Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of δ-aminolaevulinic acid

British Journal of Cancer

Volumn 79, Issue 9-10, 1999, Pages 1603-1608

  Fritsch, C ^a   Lehmann, P ^a   Stahl, W ^a   Schulte, K W ^a   Blohm, E ^a   Lang, K ^a   Sies, H ^a   Ruzicka, T ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aminolaevulinic acid; Basal cell carcinoma; Photodynamic therapy; Porphyrin metabolites; Psoriasis; Squamous cell carcinoma

Indexed keywords

AMINOLEVULINIC ACID; PHOTOSENSITIZING AGENT; PORPHYRIN; PROTEIN; PROTOPORPHYRIN; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL CARCINOMA; BIOSYNTHESIS; CLINICAL PROTOCOL; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NERIBAS; PHOTODYNAMIC THERAPY; PORPHYRIN METABOLISM; PRIORITY JOURNAL; PSORIASIS; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TISSUE LEVEL; TOPICAL DRUG ADMINISTRATION; TREATMENT PLANNING;

EID: 0033052660     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690255     Document Type: Article

References (36)

1. Abels C, Heil P, Dellian M, Kuhnle GEH, Baumgartner R and Goetz AE (1994) In vivo kinetics and spectra of 5-aminolevulinic acid induced fluorescence in an amelanotic melanoma of the hamster. Br J Cancer 70: 826-833
2. Bloomer JR, Brenner DA and Mahoney MJ (1997) Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. J Clin Invest 60: 1354-1361
3. Boehncke WH, Sterry W and Kaufmann R (1994) Treatment of psoriasis by topical photodynamic therapy with polychromatic light. Lancet 343: 801
4. Bolsen K, Lang K, Verwohlt B, Fritsch C and Goerz G (1996) In vitro induction of porphyrin biosynthesis in various human cells after incubation with δ-aminolevulinic acid. Arch Dermatol Res 288: 320A
5. Calzavara-Pinton PG (1995) Repetitive photodynamic therapy with topical δ-aminolevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J Photochem Photobiol B: Biol 29: 53-57
6. Fritsch C, Becker-Wegerich PM, Schulte KW, Neuse W, Lehmann P, Ruzicka T and Goerz G (1996a) Treatment of a large superficial basal cell carcinoma of the breast with combination of photodynamic therapy and surgery controlled by photodynamic diagnosis. Hautarzt 47: 438-442
7. Fritsch C, Verwohlt B, Bolsen K, Ruzicka T and Goerz G (1996b) Influence of topical photodynamic therapy with 5-aminolevulinic acid on the porphyrin metabolism. Arch Dermatol Res 288: 517-521
8. Fritsch C, Abels C, Goetz G, Stahl W, Bolsen K, Ruzicka T, Goerz G and Sies H (1997a). Porphyrins preferentially accumulate in a melanoma following intravenous injection of 5-aminolevulinic acid. Biol Chem 378: 51-57
9. Fritsch C, Neuse W, Ruzicka T and Goerz G (1997b) Photodynamische Diagnostik in der Dermatologie. In Handbuch der Dermatologischen Phototherapie und Photodiagnostik. Krutman J, Hönigsmann H (eds) pp. 331-356. Springer: Berlin
10. Fritsch C, Batz J, Bolsen K, Schulte KW, Zumdick M, Ruzicka T and Goerz G (1997c) Ex-vivo application of ALA induces high and specific porphyrin levels in human skin tumors. Possible basis for selective photodynamic therapy Photochem Photobiol 66: 114-118
11. Fritsch C, Goerz G and Ruzicka T (1997d) Photodynamic therapy in dermatology. A review. Arch Dermatol 134: 207-214
12. Fritsch C, Homey B, Stahl W, Lehmann P, Ruzicka T and Sies H (1998) Preferential relative porphyrin enrichment in solar keratoses upon topical application of δ-aminolevulinic acid methylester. Photochem Photobiol 68: 218-221
13. Goerz G, Link-Mannhardt N, Bolsen K, Zumdick M, Fritsch C and Schürer NY (1995) Porphyrin concentrations in various human tissues. Exp Dermatol 4: 218-228
14. Goetz AE Lumper W, Fritsch C, Müller W, Feyh J, Conzen P and Brendel W (1990) Changes in tumor and adjacent tissue perfusion after photodynamic therapy. Eur Surg Res 22: (Suppl 1): 59
15. Goff B, Bachor R, Kollias N, Hasan T (1992) Effects of photodynamic therapy with topical application of 5-aminolevulinc acid on normal skin of hairless guinea pigs. J Photochem Photobiol B 15: 139-251
