Redox-operated genetic switches: The SoxR and OxyR transcription factors

Trends in Biotechnology

Volumn 19, Issue 3, 2001, Pages 109-114

  Pomposiello, Pablo J ^a   Demple, Bruce ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; DNA; HYDROGEN PEROXIDE; MESSENGER RNA; NITRIC OXIDE; POLYPEPTIDE; SUPEROXIDE; TRANSCRIPTION FACTOR;

BIOTECHNOLOGY; GENE ACTIVATION; GENE SWITCHING; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BIOTECHNOLOGY; DISULFIDES; DNA-BINDING PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FREE RADICALS; HYDROGEN PEROXIDE; NITRIC OXIDE; OXIDATION-REDUCTION; REPRESSOR PROTEINS; SUPEROXIDES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ESCHERICHIA COLI;

EID: 0035283587     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(00)01542-0     Document Type: Review

References (40)

1. Oxidative stress: Introduction
2. Adaptive Responses to Oxidative Stress: The soxRS and oxyR Regulons
3. Oxidative stress
4. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress
5. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli
6. soxR, a locus governing a superoxide response regulon in Escherichia coli K-12
7. Flavodoxin mutants of Escherichia coli K-12
8. Post-transcriptional repression of Escherichia coli OmpF protein in response to redox stress: Positive control of the micF antisense RNA by the soxRS locus
9. Molecular characterization of the soxRS genes of Escherichia coli: Two genes control a superoxide stress regulon
10. Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli
11. Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription
12. Overproduction and physical characterization of SoxR, a [2Fe-2S] protein that governs an oxidative response regulon in Escherichia coli
13. Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional activation
14. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein
15. The redox state of the [2Fe-2S] clusters in SoxR protein regulates its activity as a transcription factor
16. SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form
17. Spacing of promoter elements regulates the basal expression of the soxS gene and converts SoxR from a transcriptional activator into a repressor
18. DNA distortion mechanism for transcriptional activation by ZntR, a Zn(II)-responsive MerR homologue in Escherichia coli
19. In vivo kinetics of a redox-regulated transcriptional switch
20. Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of SoxR in vivo
21. Redox signal transduction: Mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form
22. Isolation of reductase for SoxR that governs an oxidative response regulon from Escherichia coli
23. Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon
24. Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages
25. Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages
26. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator
27. Inducible repair of oxidative DNA damage in Escherichia coli
28. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium
29. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins
30. Nitrosative stress: Activation of the transcription factor OxyR
31. A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator
32. Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli
33. The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding
34. The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein
35. Transcriptional regulator of oxidative stress-inducible genes: Direct activation by oxidation
36. Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection
37. Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth
38. Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli
39. Activation of the OxyR transcription factor by reversible disulfide bond formation
40. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status