Mesenchyme to epithelium transition during development of the mammalian kidney tubule

Cells Tissues Organs

Volumn 156, Issue 3, 1996, Pages 187-201

  Davies, J A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Differentiation; Epitheliogenesis; Kidney; Mesenchyme epithelium transition; Nephron

Indexed keywords

CELL DIFFERENTIATION; EMBRYO; KIDNEY DEVELOPMENT; KIDNEY TUBULE; KIDNEY TUBULE EPITHELIUM; MAMMAL; MESENCHYME; NEPHROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; EMBRYONIC INDUCTION; EPITHELIAL CELLS; EPITHELIUM; HUMANS; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES; MESODERM; MORPHOGENESIS; STEM CELLS; WILMS TUMOR;

EID: 0030452985     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000147846     Document Type: Article

References (125)

1. Armstrong, J.P., K. Pritchard-Jones, W. Bickmore, N.D. Haslie, J.B. Bard (1993) The expression of the Wilms tumour gene. U7I, in the developing mammalian embryo. Mech Dev 40; 81-97.
2. Auerbach, R., C. Grobstcin (1958) Inductive interaction of embryonic tissues after dissociation and reaggregation. Exp Cell Res 15; 384-392.
3. Aufderheide, F., R. Chituct-Ehrisstnan, P. Ekblotn (1987) Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J Cell Biol 105; 599-608.
4. Baccarini, P., M. Fiorentino, A. D'Errico, A.M. Mancini, W.F. Grigioni (1993) Detection of antisense transcripts of the insulin-like growth factor 2 gene in Wilms tumor. Am J Pathol 145 1535-1542.
5. Bard, J.B.L. (1992) The development of the mouse kidney; Embryogenesis writ small. Curr Opin Genet Dev 2; 589-595.
6. Bard, J.B.L., J.E. McConnell, J.A. Davies (1994) Towards a genetic basis for kidney development. Mech Dev 48;.3-11.
7. Bard, I.B.I., A. Ross (1991) IF the ES-ccll inhibition factor, reversibly blocks nephrogenesis in cultures mouse kidney rudiments. Development 113; 193-198.
8. Birch, N. (1991) Lithium and the Cell. New York. Academic Press.
9. Blaekmore, M., E. Doherty, J.E. Manning, B.H. Hirst (1994) Autocrine stimulation of human renal Wilms tumor G401 cells by a gastrin-like peptide. Int J Cancer 57; 385-391.
10. Boulton, T.G., N. Stahl, G.D. Yancopoulos (1994) Ciliary neurotrophic faclor/leukaemia inhibitory factor/interleukin boncostatin M family of cytokines induce tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 269, Iss I; 1648-11655.
11. Burrow, C.R., P.D. Wilson (1993) A putative Wilms Tumour-secreted growth factor activity required for primary culture of human neph-roblasts. Proc Nall Acad Sei USA 90; 6066-6090.
12. Cardia, A.F, J. Hu, J. Crosby, P.A. Lalley, D. Noden, J.H. Nadeau, C.V. Wright (1992) Mox-I anil Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116; 1123-1136.
13. Coppes, M.J., B.R. Williams (1994) The molecular genetics of Wilms' tumor. Cancer Invest 12; 57-65.
14. Cremer, H., R. Lange, A. Christoph, M. Plomann, G. Vopper, J. Roes, R. Brown, S. Baldwin, P. Kearmer, S. Scheff, D. Barthels, K. Rajewsky, W. Willc (1994) Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and defects bulb and defects in spatial learning. Nature 367;455-458.
15. Davies, J.A. (1993) How to build a kidney. Semin Cell Biol 4;213-219.
16. Davies, J.A. (1994) Control of Calbindin D-28K expression in developing mouse kidney. Dev Dynam 199;45-51.
17. Davies, J.A., A.W. Brandli (1996) The Kidney Development Database. World Wide Web address http://mbisg2.sbe.man.ac.uk/kidbase/kidhome/html.
