Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6985-6992

  Kawakami, Yutaka ^a,b   Robbins, Paul F ^b   Wang, Xiang ^b   Tupesis, Janis P ^b   Parkhurst, Maria R ^b   Kang, Xiaoqiang ^b   Sakaguchi, Kazuyasu ^c   Appella, Ettore ^c   Rosenberg, Steven A ^b,c  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2;

ALLELE; ANTIGEN RECOGNITION; ARTICLE; CELL SURFACE; DNA LIBRARY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOTHERAPY; MELANOMA; MELANOMA CELL; MELANOSOME; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGENS, NEOPLASM; CYSTEINE; DNA, COMPLEMENTARY; DNA, NEOPLASM; EPITOPES; FEMALE; HLA-A1 ANTIGEN; HLA-A2 ANTIGEN; HLA-A3 ANTIGEN; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MELANOMA; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0032534587     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Kawakami, Y., and S. A. Rosenberg. 1997. Human tumor antigens recognized by T-cells. Immunol. Res. 16:313.
2. Rosenberg, S. A., Y. Kawakami, P. F. Robbins, and R.-F. Wang. 1996. Identification of the genes encoding cancer antigens: implications for cancer immunotherapy. Adv. Cancer Res. 70:145.
3. Van Pel, A., P. van der Brugen, P. G. Coulie, V. G. Brichard, B. Lethe, B. van der Eynde, C. Uyttenhove, J.-C. Renauld, and B. Boon. 1995. Genes coding for tumor antigens recognized by cytolytic T lymphocytes. Immunol. Rev. 145:229.
4. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, L. Rivoltini, S. L. Topalian, T. Miki, and S. A. Rosenberg. 1994. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA 91:3515.
5. Bakker, A. B. H., M. W. J. Schreurs, A. J. de Boer, Y. Kawakami, S. A. Rosenberg, G. J. Adema, and C. G. Figdor. 1994. Melanocyte lineagespecific antigen gp100 is recognized by melanocyte-derived tumor-infiltrating lymphocytes. J. Exp. Med. 179:1005.
6. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P. F. Robbins, L. Rivoltini, J. B. Yannelli, E. Appella, and S. A. Rosenberg. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2 restricted tumor infiltrating lymphocytes. J. Exp. Med. 180:347.
7. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, K. Sakaguchi, E. Appella, J. R. Yannelli, G. J. Adema, T. Miki, and S. A. Rosenberg. 1994. Identification of a human melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad. Sci. USA 91:6458.
8. Kawakami, Y., S. Eliyahu, C. Jennings, K. Sakaguchi, X.-Q. Kang, S. Southwood, P. F. Robbins, A. Sette, E. Appella, and S. A. Rosenberg. 1995. Recognition of multiple epitopes in the human melanoma antigen gp100 associated with in vivo tumor regression. J. Immunol. 154:3961.
9. Robbins, P. F., M. El-Gamil, Y. Kawakami, E. Stevens, J. Yannelli, and S. A. Rosenberg. 1994. Recognition of tyrosinase by tumor infiltrating lymphocytes from a patient responding to immunotherapy. Cancer Res. 54:3124.
10. Kang, X.-Q., Y. Kawakami, K. Sakaguchi, M. El-Gamil, R.-F. Wang, J. R. Yannelli, E. Appella, S. A. Rosenberg, and P. F. Robbins. 1995. Identification of a tyrosinase epitope recognized by HLA-A24 restricted tumor-infiltrating lymphocytes. J. Immunol. 155:1343.
11. Wang, R.-F., M. Parkhurst, Y. Kawakami, P. F. Robbins, and S. A. Rosenberg. 1996. Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen. J. Exp. Med. 183:1131.
12. Wang, R. F., P. F. Robbins, Y. Kawakami, X.-Q. Kang, and S. A. Rosenberg. 1995. Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J. Exp. Med. 181:799.
13. Wang, R.-F., E. Appella, Y. Kawakami, X. Kang, and S. A. Rosenberg. 1996. Identification of TRP2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J. Exp. Med. 184:2207.
14. Wang, R.-F., S. L. Johnson, S. Southwood, A. Sette, and S. A. Rosenberg. 1998. Recognition of an antigenic peptide derived from tyrosinase-related protein-2 by CTL in the context of HLA-A31 and -A33. J. Immunol. 160:890.
15. Jager, E., M. Ringhoffer, J. Karbach, M. Arand, F. Oesch, and A. Knuth. 1996. Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo. Int. J. Cancer 66:470.
16. Rosenberg, S., J. Yang, D. Schwartzentruber, P. Hwu, F. Marincola, S. Topalian, N. Restifo, M. Dudley, S. Schwarz, P. Spiess, et al. 1998. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat. Med. 4:321.
17. Nestle, F., S. Alijagic, M. Gilliet, Y. Sun, S. Grabbe, R. Dummer, G. Burg, and D. Schadendorf. 1998. Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nat. Med. 4:328.
18. Kittlesen, D., L. W. Thompson, P. H. Gulden, J. C. A. Skipper, T. A. Colella, J. A. Shabanowitz, D. R. Hunt, V. H. Engelhard, and J. C. Slinglutf. 1998. Human melanoma patients recognize an HLA-A1-Restricted CTL epitope from tyrosinase containing two cysteine residues:implications for vaccine development. J. Immunol. 160:2099.
