Cytoskeletal changes induced by excess extracellular matrix impair endothelial cell replication

Diabetologia

Volumn 40, Issue 8, 1997, Pages 879-886

  Podesta F ^a   Roth, T ^a   Ferrara, F ^b   Cagliero, E ^a   Lorenzi, M ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Cytochalasin D; Diabetic microangiopathy; Endothelial cells; F actin; Fibronectin; Focal adhesion; Proliferation

Indexed keywords

CYTOCHALASIN D; FIBRONECTIN;

ADULT; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC ANGIOPATHY; FEMALE; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ACTINS; ANTIGENS, CD29; CELL ADHESION; CELL DIVISION; CELLS, CULTURED; CYTOCHALASIN D; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUCOSE; HUMANS; NUCLEIC ACID SYNTHESIS INHIBITORS; UMBILICAL VEINS; VINCULIN;

EID: 0030851282     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050763     Document Type: Article

References (29)

1. von der Mark K, von der Mark H, Goodman S (1992) Cellular responses to extracellular matrix. Kidney Int 41: 632-640
2. Streuli CH, Schmidhauser C, Bailey N et al. (1995) Laminin mediates tissue-specific gene expression in mammary epithelia. J Cell Biol 129: 591-603
3. Woodley DT, O'Keefe EJ, Prunieras M (1985) Cutaneous wound healing: a model for cell-matrix interactions. J Am Acad Dermatol 12: 420-433
4. Lorenzi M, Cagliero E (1991) Pathohiology of endothelial and other vascular cells in diabetes mellitus. Call for data. Diabetes 40: 653-659
5. Steffes MW, Østerby R, Chavers B, Mauer SM (1989) Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients. Diabetes 38: 1077-1081
6. DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA (1993) Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol 122: 729-737
7. Madri JA, Pratt BM, Yannariello-Brown J (1988) Matrix-driven cell size change modulates aortic endothelial cell proliferation and sheet migration. Am J Pathol 132: 18-27
8. Newton LK, Yung WKA, Cree Pettigrew L, Steck PA (1990) Growth regulatory activities of endothelial extracellular matrix: mediation by transforming growth factor-β. Exp Cell Res 190: 127-132
9. Paige K, Palomares M, D'Amore PA, Braunhut SJ (1991) Retinol-induced modifications of the extracellular matrix of endothelial cells: its role in growth control. In Vitro Cell Dev Biol 27A:151-157
10. Engerman RL, Pfaffenbach D, Davis MD (1967) Cell turnover of capillaries. Lab Invest 17: 738-743
11. Mizutani M, Kern TS, Lorenzi M (1996) Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 97: 2883-2890
12. Cagliero E, Roth T, Roy S, Lorenzi M (1991) Characteristics and mechanisms of high glucose-induced overexpression of basement membrane components in cultured human endothelial cells. Diabetes 40: 102-110
13. Roth T, Podestá F, Stepp MA, Boeri D, Lorenzi M (1993) Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy. Proc Natl Acad Sci USA 90: 9640-9644
14. Cagliero E, Maiello M, Boeri D, Roy S, Lorenzi M (1988) Increased expression of basement membrane components in human endothelial cells cultured in high glucose. J Clin Invest 82: 735-738
15. Schliwa M (1982) Action of cytochalasin D on cytoskeletal networks. J Cell Biol 92: 79-91
16. Roy S, Cagliero E, Lorenzi M (1996) Fibronectin overexpression in retinal microvessels of patients with diabetes. Invest Ophthalmol Vis Sci 37: 258-266
17. Fava RA, McClure DB (1987) Fibronectin-associated transforming growth factor. J Cell Physiol 131: 184-189
18. Cagliero E, Roth T, Taylor AW, Lorenzi M (1995) The effects of high glucose on human endothelial cell growth and gene expression are not mediated by transforming growth factor-β. Lab Invest 73: 667-673
19. Burridge K, Fath K, Kelly T, Nuckolls G, Turner C (1988) Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Ann Rev Cell Biol 4: 487-525
20. Nugent MA, Newman MJ (1989) Inhibition of normal rat kidney cell growth by transforming growth factor-β is mediated by collagen. J Biol Chem 264: 18060-18067
21. Segarini PR, Rosen DM, Seyedin SM (1989) Binding of transforming growth factor-b to cell surface proteins varies with cell type. Mol Endocrinol 3: 261-272
22. Kumazaki T, Kobayashi M, Mitsui Y (1993) Enhanced expression of fibronectin during in vivo cellular aging of human vascular endothelial cells and skin fibroblasts. Exp Cell Res 205: 396-402
23. Goldstein S (1990) Replicative senescence: the human fibroblast comes of age. Science 249: 1129-1133
24. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 988: 73-97
25. + antiporter: assessment of effects on intracellular pH. EMBO J 12: 5209-5218
26. + exchanger in human endothelial cells cultured in high glucose. Diabetologia 38: 785-791
27. + exchanger in human endothelial cells cultured on high concentrations of fibronectin. J Am Soc Nephrol 6: 907 (Abstract)
28. + exchanger (NHE) in OKP cells. J Am Soc Nephrol 5: 254 (Abstract)
29. Clark EA, Brugge JS (1995) Integrins and signal transduction pathways: the road taken. Science 268: 233-239