor concentration. Clin Chem 1999;45:2191-2199.
20. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD: Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 1992;119:385-390.
21. Suominen P, Mottonen T, Rajamaki A, Irjala K: Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum 2000;43:1016-1020.
22. Means RT Jr, Allen J, Sears DA, Schuster SJ: Serum soluble transferrin receptor and the prediction of marrow aspirate iron results in a heterogeneous group of patients. Clin Lab Haematol 1999;21:161-167.
23. North M, Dallalio G, Donath AS, Melink R, Means RT Jr: Serum transferrin receptor levels in patients undergoing evaluation of iron stores: Correlation with other parameters and observed versus predicted results. Clin Lab Haematol 1997;19:93-97.
24. Nielsen OJ, Andersen LS, Hansen NE, Hansen TM: Serum transferrin receptor levels in anaemic patients with rheumatoid arthritis. Scand J Clin Lab Invest 1994;54:75-82.
25. Pettersson T, Kivivuori SM, Siimes MA: Is serum transferrin receptor useful for detecting iron-deficiency in anaemic patients with chronic inflammatory diseases? Br J Rheumatol 1994;33:740-744.
26. Mast AE, Blinder MA, Gronowski AM. Chumley C, Scott MG: Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 1998;44:45-51.
27. Carmel R, Skikne BS: Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency. Eur J Haematol 1992;49:246-250.
28. Rees DC, Williams TN, Maitland K, Clegg JB, Weatherall DJ: Alpha thalassaemia is associated with increased soluble transferrin receptor levels. Br J Haematol 1998;103:365-369.
29. Kohgo Y, Nishisato T, Kondo H, Tsushima N, Niitsu Y, Urushizaki I: Circulating transferrin receptor in human serum. Br J Haematol 1986;64:277-281.
30. Beguin Y, Lampertz, S, Bron D, Fillet G: Serum erythropoietin in chronic lymphocytic leukaemia. Br J Haematol 1996;93:154-156.
31. Klemow D, Einsphar D, Brown TA, Flowers CH, Skikne BS: Serum transferrin receptor measurements in hematologic malignancies. Am J Hematol 1990;34:193-198.
32. Kato J, Kohgo Y, Kondo H, Nishisato T, Sasaki K, Tsushima N, Hirayama M, Fujikawa K, Sintani N, Miyazaki E: Circulating transferrin receptor in acute leukemias. Int J Hematol 1992;56:161-165.
33. Raaf HN, Jacobsen DW, Savon S, Green R: Serum transferrin receptor level is not altered in invasive adenocarcinoma of the breast. Am J Clin Pathol 1993;99:232-237.
34. Dowlati A, Loo M, Bury T, Fillet G, Beguin Y: Soluble and cell-associated transferrin receptor in lung cancer. Br J Cancer 1997;75:1802-1806.
35. Beguin Y, Lampertz S, De Groote D, Igot D, Malaise M, Fillet G: Soluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia. Leukemia 1993;7:2019-2025.
36. Suominen P, Punnonen K, Rajamaki A, Majuri R, Hanninen V, Irjala K: Automated immunoturbidimetric method for measuring serum transferrin receptor. Clin Chem 1999;45:1302-1305.
37. Cook J: The nutritional assessment of iron status. Arch Latinoam Nutr 1999;49(3 suppl 2): 11S-14S.
38. Buhl SN, Jackson KY: Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-laclate reactions in human serum at 25, 30, and 37 degrees C. Clin Chem 1978;24:828-831.
39. ICSH: Reference method for the erythrocyte sedimentation rate (ESR) test on human blood. Br J Haematol 1973;24:671-673.
40. Bezwoda WR, Bothwell TH, Torrance JD, MacPhail AP, Charlton RW, Kay G, Levin J: The relationship between marrow iron stores, plasma ferritin concentrations and iron absorption. Scand J Haematol 1979;22:113-120.
41. R'zik S, Beguin Y: Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors. Exp Hematol 2001;29:677-685.
42. Nejmeddine F, Raphael M, Martin A, Le Roux G, Moretti JL, Caillat-Vigneron N: 67Ga scintigraphy in B-cell non-Hodgkin's lymphoma: Correlation of 67Ga uptake with histology and transferrin receptor expression. J Nucl Med 1999;40:40-45.
43. Luttropp CA, Jackson JA, Jones BJ, Sohn MH, Lynch RE, Morton KA: Uptake of gallium-67 in transfected cells and tumors absent or enriched in the transferrin receptor. J Nucl Med 1998;39:1405-1411.
44. Woith W, Nusslein I, Antoni C, Dejica DI, Winkler TH, Herrmann M, Pirner K, Kalden JR, Manger B: A soluble form of the human transferrin receptor is released by activated lymphocytes in vitro. Clin Exp Immunol 1993;92:537-542.
45. Glasova M, Konikova E, Kusenda J, Babusikova O: Flow cytometric detection of some activation and proliferation markers in human hematopoietic cell lines. Neoplasma 1996;43: 381-388.