19. + cytotoxic T lymphocytes. J. Exp. Med. 181:363.
20. Tsai, V., S. Southwood, J. Sidney, K. Sakaguchi, Y. Kawakami, E. Appella, A. Sette, and E. Celis. 1997. Induction of subdominant CTL epitopes of the gp100 elanoma associated tumor antigen by primary in vitro immunization with peptide pulsed dendritic cells. J. Immunol. 158:1796.
21. Wolfel, T., A. Van Pel, V. Brichard, J. Schneider, B. Seliger, K.-H. Meyer Zum Buschenfelde, and T. Boon. 1994. Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur. J. Immunol. 24:759.
22. Skipper, J. C. A., D. J. Kittlesen, R. C. Hendrickson, D. D. Deacon, N. L. Harthun, S. N. Wagner, D. F. Hunt, V. H. Engelhard, and C. L. Slingluff. 1996. Shared epitopes for HLA-A3 restricted melanoma reactive human CTL include a naturally processed epitope from Pmel-17/gp100 J. Immunol 157: 5027.
23. Robbins, P. F., M. El-Gamil, Y. F. Li, E. Fitzgerald, Y. Kawakami, and S. A. Rosenberg. 1997. The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma reactive tumor infiltrating lymphocytes. J. Immunol., In press.
24. Brichard, V. G., J. Herman, A. Van Pel, C. Wildmann, B. Gaugler, T. Wolfel, T. Boon, and B. Lethe. 1996. A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes. Eur. J. Immunol. 26:224.
25. Schneider, J., V. Brichard, T. Boon, K. Buschenfelde, and T. Wolfel. 1998. Overlapping peptides of melanocyte differentiation antigen MERAN-A/MART-1 recognized by autologous cytolytic T lymphocytes in association with HLA-B45.1 and HLA-A2.1. Int. J. Cancer 75:451.
26. Topalian, S. L., M. I. Gonzales, M. Parkhurst, Y. F. Li, S. Southwood, A. Sette, S. A. Rosenberg, and P. F. Robbins. 1996. Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes. J. Exp. Med. 183: 1965.
27. Kawakami, Y., S. A. Rosenberg, and M. T. Lotze. 1988. Interleukin-4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma. J. Exp. Med. 168:2183.
28. Kawakami, Y., R. Zakut, S. L. Topalian, H. Stotter, and S. A. Rosenberg. 1992. Shared human melanoma antigens. Recognition by tumor infiltrating lymphocytes in HLA-A2.1 transfected melanomas. J. Immunol. 148:638.
29. Yannelli, J. R., C. Hyatt, S. McConnell, K. Hines, L. Jacknin, L. Parker, M. Sanders, and S. A. Rosenberg. 1996. Growth of tumor infiltrating lymphocytes from human solid cancers: summary of a 5 year experience. Int. J. Cancer 65:413.
30. Walter, E. A., P. D. Greenberg, M. J. Gilbert, R. J. Finch, K. S. Watanabe, E. D. Thomas, and S. R. Riddell. 1995. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N. Engl. J. Med. 333:1038.
31. Meadows, L., W. Wang, J. M. M. den Haan, J. W. Drijfhout, J. Shabanowitz, R. Pierce, A. I. Aguinik, C. E. Bishop, D. F. Hunt, E. Goulmy, and V. H. Engelhard. 1997. The HLA-A*0201 restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6:273.
32. Parkhurst, M., E. Fitzgerald, S. Southwood, A. Sette, S. A. Rosenberg, and Y. Kawakami. 1998. Identification of a shared HLA-A*0201 restricted T cell epitope from the melanoma antigen tyrosinase related protein 2 (TRP2). Cancer Res. 58:4895.
33. Kawakami, Y., N. Dang, X. Wang, J. Tupesis, P. F. Robbins, R. F. Wang, J. R. Wunderlich, J. R. Yannelli, and S. A. Rosenberg. 1998. Recognition of shared antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma. J. Immunother. In press.
34. Rosenberg, S. A., and D. E. White. 1996. Vitiligo in patients with melanoma: Normal tissue antigens can be targets for cancer immunotherapy. J. Immunother. 19:81.
35. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. Van Pel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, Jr., T. Boon, D. F. Hunt, and V. H. Engelhard. 1996. An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. J. Exp. Med. 183:527.
36. Bakker, A., M. Schreurs, G. Tafazzul, A. de Boer, Y. Kawakami, G. Adema, and C. Figdor. 1995. Identification of a novel peptide derived from the melanocytespecific gplOO antigen as the dominant epitope recognized by an HLA-A2. 1-restricted anti-melanoma CTL line. Int. J. Cancer 62:97.
37. Cox, A. L., J. Skipper, Y. Cehn, R. A. Henderson, T. L. Darrow, J. Shabanowitz, V. H. Engelhard, D. F. Hunt, and C. L. Slingluff. 1994. Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science 264: 716.
38. Tsai, V., S. Southwood, J. Disney, K. Sakaguchi, Y. Kawakami, E. Appella, A. Sette, and E. Celis. 1997. Induction of subdominant CTL epitopes of the gp100 melanoma associated tumor antigen by primary in vitro immunization with peptide pulsed dendritic cells. J. Immunol. 158:1796.