Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV-infected patients

Free Radical Biology and Medicine

Volumn 32, Issue 5, 2002, Pages 414-420

  Jaruga, Pawel ^a   Jaruga, Barbara ^a   Gackowski, Daniel ^a   Olczak, Anita ^a   Halota, Waldemar ^a   Pawlowska, Malgorzata ^a   Olinski, Ryszard ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

AIDS; Free radicals; IDUs; Oxidative DNA damage

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; DNA BASE; PLACEBO; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; DNA; RETINOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIPID PEROXIDATION; LYMPHOCYTE; MALE; MASS SPECTROMETRY; OXIDATIVE STRESS; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION; ADOLESCENT; BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DNA DAMAGE; DNA REPAIR; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; METABOLISM; OXIDATION REDUCTION REACTION; VIROLOGY;

ADOLESCENT; ADULT; ANTIOXIDANTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; ASCORBIC ACID; CASE-CONTROL STUDIES; CATALASE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPARATIVE STUDY; DIETARY SUPPLEMENTS; DNA; DNA DAMAGE; DNA REPAIR; FEMALE; HIV INFECTIONS; HUMAN; LIPID PEROXIDATION; LYMPHOCYTES; MALE; OXIDATION-REDUCTION; SPECTRUM ANALYSIS, MASS; SUPEROXIDE DISMUTASE; SUPPORT, NON-U.S. GOV'T; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN A; VITAMIN E; HUMANS; MASS SPECTROMETRY;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0036489188     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00821-8     Document Type: Article

References (43)

1. The role of oxidative stress in HIV disease
2. Oxidative DNA base damage in lymphocytes of HIV-infected drug users
3. Classification system for HIV infection and expended surveillance case definition for AIDS between adolescence and adults
4. Modification of DNA bases in mammalian chromatin by radiation-generated free radicals
5. Artificial background and induced levels of oxidative base damage in DNA from human cells
6. Endogenous oxidative DNA base modifications analysed with repair enzymes and GC/MS technique
7. Comparison of the levels of 8-hydroxyguanine in DNA as measured by gas chromatography mass spectrometry following hydrolysis of DNA by Escherichia coli Fpg protein or formic acid
8. The background level of 8-oxo-2′-deoxyguanosine in cellular DNA does not correlate with concentration of antioxidant vitamins in blood plasma
9. Colorimetric assay of catalase
10. Early superoxide dismutase alterations during SV40-transformation of human fibroblasts
11. Measurement of protein using bicinchoninic acid
12. Measurement of lipid-peroxidation - A comparison of different procedures
13. Measurement of lipid peroxidation: A review
14. High-performance liquid chromatography analysis of the thiobarbituric acid adducts of malonoaldehyde and trans-muconaldehyde
15. The role of oxidative imbalance in progression to AIDS: Effect of the thiol supplier N-acetylcysteine
16. Dietary oxidative stress and the potentiation of viral infection
17. The keys of oxidative stress in acquired immune deficiency syndrome apoptosis
18. Reactive oxygen species in living systems: Source, biochemistry and role in human disease
19. Superoxide enhances the spread of HIV-1 infection by cell-to-cell transmission
20. The role of 8-hydroxyguanine in carcinogenesis
21. Oxidative DNA-damage and cellular-sensitivity to oxidative stress in human autoimmune-diseases
22. Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in-vitro
23. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes
24. Vitamin C exhibits pro-oxidant properties
25. Novel repair action of vitamin C upon in vivo oxidative DNA damage
26. The effects of vitamin C supplementation on protein oxidation in healthy volunteers
27. Enzymatic processing of radiation-induced free radical damage in DNA
28. Mutagenicity and repair of oxidative DNA damage: Insight from studies using defined lesions
29. AIDS-associated cancers
30. DNA-base modifications in chromatin of human cancerous tissues
31. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer
32. Cell dysfunction and depletion in AIDS: The programmed cell death hypothesis
33. Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: Role of lymphocyte loss in HIV infection
34. Radiation induced apoptosis in a murine T-cell hybridoma
35. The role of intracellular oxidants in apoptosis
36. Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas
37. Oxidative stress in human immunodeficiency virus infection
38. A critical assessment of the prognostic value of HIV-1 RNA levels and CD4(+) cell counts in HIV-infected patients
39. Fluctuations in HIV-1 viral load are correlated to CD4(+) T-lymphocyte count during the natural course of infection
40. Though HIV is the main cause of AIDS, other factors play a role
41. Hormonal contraception, vitamin A deficiency, and other risk factors for shedding of HIV-1 infected cells from the cervix and vagina
42. Improved antioxidant status among HIV-infected injecting drug users on potent antiretroviral therapy