CD3-ζchain expression of intratumoral lymphocytes is closely related to survival in gastric carcinoma patients

Cancer

Volumn 94, Issue 5, 2002, Pages 1437-1442

  Ishigami, Sumiya ^a   Natsugoe, Shoji ^a   Tokuda, Koki ^a   Nakajo, Akihiro ^a   Higashi, Hiroshi ^a   Iwashige, Hirohumi ^a   Aridome, Kuniaki ^a   Hokita, Shuichi ^a   Aikou, Takashi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

CD3 chain; Gastric carcinoma; Lymphocyte; Prognosis

Indexed keywords

CD3 ANTIGEN; PROTEIN SUBUNIT; CD3 ANTIGEN, ZETA CHAIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER IMMUNOLOGY; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GASTRECTOMY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CARCINOMA; T LYMPHOCYTE; BIOSYNTHESIS; CARCINOMA; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; PATHOLOGY; STOMACH TUMOR; SURVIVAL; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; CARCINOMA; DISEASE PROGRESSION; FEMALE; GASTRECTOMY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0036489222     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10346     Document Type: Article

References (26)

1. Gastric carcinoma with lymphoid stroma: Correlation to reactive hyperplasia in regional lymph nodes and prognosis
2. Lymphoid infiltration as a prognostic variable for early-onset breast carcinomas
3. Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer
4. The grading of rectal cancer: Historical perspectives and a multivariate analysis of 447 cases
5. Development of cancer immunotherapies based on identification of the genes encoding cancer regression antigens
6. Expression of CD3-zeta on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes
7. Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma
8. Genetic and mutational analysis of the T-cell antigen receptor
9. Alternations in signal transduction molecules in T lymphocytes from tumor bearing mice
10. CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs
11. Variable expression of CD3-zeta chain in tumor-infiltrating lymphocytes TIL derived from renal-cell carcinoma: Relationship with TIL phenotype and function
12. Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer
13. T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma
14. Alternation of signal-transducing molecules and phenotypical characteristics in peripheral blood lymphocytes from gastric carcinoma patients
15. Expression of signal transducing T-cell zeta molecules after adoptive immunotherapy in patients with gastric and colon cancer
16. Japanese classification of gastric carcinoma
17. Absent or low expression of the zeta chain in T cells at the tumor site correlates with poor survival in patients with oral carcinoma
18. Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles
19. Identification of HER2/neu-derived peptide epitopes recognized by gastric cancer-specific cytotoxic T lymphocyres
20. Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma
21. Decreased expression of the signal-transduction zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma
22. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses
23. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity
24. Alternation in T cell receptor and signal transduction molecules in melanoma patients
25. Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes
26. Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects