Protective effects of S-allylcysteine on hepatic glutathione and glutathione-dependent enzymes during hamster cheek pouch carcinogenesis

Journal of Biochemistry, Molecular Biology and Biophysics

Volumn 6, Issue 1, 2002, Pages 13-16

  Balasenthil, S ^a   Nagini, S ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; Chemoprevention; DMBA; Garlic; Glutathione; Lipid peroxidation

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; DIMETHYLBENZ[A]ANTHRACENE; ENZYME; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID; LIPID PEROXIDE; LIVER ENZYME; S ALLYLCYSTEINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PREVENTION; CANCER TISSUE; CARCINOGENESIS; CHEEK POUCH; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DYSPLASIA; ENZYME ACTIVITY; FACE CANCER; HISTOPATHOLOGY; HYPERPLASIA; LIPID PEROXIDATION; LIVER METABOLISM; MALE; NONHUMAN; PROTECTION; PROTEIN BLOOD LEVEL; SQUAMOUS CELL CARCINOMA; SYRIAN HAMSTER;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; CARCINOMA, SQUAMOUS CELL; CHEEK; CRICETINAE; CYSTEINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MESOCRICETUS; MOUTH NEOPLASMS; PROTECTIVE AGENTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ALLIUM SATIVUM; ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0036486744     PISSN: 10258140     EISSN: None     Source Type: Journal    
DOI: 10.1080/10258140290010160     Document Type: Article

References (35)

1. La Vecchia, C. and Tavani, A. (1998) "Fruit and vegetables, and human cancer", Eur. J. Cancer Prev. 7, 3-8.
2. Milner, J.A. (1996) "Garlic: its anticarcinogenic and antitumorigenic properties", Nutr. Rev. 54, S82-S86.
3. Gimenez-Conti, I.B. and Slaga, T.J. (1993) "The hamster cheek pouch carcinogenesis model", J. Cell Biochem. 17F, 83-90.
4. Chang, K.W., Sarraj, S., Lin, S.C., Tsai, P.I. and Solt, D. (2000) "p53 expression, p53 and Ha-ras mutation and telomerase activation during nitrosamine-mediated hamster pouch carcinogenesis", Carcinogenesis 21, 1441-1451.
5. Balasenthil, S., Saroja, M., Ramachandran, C.R. and Nagini, S. (2000) "Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione and glutathione dependent enzymes during oral carcinogenesis", Br. J. Oral Maxillofac. Surg. 38, 267-270.
6. Balasenthil, S., Arivazhagan, S. and Nagini, S. (1998) "Hepato-protective effects of garlic during hamster buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene", Med. Sci. Res. 26, 849-851.
7. Balasenthil, S., Arivazhagan, S., Ramachandran, C.R. and Nagini, S. (1999). "Effects of garlic on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis", Cancer Detect. Prev. 23. 534-538.
8. Balasenthil, S., Arivazhagan, S. and Nagini, S. (2000) "Garlic enhances circulatory antioxidants during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis", J. Ethnopharmacol. 72, 429-433.
9. Balasenthil, S., Ramachandran, C.R. and Nagini, S. (2001) "Garlic inhibits experimentally induced hamster buccal pouch carcinomas", J. Biochem. Mol. Biol. Biophys..
10. Balasenthil, S. and Nagini, S. (2000) "Inhibition of 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis by S-allylcysteine", Oral Oncol. 36, 382-386.
11. Herzfeld, A. and Greengard, O. (1972). "The dedifferentiated pattern of enzymes in livers of tumour-bearing rats", Cancer Res. 32, 1826-1832.
12. Nagini, S. and Nagarajan, B. (1986) "Hepatic ornithine transaminase is a potential tumor marker", Indian J. Clin. Biochem. 1, 1-7.
13. Nagini, S. and Nagarajan, B. (1988) "Hypolipidemic drug clofibrate induces hepatic dedifferentiation", Biochem. Int. 16, 127-137.
14. Nagini, S. and Manoharan, S. (1997) "Biomonitoring the chemopreventive potential of the plant products neem and turmeric in 4-nitroquinoline 1-oxide induced oral carcinogenesis", J. Clin. Biochem. Nutr. 23, 33-40.
15. Balasenthil, S., Arivazhagan, S. and Nagini, S. (1999) "Chemoprotective effects of neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis", J. Clin. Biochem. Nutr. 26, 9-15.
16. Arivazhagan, S., Balasenthil, S. and Nagini, S. (2000) "Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis", Phytother. Res. 14, 291-293.
17. Balasenthil, S. and Nagini, S. (2000) "Garlic exerts hepato-protective effects during 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats", Asia Pacific J. Clin. Nutr. 9, 136-138.
18. Balasenthil, S. and Nagini, S. (2000) "Enhancement of circulatory antioxidants by S-allylcysteine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis", J. Biochem. Mol. Biol. Biophys. 4, 35-39.
19. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction", Anal. Biochem. 95, 351-358.
20. Ellman, G.L. (1959) "Tissue sulfhydryl groups", Arch. Biochem. xBiophys. 82, 70-77.
21. Rotruck, J.T., Pope, A.L., Ganther, H.E., Swanson, A.B., Hafeman, D.G. and Hoekstra, W.G. (1973) "Selenium: Biochemical roles as a component of glutathione peroxidase", Science 179, 588-590.
22. Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974) "Glutathione S-transferases, the first step in mercapturic acid formation", J. Biol. Chem. 249, 7130-7139.
23. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) "Protein measurement with Folin phenol reagent", J. Biol. Chem. 193, 265-275.
24. Heidel, S.M., MacWilliams, P.S., Baird, W.M., Dashwood, W.M., Buters, J.T.M., Gonzalez, F.J., Larsen, M.C., Czuprynski, C.J. and Jefcoate, C.R. (2000) "Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene", Cancer Res. 60, 3454-3460.
25. Lu, S.C. (1999). "Regulation of hepatic glutathione synthesis: current concepts and controversies", FASEB J. 13, 1169-1173.
26. Eaton, J.W. (1991) "Catalase and peroxidase and glutathione and hydrogen peroxidase: mysteries of the bestiary", J. Lab. Clin. Med. 118, 3-4.
27. Coles, B. and Ketterer, B. (1990) "The role of glutathione and glutathione transferases in chemical carcinogenesis", Crit. Rev. Biochem. Mol. Biol. 25, 47-70.
28. Younes, M. and Siegers, C.P. (1980) "Lipid peroxidation as a consequence of glutathione depletion in rat and mouse liver", Res. Commun. Chem. Pathol. Pharmacol. 27, 119-128.
29. Johnson, I.T. (1997) "Plant anticarcinogens", Eur. J. Cancer. Prev. 6, 515-517.
30. Yamasaki, T., Li, L. and Lau, B.H.S. (1994) "Garlic compounds protect vascular endothelial cells from hydrogen peroxide-induced injury", Phytother. Res. 8, 408-412.
31. Hatono, S., Jimenez, A. and Wargovich, M.J. (1996) "Chemopreventive effect of S-allylcysteine and its relationship to the detoxification enzyme glutathione-S-transferase", Carcinogenesis 17, 1041-1044.
32. Pinto, J.T., Qiao, C., Xing, J., Rivlin, R.S., Protomastro, M.L., Weissler, M.L., Tao, Y., Thaler, H. and Heston, W.D.W. (1997) "Effects of garlic thioallyl derivatives on growth, glutathione concentration and polyamine formation of human prostate carcinoma cells in culture", Am. J. Clin. Nutr. 66, 398-405.
33. Nakagawa, S., Kasuga, S. and Matsuura, H. (1989) "Prevention of liver damage by aged garlic extract and its components in mice", Phytother. Res. 3, 50-53.
34. Mostafa, M.G., Mima, T., Ohnishi, S.T. and Mori, K. (2000) "S-allylcysteine ameliorates doxorubicin toxicity in the heart and liver in mice", Planta Med. 60, 148-151.
35. Ide, N. and Lau, B.H.S. (1997) "Garlic compounds protect vascular endothelial cells from oxidised low density lipoprotein-induced injury", J. Pharm. Pharmacol. 49, 908-911.