Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens

Journal of Autoimmunity

Volumn 18, Issue 2, 2002, Pages 131-138

  Pontes De Carvalho, Lain ^a,b   Santana, Cláudia C ^a   Soares, Milena B P ^a   Oliveira, Geraldo G S ^a   Cunha Neto, Edecio ^c   Ribeiro Dos Santos, Ricardo ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b ESCOLA BAHIANA DE MEDICINA E SAÚDE PÚBLICA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anti CD4; Chagas' disease; Experimental autoimmune myocarditis; Immunological tolerance; Trypanosoma cruzi

Indexed keywords

FREUND ADJUVANT; HEART ANTIGEN; OKT 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CHAGAS DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; TREATMENT OUTCOME; TRYPANOSOMA CRUZI;

EID: 0036525519     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2001.0574     Document Type: Article

References (35)

1. World Health Organization, 1991, Control of Chagas' disease.
2. Dias J.C.P., Coura J. Clínica e terapêutica da doença de Chagas: uma abordagem prática para o clínico geral. 1997;FIOCRUZ, Rio de Janeiro. p. 486.
3. Andrade Z.A. Immunopathology of Chagas disease. Mem. Inst. Oswaldo Cruz. 94:1999;71-80.
4. Köberle F. Chagas' disease and Chagas' syndromes: the pathology of American Trypanosomiasis. Adv. Parasitol. 6:1968;63-116.
5. Soares M.B., Silva-Mota K.N., Lima R.S., Bellintani M.C., Pontes-de-Carvalho L., Ribeiro-dos-Santos R. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. Am. J. Pathol. 159:2001;703-709.
6. Cunha-Neto E., Duranti M., Gruber A., Zingales B., De Messias I., Stolf N., Bellotti G., Patarroyo M.E., Pilleggi F., Kalil J. Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc. Natl. Acad. Sci. USA. 92:1995;3541-3545.
7. Ribeiro dos Santos R., Rossi M.A., Laus J.L., Silva J.S., Savino W., Mengel J. Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi. J. Exp. Med. 175:1992;29-39.
8. Leon J.S., Engman D.M. Autoimmunity in Chagas heart disease. Int. J. Parasitol. 31:2001;555-561.
9. Tarleton R.L. Parasite persistence in the aetiology of Chagas disease. Int. J. Parasitol. 31:2001;550-554.
10. Kierszenbaum F. Chagas' disease and the autoimmunity hypothesis. Clin. Microbiol. Rev. 12:1999;210-223.
11. Tarleton R.L., Zhang L., Downs M.O. 'Autoimmune rejection' of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue. Proc. Natl. Acad. Sci. USA. 94:1997;3932-3937.
12. Rizzo L.V., Cunha-Neto E., Teixeira A.R. Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4+ T cells against myosin in mice chronically infected with Trypanosoma cruzi. Infect. Immun. 57:1989;2640-2644.
13. Tibbetts R.S., McCormick T.S., Rowland E.C., Miller S.D., Engman D.M. Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi -infected mice. J. Immunol. 152:1994;1493-1499.
14. Cunha-Neto E., Coelho V., Guilherme L., Fiorelli A., Stolf N., Kalil J. Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. J. Clin. Invest. 98:1996;1709-1712.
15. Ribeiro-Dos-Santos R., Mengel J.O., Postol E., Soares R.A., Ferreira-Fernandez E., Soares M.B., Pontes-De-Carvalho L.C. A heart-specific CD4+ T-cell line obtained from a chronic chagasic mouse induces carditis in heart-immunized mice and rejection of normal heart transplants in the absence of Trypanosoma cruzi. Parasite Immunol. 23:2001;93-101.
16. Qin S.X., Wise M., Cobbold S.P., Leong L., Kong Y.C., Parnes J.R., Waldmann H. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur. J. Immunol. 20:1990;2737-2745.
