Altered intracellular Ca2+ regulation in pancreatic acinar cells from acute streptozotocin-induced diabetic rats

European Journal of Pharmacology

Volumn 298, Issue 3, 1996, Pages 299-306

  Komabayashi, Takao ^a   Sawada, Hiroyuki ^a   Izawa, Tetsuya ^b   Kogo, Hiroshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b UNIVERSITY OF ELECTRO COMMUNICATIONS   (Japan)

Author keywords

1,4,5 IP3 sensitive Ca2+; Ca2+ mobilization; Ca2+ refilling; Diabetic pancreas; Muscarinic receptor; Store

Indexed keywords

ATROPINE; CALCIUM; CALCIUM 45; CARBACHOL; CHOLECYSTOKININ OCTAPEPTIDE; GUANYLYLIMIDODIPHOSPHATE; INOSITOL 1,3,4 TRISPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE; METHYLSCOPOLAMINE; MUSCARINIC RECEPTOR; RADIOLIGAND; STREPTOZOCIN; CHOLINERGIC RECEPTOR BLOCKING AGENT; DIAGNOSTIC AGENT; INOSINE TRIPHOSPHATE; PHOSPHATIDYLINOSITOL; SCOPOLAMINE DERIVATIVE;

ACINAR CELL; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; LIGAND BINDING; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; ACUTE DISEASE; ANIMAL; CELL MEMBRANE PERMEABILITY; CYTOLOGY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; IN VITRO STUDY; METABOLISM; PANCREAS; PHYSIOLOGY; WISTAR RAT;

ACUTE DISEASE; ANIMALS; CALCIUM; CALCIUM RADIOISOTOPES; CELL MEMBRANE PERMEABILITY; DIABETES MELLITUS, EXPERIMENTAL; INOSINE TRIPHOSPHATE; MALE; N-METHYLSCOPOLAMINE; PANCREAS; PARASYMPATHOLYTICS; PHOSPHATIDYLINOSITOLS; RATS; RATS, WISTAR; RECEPTORS, MUSCARINIC; SCOPOLAMINE DERIVATIVES; SIGNAL TRANSDUCTION; SINCALIDE;

EID: 0029665808     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00796-2     Document Type: Article

References (34)