16. Grant WE, Hopper C, Macrobert AJ, Speight PM and Bown SG (1993) Photodynamic therapy of oral cancer, photosensitisation with systemic aminolevulinic acid. Lancet 342: 147-149
17. Hanania J and Malik Z (1992) The effect of EDTA and serum on endogenous porphyrin accumulation and photodynamic sensitization of human K562 leukemic cells. Cancer Lett 65: 127-131
18. Hua Z, Gibson SL, Foster TM and Hilf R (1995) Effectiveness of δ-aminolevulinic acid-induced protoporphyrin as a photosensitizer for photodynamic therapy in vivo. Cancer Res 55: 1723-1731
19. Iinuma S, Bachor R, Flotte T, Hasan T (1995) Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model. J Urology 153: 802-806
20. Kennedy JC, Pottier RH and Pross DC (1990) Photodynamic therapy with endogenous proloporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol 6: 143-148
21. Kriegmair M, Baumgartner R, Knüchel R, Stepp H, Hofstädter F and Hofstetter A (1996) Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence, J Urol 155: 105-109
22. Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
23. Malik Z, Kostenich G, Roitman L, Ehrenberg B and Orenstein A (1995) Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumours of mice. J Photochem Photobiol B: Biol 28: 213-218
24. Martin A, Tope WD, Grevelink JM, Starr JC, Fewkes JL, Flotte TJ, Deutsch TF and Anerson RR (1995) Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic therapy. Arch Dematol Res 287: 665-674
25. Pass HI (1993) Photodynamic therapy in oncology: mechanisms and clinical use. J Natl Cancer Inst 85: 443-453
26. Peng Q, Moan J, Warloe T, Nesland JM and Rimington C (1992) Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int J Cancer 52: 433-443
27. Peng Q, Warloe T, Moan J, Heyerdahl H, Steen HB, Nesland JM and Giercksky GE (1995). Distribution of 5-aminolevulinic acid-induced porphyrins in noduloulcerative basal cell carcinoma. Photochem Photobiol 62: 906-913
28. Regula J, Macrobert AJ, Gorchein A, Buonaccorsi GA, Thorpe SM, Spencer GM, Hatfield ARW and Bown SG (1994) Photosensitization and photodynamic therapy of esophageal, duodenal, and colorectal tumours using 5-aminolaevulinic acid induced protoporphyrin IX - a pilot study. Gut 36: 67-75
29. Seubert A and Seubert S (1982) High-performance liquid chromatographic analysis of porphyrins and their isomers with radial compression columns. Anal Biochem 124: 303-307
30. Sroka R, Beyer W, Gossner L, Sassy T, Stocker S and Baumgartner R (1996) Pharmacokinetics of 5-aminolevulinic-acid-induced porphyrins in tumour-bearing mice. Photochem Photobiol B: Biol 34: 13-19
31. Stringer MR, Collins P, Robinson DJ, Stables GI and Sheehan-Dare RA (1996) The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for photodynamic therapy. J Invest Dermatol 107: 76-81
32. Svanberg K, Anderson T, Killander D, Wang I, Stenram U, Andersson-Engels S, Berg R, Johansson J and Svanberg S (1994) Photodynamic therapy of non-melanoma malignant tumours of the skin using topical δ-amino levulinic acid sensitization and laser irradiation. Br J Dermatol 130: 743-751
33. Szeimies RM, Sassay T and Landthaler M (1994) Penetration potency of topical applied delta aminolevulinic acid for photodynamic therapy of basal cell carcinoma. Photochem Photobiol 59: 73-76
34. Veen van der N, Bruijn de HS, Berg RJW, Star WM (1996) Kinetics and localisation of PpIX fluorescence after topical and systemic ALA application, observed in skin and skin tumours of UVB-treated mice. Br J Cancer 73: 925-930
35. Warloe T, Peng Q, Steen HB and Giercksky KE (1992) Localization of porphyrins in human basal cell carcinoma and normal skin tissue induced by topical application of 5-aminolevulinic acid. In Photodynamic Therapy and Biomedical Lasers. Spinelli P, Del Fante M, Marchesini R (eds) pp. 454-458. Elsevier Science Publishers B. V., Milan
36. Wolf P. Rieger E and Kerl H (1993) Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid. J Am Acad Dermatol 28: 17-21