Protein folding: The free energy surface

Current Opinion in Structural Biology

Volumn 12, Issue 2, 2002, Pages 161-168

  Gruebele, Martin ^a  

^a University of Illinois at Urbana Champaign   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTOGLOBULIN; GLOBULAR PROTEIN;

AMINO ACID SEQUENCE; ENERGY TRANSFER; ENTROPY; MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REVIEW; SIMULATION; THERMODYNAMICS;

EID: 0036535895     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(02)00304-4     Document Type: Review

References (56)

1. Special issue on protein folding
2. Theory of protein folding: The energy landscape perspective
3. Protein folding: A perspective from theory and experiment
4. The physical chemistry of protein folding
5. Polymer principles and protein folding
6. A surprising simplicity to protein folding
7. Characterizing transition states in protein folding: An essential step in the puzzle
8. Theoretical studies of protein-folding thermodynamics and kinetics
9. Reaction coordinates of biomolecular isomerization
10. A salt-induced kinetic intermediate is on a new parallel pathway of lysozyme folding
11. Understanding beta-hairpin formation
12. Time-resolved infrared study of the helix-coil transition using C-13-labeled helical peptides
13. A new twist on the helix-coil transition: A non biological helix with protein-like intermediates and traps
14. Transition from exponential to nonexponential kinetics during formation of an artificial helix
15. How does a beta-hairpin fold/unfold? Competition between topology and heterogeneity in a solvable model
16. Mechanisms and kinetics of beta-hairpin formation
17. Critical role of beta-hairpin formation in protein G folding
18. The folding mechanism of a β-sheet: The WW domain
19. The structural basis of protein folding and its links with human disease
20. Folding-unfolding equilibrium and kinetics of equine beta-lactoglobulin: Equivalence between the equilibrium molten globule state and a burst-phase folding intermediate
21. What is the role of non-native intermediates of β-lactoglobulin in protein folding
22. Protein folding as a diffusional process
23. Energetic frustration and the nature of the transition state ensemble in protein folding
24. Microscopic theory of protein folding rates. II. Local reaction coordinates and chain dynamics
25. Backbone dynamics, fast folding, and secondary structure formation in helical proteins and peptides
26. Measuring the rate of intramolecular contact formation in polypeptides
27. The speed limit of protein folding measure by triplet-triplet energy transfer
28. Denaturant-induced movement of the transition state of protein folding revealed by high-pressure stopped-flow measurements
29. Investigation of routes and funnels in protein folding by free energy functional methods
30. Prediction of protein-folding mechanisms from free energy landscapes derived from native structures
31. Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate
32. Observation of strange kinetics in protein folding
33. Role of explicitly cooperative interactions in protein folding funnels: A simulation study
34. Energetic components of cooperative protein folding
35. Water clusters: Untangling the mysteries of the liquid one molecule at a time
36. Two-state expansion and collapse of a polypeptide
37. A statistical appraisal of native state hydrogen exchange data: Evidence for a burst phase continuum?
38. Protein folding on a complex energy landscape
39. Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems
40. Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation
41. From snapshot to movie: Phi analysis of protein folding transition states taken one step further
42. Intermediates can accelerate protein folding
43. Transition states and the meaning of the φ-values in protein folding kinetics
44. A theoretical search for folding/unfolding nuclei in three-dimensional protein structures
45. Topological and energetic factors: What determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteins
46. Protein folding intermediates and pathways studied by hydrogen exchange
47. Chain collapse can occur concomitantly with the rate-limiting step in protein folding
48. Pressure provides new insights into protein folding, dynamics and structure
49. Mapping the transition state of the WW domain beta sheet
50. Computer-based redesign of a protein folding pathway
51. Building blocks, hinge-bending motions and protein topology
52. Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
53. A simple model for calculating the kinetics of protein folding from three-dimensional structures
54. Effect of H helix destabilizing mutations on the kinetic and equilibrium folding of apomyoglobin
55. Cytochrome c′ folding triggered by electron transfer: Fast and slow formation of four-helix bundles
56. Nuclear magnetic resonance methods for elucidation of structure and dynamics in disordered states