Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: A pilot study

British Journal of Cancer

Volumn 80, Issue 1-2, 1999, Pages 185-193

  Lange, N ^a   Jichlinski, P ^b   Zellweger, M ^a   Forrer, M ^a   Marti, A ^b   Guillou, L ^b   Kucera, P ^c   Wagnieres G ^a   Van Den Bergh, H ^a  

^a EPFL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

5 aminolaevulinic acid; 5 aminolaevulinic acid hexylester; Fluorescence; Human bladder cancer; Photodynamic therapy; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; ESTER DERIVATIVE; GLASS FIBER; PROTOPORPHYRIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; CHEMICAL MODIFICATION; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; FLUORESCENCE; HUMAN; HUMAN TISSUE; INTRAVESICAL DRUG ADMINISTRATION; LIPOPHILICITY; MALE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

EID: 0345407181     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690338     Document Type: Article

References (46)

1. Berg K, Anholt H, Bech O and Moan J (1996) The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells! Br J Cancer 74: 688-697
2. Bezdetnaya L, Zeghari N, Belitchenko I, Berberi-Heyob M, Merlin JL, Potapenko A and Guillemin F (1996) Spectroscopic and biological testing of photobleaching of porphyrins in solutions. Photochem Photobiol 64: 382-386
3. Bridges JW, Sargent NSE and Upshall DG (1979) Rapid absorption from the urinary bladder of a series of n-alkyl carbamate: a route for the recirculation of drug. Br J Pharmacol 66: 283-289
4. Chang SG, MacRobert AJ and Bown SG (1996) Biodistribution of protoporphyrin IX in rat urinary bladder after intravesical instillation of 5-aminolaevulinic acid. J Urol 155: 1744-1748
5. Chang SG, MacRobert AJ, Porter JB and Bown SG (1997) The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following 5-aminolaevulinic acid administration: an in vivo study. J Photochem Photobiol B 38: 114-122
6. Cox GS, Bobillier C, Whitten DG (1982) Photo-oxidation and singlet oxygen sensitization by protoporphyrin IX and its photo-oxidation products. Photochem Photobiol 36: 401-407
7. Dougherty TJ, Cooper MT and Mang TS (1990). Cutaneous phototoxic occurrences in patients receiving Photofrin. Lasers Surg Med 10: 485-488
8. Fraga CG, Onuki J, Lucesoli F, Bechara EJ and Di Mascio P (1994) 5-Aminolaevulinic acid mediates the in vivo and in vitro formation of 8-hydroxy-2'-deoxyguanosine in DNA. Carcinogenesis 15: 2241-2244
9. Fukuda H, Paredes S and Del Battle AM (1992) Tumor localizing properties of porphyrins in vivo studies using free and liposome encapsulated aminolaevulinic acid. Comp Biochem Physiol 102b: 433-436
10. Gaullier JM, Berg K, Peng Q, Anholt H, Selbo PK, Ma LW and Moan J (1997) Use of 5-aminolaevulinic acid esters to improve photodynamic therapy on cells in culture. Cancer Res 57: 1481-1486
11. Hanania J and Malik Z (1992) The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human leukemic cells. Cancer Lett 65: 127-131
12. Hermanek P and Sobin J (1992) UICC TNM Classification of Malignant Tumours, 4th edn. Springer Verlag: Berlin
13. 2+ and 5-aminolaevulinic acid-derived oxyradicals promote injury to isolated mitochondria? Free Radical Biol Med 19: 381-390
14. Iinuma S, Bachor R, Flotte T and Hasan T (1995). Biodistribution and phototoxicity of 5-aminolaevulinic acid-induced PpIX in an orthotopic rat bladder tumor model. J Urol 153: 802-806
15. Jain RK (1987a) Transport of molecules in the tumor interstitium: a review. Cancer Res 47: 3039-3305
16. Jain RK (1987b). Transport of molecules across tumor vasculature. Cancer Metast Rev 6: 559-593
17. Jichlinski P, Forrer M, Mizeret J, Glanzmann T, Braichotte D, Wagniéres G, Zimmer G, Guillou L, Schmidlin FM, Graber P, van den Bergh H and Leisinger HJ (1997) Clinical evaluation of a method for detecting superficial transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following topical application of 5-aminolaevulinic acid: preliminary results. Lasers Surg Med 20: 402-408
18. Kennedy JC, Pottier RH and Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol. B 6: 143-148
19. Kloek J and Beijersbergen van Henegouwen GMJ (1996) Prodrugs of 5-aminolaevulinic acid for photodynamic therapy. Photochem Photobiol 64: 994-1000
20. Kriegmair A, Baumgartner R, Knuechel R, Steinbach P, Ehsan A, Lumper W, Hofstaeder W and Hofstetter A (1994) Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolaevulinic acid. Urology 44: 836-841
21. Kriegmair M, Baumgartner R, Lumper W, Waidelich R and Hofstetter A (1996) Early clinical experience with 5-aminolaevulinic acid for the photodynamic therapy of superficial cancer. Br J Urol 77: 667-671
22. Leveckis J, Burn JL, Brown NJ and Reed MWR (1994) Kinetics of endogeneous protoporphyrin IX induction by aminolaevulinic acid: preliminary studies in the bladder. J Urol 152: 550-553
