Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats

Vascular Pharmacology

Volumn 38, Issue 3, 2002, Pages 127-130

  Rao, V S N ^a   Santos, F A ^a   Silva, R M ^a   Teixiera, M G ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

Aminoguanidine; Melatonin; Nitric oxide synthase inhibition; Peroxynitrite; Streptozotocin induced hyperglycemia

Indexed keywords

7 NITROINDAZOLE; AMINOGUANIDINE; MELATONIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; STREPTOZOCIN;

ANIMAL MODEL; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; DRUG INHIBITION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; MALE; MEASUREMENT; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; GUANIDINES; INDAZOLES; INJECTIONS, INTRAPERITONEAL; MALE; MELATONIN; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 0036524570     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1537-1891(02)00212-4     Document Type: Article

References (31)

1. Abdel-Wahab M.H., Abdel-Allah A.R. Possible protective effect of melatonin and/or desferroxamine against streptozotocin-induced hyperglycemia in mice. Pharmacol. Res. 41:2000;533-537.
2. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparently hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitrite oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;1620-1624.
3. Bhattacharya G. On the protection against alloxan diabetes by hexoses. Science. 120:1954;841-843.
4. Delaney C.A., Eizirik D.L. Intracellular targets for nitric oxide toxicity to pancreatic β-cells. Braz. J. Med. Biol. Res. 29:1996;569-579.
5. Gilad E., Cuzzocrea S., Zingarelli B., Salzman A.L., Szabo C. Melatonin is a scavenger of peroxynitrite. Life Sci. 60:1997;PL169.
6. Haluzik M., Nedvidkova J., Skrha J. The influence of NO synthase inhibitor and free oxygen radical scavenger, methylene blue on streptozotocin-induced diabetes in rats. Physiol. Res. 47:1998;337-341.
7. Ihm S.H., Yoo H.J., Park S.W., Ihm J. Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats. Metab. Clin. Exp. 48:1999;1141-1145.
8. Junod A., Lambert A.E., Orci L., Pictet R., Gonet A.E., Renold A.E. Studies of the diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 126:1967;201-205.
9. Kaya H., Oral B., Ozguner F., Tahan V., Babar Y., Delibas N. The effect of melatonin application on lipid peroxidation during cyclophosphamide therapy in female rats. Zentralbl. Gynakol. 121:1999;499-502.
10. Kolb H., Kiesel U., Kroncke K.D., Kolb-Bachofen V. Suppression of low dose streptozotocin induced diabetes in mice by administration of a nitric oxide synthase inhibitor. Life Sci. 49:1991;PL213-PL217.
11. 2+ regulation in pancreatic acinar cells from acute streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 298:1996;299-306.
12. Konrad R.J., Janowski K.M., Kudlow J.E. Glucose and streptozotocin stimulate p135 O-glycosylation in pancreatic islets. Biochem. Biophys. Res. Commun. 267:2000;26-32.
13. Kroncke K.D., Fehsel K., Sommer A., Rodriguez M.L., Kolb-bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage. Biol. Chem. Hoppe-Seyler. 376:1995;179-185.
14. Laffranchi R., Gogvadze V., Richter C., Spinas G.A. Nitric oxide (nitrogen mitochondria). Biochem. Biophys. Res. Commun. 217:1995;584-591.
15. Matkovics B., Kotorman M., Sz Varga I., Quy Hai Do., Varga Cs. Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol. Hung. 85:1998;29-38.
16. Mohan I.K., Das U.N. Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus. Free Radical Biol. Med. 25:1998;757-765.
17. Montilla P., Vardgas J.F., Tunez I.F., Munez de Agueda M.C., Valdelvira M.E., Cabrera E.S. Oxidative stress in diabetic rats induced by streptozotocin: monoxide, NO stimulates insulin secretion by inducing calcium release from protective effects of melatonin. J. Pineal Res. 25:1998;94-100.
18. Nilsson B.O. Biological effects of aminoguanidine: an update. Inflammation Res. 48:1999;509-515.
19. Noda Y., Mori A., Liburdy R., Packer L. Melatonin and its precursors scavenge nitric oxide. J. Pineal Res. 27:1999;159-163.
20. Okatani Y., Wakatsuki A., Morioka N., Watanabe K. Melatonin inhibits the vasorelaxant action of peroxynitrite in human umbilical artery. J. Pineal Res. 27:1999;111-115.
21. Okhuwa T., Sato Y., Naoi M. Hydroxyl radical formation in diabetogenic rats induced by streptozotocin. Life Sci. 56:1995;1789-1798.
22. Peschke E., Faúteck J.D., Mushoff U., Schmidt F., Beckmann A., Peschke D. Evidence for a melatonin receptor within pancreatic islets in neonate rats: functional, autoradiographic, and molecular investigations. J. Pineal Res. 28:2000;156-164.
23. Rakieten N., Rakieten M.L., Nadkarni M.V. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother. Rep. 29:1963;91-98.
24. Reiter R.J., Melchiorri D., Seweryneck E., Poeggeler B., Barlow-Walden L., Chuang J., Ortiz G.G., Acuna-Castroviego D. A review of the evidence supporting melatonin's role as an antioxidant. J. Pineal Res. 18:1995;1-11.
25. Reiter R.J., Tan D.X., Qi W.B. Suppression of oxygen toxicity by melatonin. Chung Kuo Li Hsueh Pao. 19:1998;575-581.
26. Schein P.S., Cooney D.A., Memenamin M.G., Anderson T. Streptozotocin diabetes: further studies on the mechanism of depression of nicotinamide adenine dinucleotide concentrations in mouse pancreatic islets and liver. Biochem. Pharmacol. 22:1973;2625-2633.
27. Tanaka Y., Shimazu H., Sato N., Mori M., Shimomura Y. Involvement of spontaneous nitric oxide production in the diabetogenic action of streptozotocin. Pharmacology. 50:1995;69-73.
28. Tesoriere L., D'Arpa D., Conti S., Giaccone V., Pintaudi A.M., Livrea M.A. Melatonin protects human red blood cells from oxidative hemolysis: new insights into the radical-scavenging activity. J. Pineal Res. 27:1999;95-105.
29. Tjalve H., Wilander E., Johansson E. Distribution of labelled streptozotocin in mice: uptake and retention in pancreatic islets. J. Endocrinol. 69:1976;455-456.
30. Uchigata Y., Yamamoto H., Kawamura A., Okamoto H. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J. Biol. Chem. 257:1982;6084-6088.
31. Xie Q.W., Nathan C. The high-output nitric oxide pathway: role and regulation. J. Leukocyte Biol. 56:1994;576-582.