Thymidylate synthase levels: Prognostic, predictive, or both?

Journal of Clinical Oncology

Volumn 20, Issue 7, 2002, Pages 1711-1713

  Allegra, Carmen ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

CANCER SURVIVAL; EDITORIAL; ENZYME LOCALIZATION; HUMAN; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TREATMENT OUTCOME;

EID: 0036533805     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2002.20.7.1711     Document Type: Editorial

References (16)

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
2. Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
3. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
4. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
5. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
6. Thymidylate synthase and p 53 primary tumour expression as predictive factors for advanced colorectal cancer patients
7. Lack of correlation between thymidylate synthase levels in primary colorectal tumours, and subsequent response to chemotherapy
8. Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil
9. Difference of thymidylate synthase gene expression in primary colorectal cancer and various metastatic sites
10. Relation between thymidylate synthase expression and survival in colon carcinoma, and determination of appropriate application of 5-fluorouracil by immuno-histochemical method
11. A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance
12. Thymidylate synthase genotype and survival benefit from chemotherapy in patients with colorectal cancer
13. Prognostic value of thymidylate synthase (TS), Ki-67 and p53 in patients (pts) with Dukes' B & C colon cancer
14. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer
15. Molecular predictors of survival after adjuvant chemotherapy for colon cancer
16. Human thymidylate synthase gene polymorphism determines response to 5-FU chemotherapy