Quantitative model calculation of the time-dependent protoporphyrin IX concentration in normal human epidermis after delivery of ALA by passive topical application or iontophoresis

Photochemistry and Photobiology

Volumn 75, Issue 4, 2002, Pages 424-432

  Star, Willem M ^a   Aalders, Maurice C G ^b   Sac, Arnoldo ^c   Sterenborg, Henricus J C M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOLEVULINIC ACID; HEME; PROTOPORPHYRIN;

ARTICLE; BLEACHING; COMPARTMENT MODEL; CONTROLLED STUDY; CYTOPLASM; DERMIS; DIFFUSION; DOSE TIME EFFECT RELATION; DRUG UPTAKE; EPIDERMIS; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IONTOPHORESIS; KINETICS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; MITOCHONDRION; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PUBLICATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SKIN; SYNTHESIS; BIOLOGICAL MODEL; METABOLISM; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AMINOLEVULINIC ACID; EPIDERMIS; HUMANS; IONTOPHORESIS; MODELS, BIOLOGICAL; PROTOPORPHYRINS;

EID: 0036549386     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2002)075<0424:QMCOTT>2.0.CO;2     Document Type: Article

References (31)

1. Aalders, M. C. G., N. van der Vange, W. M. Star and H. J. C. M. Sterenborg (2001) A mathematical evaluation of dose related PpIX fluorescence kinetics. Photochem. Photobiol. 74, 311-317.
2. Atkins, P. W. (1992) The rates of chemical reactions. In Physical Chemistry, (Edited by P. W. Atkins), pp. 777-813. Oxford University Press, Oxford.
3. Boddé, H. E., P. E. H. Roemelé and W. M. Star (2002) Quantification of topically delivered 5-aminolevulinic acid by iontophoresis across ex vivo human stratum corneum. Photochem. Photobiol. 75, 418-423.
4. Rhodes, L. E., M. M. Tsoukas, R. R. Anderson and N. Kollias (1987) Iontophoretic delivery of ALA provides a quantitative model for ALA pharmacokinetics and PpIX phototoxicity in human skin. J. Investig. Dermatol. 108, 87-91.
5. Svaasand, L. O., P. Wyss, M.-T. Wyss, Y. Tadir, B. J. Tromberg and M. W. Berns (1996) Dosimetry model for photodynamic therapy with topically administered photosensitizers. Lasers Surg. Med. 18, 139-149.
6. Scott, E. R., A. I. Laplaza, H. S. White and J. B. Phipps (1993) Transport of ionic species in skin: contribution of pores to the overall skin conductance. Pharm. Res. 10, 1699-1709.
7. Bath, B. D., H. S. White and E. R. Scott (2000) Visualization and analysis of electroosmotic flow in hairless mouse skin. Pharm. Res. 17, 471-475.
8. Abramowitz, M. and I. A. Stegun (1972) Handbook of Mathematical Fuctions. Dover Publications, New York.
9. Roberts, G. E. and H. Kaufman (1966) Table of Laplace Transforms. W. B. Saunders, London.
10. Spanier, J. and K. B. Oldham (1987) An Atlas of Functions. Hemisphere Publishing/Harper & Row, London.
11. Rud, E., O. Gederaas, A. Høgset and K. Berg (2000) 5-Aminolevulinic acid, but not 5-amonilevulinic acid esters, is transported into adenocarcinoma cells by system beta transporters. Photochem. Photobiol. 71, 640-647.
12. Ormrod, D. and B. Jarvis (2000) Topical aminolevulinic acid HCI photodynamic therapy. Am. J. Clin. Dermatol. 1, 133-139.
13. Golub, A. L., E. F. Gudgin Dickson, J. C. Kennedy, S. L. Marcus, Y. Park and R. H. Pottier (1999) The monitoring of ALA-induced protoporphyrin IX accumulation and clearance in patients with skin lesions by in vivo surface-detected fluorescence spectroscopy. Lasers Med. Sci. 14, 112-122.
14. Robinson, D. J., H. S. de Bruijn, W. J. de Wolf, H. J. C. M. Sterenborg and W. M. Star (2000) Topical 5-aminolevulinic acid therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect. Photochem. Photobiol. 72, 794-802.