17. Hutchings P., O'Reilly L., Parish N.M., Waldmann H., Cooke A. The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice. Eur. J. Immunol. 22:1992;1913-1918.
18. Federici E.E., Albbermann W.N., Neva F.A. Chronic and progressive myocarditis in C3H mice infected with Trypanosoma cruzi. Am. J. Trop. Med. Hyg. 13:1964;272-280.
19. Camargo E.P. Growth and differentiation of Trypanosoma cruzi. Origin of metacyclic trypanosomes in liquid media. Rev. Inst. Med. Trop. Sao Paulo. 6:1964;93-100.
20. Margossian S.S., Lowey S. Preparation of myosin and its subfragments from rabbit skeletal muscle. Meth. Enzymol. 85:1982;55-71.
21. Olivares-Villagomez D., McCurley T.L., Vnencak-Jones C.L., Correa-Oliveira R., Colley D.G., Carter C.E. Polymerase chain reaction amplification of three different Trypanosoma cruzi DNA sequences from human chagasic cardiac tissue. Am. J. Trop. Med. Hyg. 59:1998;563-570.
22. Palomino S.A., Aiello V.D., Higuchi M.L. Systematic mapping of hearts from chronic chagasic patients: the association between the occurrence of histopathological lesions and Trypanosoma cruzi antigens. Ann. Trop. Med. Parasitol. 94:2000;571-579.
23. Andrade S.G., Pimentel A.R., de Souza M.M., Andrade Z.A. Interstitial dendritic cells of the heart harbor Trypanosoma cruzi antigens in experimentally infected dogs: importance for the pathogenesis of chagasic myocarditis. Am. J. Trop. Med. Hyg. 63:2000;64-70.
24. Barbosa A.A. Jr, Andrade Z.A. Identificação do Trypanosoma cruzi nos tecidos extracardíacos de portadores de miocardite crônica chagásica. Rev. Soc. Bras. Med. Trop. 17:1984;123-126.
25. Buckner F.S., Wilson A.J., Van Voorhis W.C. Detection of live Trypanosoma cruzi in tissues of infected mice by using histochemical stain for beta-galactosidase. Infect. Immun. 67:1999;403-409.
26. Rose N.R., Hill S.L. The pathogenesis of postinfectious myocarditis. Clin. Immunol. Immunopathol. 80:1996;S92-S99.
27. Leon J.S., Godsel L.M., Wang K., Engman D.M. Cardiac myosin autoimmunity in acute Chagas' heart disease. Infect. Immun. 69:2001;5643-5649.
28. Abel L.C.J., Kalil J., Cunha-Neto E. Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin. Braz. J. Med. Biol. Res. 30:1997;1305-1308.
29. Ben-Nun A., Wekerle H., Cohen I.R. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature. 292:1981;60-61.
30. Wang Y., Afanasyeva M., Hill S.L., Kaya Z., Rose N.R. Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice. J. Am. Coll. Cardiol. 36:2000;1992-1999.
31. Godsel L.M., Wang K., Schodin B.A., Leon J.S., Miller S.D., Engman D.M. Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance. Circulation. 103:2001;1709-1714.
32. Phillips J.M., Harach S.Z., Parish N.M., Fehervari Z., Haskins K., Cooke A. Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cells. J. Immunol. 165:2000;1949-1955.
33. Marshall S.E., Cobbold S.P., Davies J.D., Martin G.M., Phillips J.M., Waldmann H. Tolerance and suppression in a primed immune system. Transplantation. 62:1996;1614-1621.
34. Soares L.R., Orr P.L., Garovoy M.R., Benichou G. Differential activation of T cells by natural antigen peptide analogues: influence on autoimmune and alloimmune in vivo T cell responses. J. Immunol. 160:1998;4768-4775.
35. Bot A., Smith D., Bot S., Hughes A., Wolfe T., Wang L., Woods C., von Herrath M. Plasmid vaccination with insulin b chain prevents autoimmune diabetes in nonobese diabetic mice. J. Immunol. 167:2001;2950-2955.