Knocking out xenograft rejection: Two reports on the knockout of one allele of the α1,3-galactosyltransferase gene in pigs bring us one step closer to the transplantation of pig organs into people

Nature Biotechnology

Volumn 20, Issue 3, 2002, Pages 231-232

  Platt, Jeffrey L ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTOSYLTRANSFERASE; N ACETYLLACTOSAMINIDE ALPHA 1,3 GALACTOSYLTRANSFERASE; N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE;

ALLELE; ANIMAL; GENETICS; HUMAN; NOTE; SWINE; TRANSGENIC ANIMAL; XENOGRAFT;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; GALACTOSYLTRANSFERASES; HUMANS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0036511140     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0302-231     Document Type: Article

References (14)

1. Evans, R.W. in Xenotransplantation (ed. J.L. Platt) 29–51 (ASM Press, Washington, DC, 2001).
2. Platt, J.L. Nature 392 (Suppl), 11–17 (1998).
3. Cascalho, M. & Platt, J.L. Immunity 14, 437–446 (2001).
4. Dai, Y. et al. Nat. Biotechnol. 20, 251–255 (2002).
5. Lai, L. et al. Science 295, 1089-1092 (2002).
6. Galili, U. & Swanson, K. Proc. Natl. Acad. Sci. USA 88, 7401–7404 (1991).
7. Jooste, S.V., Colvin, R.B. & Winn, H.J. J. Exp. Med. 154, 1332–1341 (1981).
8. Cooper, D.K.C. et al. J. Heart Transpl. 7, 238–246 (1988).
9. McCurry, K.R. et al. Nat. Med. 1, 423–427 (1995).
10. Gleason, R.E. & Murray, J.E. Transplantation 5, 343–359 (1967).
11. Platt, J.L. et al. Immunol. Today 11, 450–456 (1990).
12. Tanemura, M., Yin, D., Chong, A.S. & Galili, U. J. Clin. Invest. 105, 301–310 (2000).
13. Dalmasso, A.P., He, T., & Benson, B.A. Xenotransplantation 3, 54–62 (1996).
14. Lin, S.S. et al. Transpl. (Rapid Comm.) 70, 1667–1674 (2000).