15. Peng, Q., J. Moan, T. Warloe, J. M. Nesland and C. Rimington (1992) Distribution and photosensitizing efficiency of phorphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int. J. Cancer 52, 433-443.
16. Hua, Z., S. L. Gibson, T. H. Foster and R. Hilf (1994) Effectiveness of 8-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo. Cancer Res. 55, 1723-1731.
17. Henderson, B. W., L. Vaughan, D. A. Bellnier, H. van Leengoed, P. G. Johnson and A. Oseroff (1995) Photosensitization of murine tumor, vasculature and skin by 5-aminolevulinic acid-induced porphyrin. Photochem. Photobiol. 62, 780-789.
18. Löfgren, L. A., A. M. Ronn, M. Nouri, C. J. Lee, D. Yoo and B. M. Steinberg (1995) Efficacy of intravenous 8-aminolevulinic acid photodynamic therapy on rabbit papillomas. Br. J. Cancer 72, 857-864.
19. Loh, C. S., D. Vernon, A. J. MacRobert, J. Bedwell and S. G. Bown (1993) Endogenous porphyrin distribution induced by 5-aminolevulinic acid in the tissues of the gastrointestinal tract. J. Photochem. Photobiol. B: Biol. 20, 47-54.
20. Fritsch, C., P. Lehmann, W. Stahl, K. W. Schulte, E. Blohm, K. Lang, H. Sies and T. Ruzicka (1999) Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of 8-aminolevulinic acid. Br. J. Cancer 79, 1603-1608.
21. Van der Veen, N., H. S. de Bruijn, R. J. W. Berg and W. M. Star (1996) Kinetics and localisation of PpIX fluorescence after topical and systemic ALA-application, observed in skin and skin tumours of UVB-treated mice. Br. J. Cancer 73, 925-930.
22. Moan, J., L. W. Ma and V. Iani (2001) On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters. Int. J. Cancer 92, 139-142.
23. Van den Akker, J. T. H. M., V. Iani, W. M. Star, H. J. C. M. Sterenborg and J. Moan (2002) Systemic component to protoporphyrin IX production in the nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions. Photochem. Photobiol. 75(2), 172-177.
24. Gerscher, S., J. P. Connelly, G. M. J. Beijersbergen van Henegouwen, A. J. MacRobert, P. Watt and L. E. Rhodes (2001) A quantitative assessment of protoporphyrin IX metabolism and phototoxicity in human skin following dose-controlled delivery of the prodrugs 5-aminolevulinic acid and 5-aminolevulinic acid-n-pentylester. Br. J. Dermatol. 144, 983-990.
25. Robinson, D. J., P. Collins, M. R. Stringer, D. I. Vernon, G. I. Stables, S. B. Brown and R. A. Sheehan-Dare (1999) Improved response of plaque psoriasis after multiple treatments with topical 5-aminolevulinic acid photodyamic therapy. Acta. Derm.-Venereol. 79, 451-455.
26. Wennberg, A.-M., O. Larkö, P. Lönnroth, G. Larson and A.-L. Krogstad (2000) Delta-aminolevulinic acid in superficial basal cell carcinoma and normal skin - a microdialysis and perfusion study. Clin. Exp. Dermatol. 25, 317-322.
27. Lange, N., P. Jichlinski, M. Zellweger, M. Forrer, A. Marti, L. Guillou, P. Kucera, G. Wagnières and H. E. van den Bergh (1999) Photodetection of early human bladder cancer based on the fluorescence of 5-aminolevulinic acid hexyl ester-induced protoporphyrin IX: a pilot study. Br. J. Cancer 80, 185-193.
28. Peng, Q., T. Warloe, K. Berg, J. Moan, M. Kongshaug, K.-E. Giercksky and J. M. Nesland (1997) 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer 79, 2282-2308.
29. Van der Veen, N. (2000) Mechanism and optimization of PDT using ALA induced PpIX. Ph.D. thesis, Erasmus University Rotterdam.
30. Turner, N. G. and R. H. Guy (1998) Visualization and quantitation of iontophoretic pathways using confocal microscopy. J. Investig. Dermatol. Symp. Proc. 3, 136-142.
31. Meijnders, P. J. N., W. M. Star, H. S. de Bruijn, A. D. Treurniet-Donker, M. J. M. van Mierlo, S. J. M. Wijthoff, B. Naafs, H. Beerman and P. C. Levendag (1996) Clinical results of photodynamic therapy for superficial skin malignancies or actinic keratosis using topical 5-aminolevulinic acid. Lasers Med. Sci. 11, 123-131.