1. 2+ mobilization in rat parotid acinar cells, Biochim. Biophys. Acta 1055, 259.
2. Adler, G. and H.F. Kern, 1975, Regulation of exocrine pancreatic secretory process by insulin in vivo, Horm. Metab. Res. 7, 290.
3. Berridge, M.J., R.M. Dawson, C.P. Downes, J.P. Heslop and R.F. Irvine, 1983, Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides, Biochem. J. 212, 473.
4. i-2 hepatocytes, Biochem. J. 271, 365.
5. Chandrasekar, B. and M. Korc, 1991, Alteration of cholecystokinin-mediated phosphatidylinositol hydrolysis in pancreatic acini from insulin-deficient rats: evidence for defective G protein activation, Diabetes 40, 1282.
6. Domschke, W., F. Tympner, S.S. Domschke and L. Demling, 1975, Exocrine pancreatic function in juvenile diabetes, Dig. Dis. Sci. 20, 309.
7. Fasolato, C., M. Hoth and R. Penner, 1993, A GTP-dependent step in the activation mechanism of capacitative calcium influx, J. Biol. Chem. 268, 20737.
8. Fleming, N., L.E. Silwinski and D.N. Burke, 1989, G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland, Life Sci. 44, 1027.
9. 2+ mobilization during short-term heat exposure in rat parotid glands, Comp. Biochem. Physiol. 105C, 451.
10. 2+ indicators with greatly improved fluorenscence properties, J. Biol. Chem. 260, 3440.
11. Hulme, E.C., N.J.M. Birdsall, A.S.V. Burgen and P. Mehta, 1978, The binding of antagonists to brain muscarinic receptors, Mol. Pharmacol. 14, 737.
12. Inoguchi, T., P. Xia, M. Kunisaki, S. Higashi, E.P. Feener and G.L. King, 1994, Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues, Am. J. Physiol. 267, E369.
13. Izawa, T., S. Saitou, T. Mochizuki and T. Komabayashi, 1993, Lack of the stimulatory effect of guanine nucleotide on diacylglycerol generation in permeabilized adipocytes from diabetic rats, Res. Commun. Chem. Pathol. Pharmacol. 82, 307.
14. Komabayashi, T., J.S. McKinney and R.P. Rubin, 1990, Regulation by diacylglycerol of calcium-evoked amylase secretion from intact and permeabilized pancreatic acinar cells, Cell Calcium 11, 501.
15. Korc, M. and M.H. Schoni, 1988, Quin 2 and manganese define multiple alterations in cellular calcium homeostasis in diabetic rat pancreas, Diabetes 37, 13.
16. Latifpour, J., A. Gousse, S. Kondo, T. Morita and R.M. Weiss, 1989, Effects of experimental diabetes on biochemical and functional characteristics of bladder muscarinic receptors, J. Pharmacol. Exp. Ther. 248, 81.
17. 2+-ATPaSe activity in erythrocytes of non-insulin-dependent diabetic rats, Horm. Metab. Res. 22, 136.
18. McMillian, M.K., S.P. Soltoff, J.D. Lechleiter, L.C. Cantley and B.R. Talamo, 1988, Extracellular ATP increases free calcium in rat parotid acinar cells, Biochem. J. 255, 291.
19. 2+ influx into parotid acini, J. Biol. Chem. 265, 15010.
20. Mertz, L.M., V.J. Horn, B.J. Baum and I.S. Ambudkar, 1990b, Calcium entry in rat parotid acini: activation by carbachol and aluminum fluoride, Am. J. Physiol. 258, C654.
21. +-ATPase in rat aorta, Diabetes 40, 1560.
22. Pandol, S.J. and M.S. Schoeffield-Payne, 1990, Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry in the pancreatic acinar cell, J. Biol. Chem. 265, 12846.
23. Shima, S., H. Fukase and N. Akamatsu, 1992, Adrenergic receptors and adenylate cyclase activity in hepatocytes of the streptozotocin-diabetic rat, Endocrinol. Jpn. 39, 157.
24. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate, Nature 306, 67.
25. Studer, R.K. and L. Ganas, 1989, Effect of diabetes on hormone-stimulated and basal hepatocyte calcium metabolism, Endocrinology 125, 2421.
26. 2+ transport activity in skeletal muscle of diabetic rats, Am. J. Physiol. 260, E626.
27. U'Prichard, D.C., T.D. Reisine, S. Yamamura, S.T. Mason, H.C. Fibiger, F. Ehlert and H.I. Yamamura, 1980, Differential super sensitivity of β-receptor subtypes in rat cortex and cerebellum after central noradrenergic denervation, Life Sci. 26, 355.
28. Vacca, J.B., W.J. Henke and W.A. Knight, Jr., 1964, The exocrine pancreas in diabetes mellitus, Ann. Intern. Med. 61, 242.
29. Vinayek, R., M. Murakami, C.N. Sharp, R.K. Jensen and J.D. Gardner, 1990, Carbachol desensitizes pancreatic enzyme secretion by down-regulation of receptors, Am. J. Physiol. 258, G107.
30. Watson, E.L. and K.L. Jacobson, 1986, Forskolin activation of adenylate cyclase in mouse parotid membranes, Life Sci. 39, 693.
31. 2+ release in permeabilized pancreatic acinar cells by hormonal and phorbol ester pretreatment, J. Biol. Chem. 264, 9762.
32. Williams, J.A. and G.T. Blevins, Jr., 1993, Cholecystokinin and regulation of pancreatic acinar cell function, Physiol. Rev. 73, 701.
33. Williams, R.S., T.F. Schaible, J. Scheuer and R. Kennedy, 1983, Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium, Diabetes 32, 881.
34. 2+], responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats, Am. J. Physiol. 266, H2334.