23. Levi F (1993) Incidence of infiltrating cancer following superficial bladder carcinoma. Int J Cancer 55: 419-421
24. Loh CS, Vernon D, MacRobert AJ, Bedwell J, Bown SG and Brown SB (1993) Endogenous porphyrin distribution induced by 5-aminolevulinic acid in tissue layers of the gastrointestinal tract. Photochem Photobiol 20: 47-54
25. Marti A, Lange N, van den Bergh H, Sedmera D, Jichlinski P and Kuchera P (1998) Optimalisation of the formation and distribution of protoporphyrin IX in the urothelium: an in vitro approach. J Urol (in press)
26. Moan J, Streckyte G, Bagdonas S, Bech O and Berg K (1997) Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int J Cancer 70: 90-97
27. Mostofio FK, Sobin LH and Torloni H (1973) Histological typing of urinary bladder tumors. In International Histological Classification of Tumors. World Health Organization Geneva
28. Nagy GK, Frable WJ and Murphy WM (1982) Classification of premalignant urothelial abnormalities: A Delphi study of the National Bladder Cancer Collaborative Group A. In Sommers SC and Rosen PP (eds) pp. 219-233 Appleton: Norwalk, CT
29. Novo M, Huettmann G and Diddens H (1996) Chemical instability of 5-aminolaevulinic acid used in the fluorescence diagnosis of bladder tumours. J Photochem Photobiol B 34: 143-148
30. Orenstein A, Kostenich G, Tsur H, Roitman L, Ehrenberg B and Malik Z (1995) Photodynamic therapy of human skin tumors using topical application of 5-aminolaevulinic acid, DMSO and EDTA. Proc SPIE 2325: 100-105
31. Ortel B, Tanew A and Honigsmann H (1993) Lethal photosensitization by endogenous porphyrins of PAM cell-modification by desferrioxamine. J Photochem Photobiol B 17: 273-278
32. Peng Q, Moan J, Warlow T, Nesland JM and Rimington C (1992) Distribution and photosensitizing efficiency of porphyrins induced by application of endogenous 5-aminolaevulinic acid in mice bearing mammary carcinoma. Int J Cancer 52: 433-443
33. Peng Q, Warloe T, Moan J, Heyerdahl H, Steen HB, Nesland JM and Giercksky KE (1995) Distribution of 5-aminolaevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma. Photochem Photobiol 62: 906-913
34. Peng Q, Moan J, Warloe T, Irani V, Steen HB, Bjorseth A and Nesland JM (1996) Build-up of esterified aminolaevulinic-acid-derivative-induced porphyrin fluorescence in normal mouse skin. J Photochem Photobiol B 34: 96-96
35. Rebeiz N, Arkins S, Rebebeiz CA, Simon J, Zachary JF and Kelly KW (1996) Induction of tumour necrosis by δ-aminolaevulinic acid and 1,10-phenanthroline photodynamic therapy. Cancer Res 56: 339-344
36. Richie JP, Shipley WU and Yagoda A (1989) Cancer of the bladder. In Cancer Principles and Practice of Oncology, De Vita VT, Hellmann S and Rosenberg SA (eds), pp. 1008-1020. JB Lippincott: Philadelphia
37. Rick K, Sroka R, Stepp H, Kriegmair M, Huber RM and Baumgartner R (1997) Pharmacokinetics of 5-aminolaevulinic acid-induced protoporphyrin IX in skin and blood. J Photochem Photobiol B 40: 319-313
38. Rotomski R, Bagdonas S and Streckyte G (1996) Spectroscopic studies of photobleaching and photoproduct formation of porphyrins used in tumour therapy. J Photochem Photobiol B 33: 61-67
39. Schoenfeld N, Mamet R, Norenberg Y, Shafran M, Babuskin T and Malik Z (1994) Protoporphyrin biosynthesis in melanoma B 16 cells stimulated by 5-aminolaevulinic acid and chemical inducers: characterization of photodynamic inactivation. Int J Cancer 56: 106-112
40. Steinbach P, Kriegmair M, Baumgartner R, Hofstadter F and Knuechel R (1994) Intravesical instillation of 5-aminolaevulinic acid: the fluorescent metabolite is limited to urothelial cells. Urology 44: 676-681
41. Svanberg K, Andersson T, Killander D, Wang I, Stenram U, Andersson-Engels S, Berg R, Johansson J and Svanberg S (1994) Photodynamic therapy of non-melanoma malignant tumors of the skin using topical d-aminolaevulinic acid sensitization and laser irradiation. Br J Dermatol 130: 743-751
42. Takeya H (1992) Preparation of 5-aminolaevulinic acid alkyl esters as herbicides. Chem Abstr 116: P189633
43. Tyrrell RM, Pourzand C and van den Bergh H (1993) Unpublished results
44. Wagnière S, Hadjur C, Grosjean P, Braichotte D, Savary JF, Monnier P and van den Bergh H (1998) Clinical evaluation of cutaneous phototoxicity of 5, 10, 15, 20-tetra (m-hydroxyphenyl) chlorin. Photochem Photobiol 68: 382-387
45. Warloe T, Peng Q, Steen HB and Gierchsky KE (1992) Localization of porphyrins in human basal cell carcinoma and normal tissue induced by topical application of 5-aminolaevulinic acid. In Photodynamic Therapy and Biomedical Lasers, Spinelli P, Dal Fante M and Marchesini R (eds), pp. 454-458. Elvesier Science: Amsterdam
46. Warloe T, Peng Q, Heyerdahl H, Moan J, Stenn HB and Giercksky KE (1995) Photodynamic therapy with 5-aminolaevulinic acid induced porphyrins and DMSO/EDTA for basal cell carcinoma. Proc SPIE 2371: 226-235