18. Davies, J.A., D.R. Garrod (1995) Induction of early stages of kidney tubule differentiation by lithium ions. Dev Biol 167; 50-60.
19. Davies, J.A., M. Lyon, J. Gallagher, D.R.G. Garrod (1995) Sulphatcd proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development. Development 121; 1507-1517.
20. Davis, S., T.H. Aldrich, N. Stahl, L. Pan, T. Taga, T. Kishimoto, N.Y. Ip, G.D. Yancopoulos (1993) LIFR beat and gp 130 as hcterodimeriz.ing signal transducers of the tripartite CNTF receptor. Science 360;1805-1808.
21. Dorup, J., A.B. Maunsbach (1982) The ultrastruc-tural development of distal nephron segments in the human fetal kidney. Anal Embryol 164 19-41.
22. Dressier, G.R. (1994) Developmental regulation and oncogenesis in the kidney. In Liotta LA (chairman); Molecular Genetics of Tumour Progression and Metastasis; A Special Conference of the American Association for Cancer Research.
23. Dressier, G.R., E.C. Douglas (1992) Pax2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sei USA 89; 1179-1183.
24. Dressier, G.R., U.W. Rothenpielcr, L.T. Patterson, L. Williams-Simons, H. Westphal (1992) Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature 362;65-67.
25. Drummond, I.A., S.I. Madden, P. Rohuer-Nutter, G.I. Bell, V.P. Sukhatme, F.J. Rauscher. III (1992) Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WTI. Science 257; 674-678.
26. Duband, H.I., S. Dufour, K. Hatla, M. Takcichi, G.M. Edelman, J.P. Thiery (1987) Adhesion molecules during somitogenesis in the avian embryo. J Cell Biol 104; 1361-1374.
27. Dunhill, M.S., W. Haley (1972) Some observations on ti e quantitative anatomy of the kidney. J Pathol 110; 113-121.
28. Durbecj, M., S. Sbdcrstrbm, T. Ebendal, C. Birch-nteicr, P. Ekblom (1993) Differential expression of neurotrophin receptors during renal development. Development 119;977-989.
29. Ekblom, P., M. Ekblom, L. Fecher, G. Kelin, H.-Y. Zhang, Y. Kaebuya, M.-L. Chu, V. Mayer, R. Timpl (1994) Role of mesenchymal nidogen for epithelial morphogenesis in vitro. Development 120; 1997-2002.
30. Ekblom, P., G. Klein, M. Ekblom, L. Sorokin (1991) Laminin isoforms and their receptors in the developing kidney. Am J Kid Dis 17; 603-605.
31. Ekblom, P., G. Klein, M. Ekblom, L. Sorokin (1991) Laminin isofonns and their receptors in the developing kidney. Am J Kid Dis 17; 603-605.
32. Ekblom, P., I. Thesleff, A. Miettincn, L. Saxen (1981) Organogenesis in a defined medium supplemented with transferrin. Cell Different 10;281-288.
33. Ekblom, I., I. Thesleff, L. Saxen, A. Miettincn, R. Timpl (1983) Transferrin as a foetal growth factor; Acquisition of responsiveness related to embryonic induction. Proc Natl Acad Sci USA 80; 2651-2655.
34. Erselius, J.R., M.D. Colliding, P. Gruss (1990) Structure and expression pattern of the murine Hox 3.2 gene. Development 110;629-642.
35. Fleming, S., D.B. Jones (1987) Immunocytochemi-eal evidence for transferrin-dependent proliferation during renal tubulogenesis. J Anal 153; 191-201.
36. Fransson, L.A., B. Havntark (1982) Structural requirement for heparan sulphate self association. Carbohyd Res 11; 135-144.
37. Gallagher, J.T. (1994) Heparan sulphates as membrane receptors for the fibroblast growth factors. Eur J Clin Client Clin Biochem 1; 1201-1208.
38. Garrod, D.R., S. Fleming (1990) Early expression of desmosomal components during kidney tubule morphogenesis in human and murine embryos. Development 108; 313-321.
39. Garvin, A.J., G.G. Re, B.I. Tamowski, D.J. Hazcn-Martin, D A Sens (1993) The G40I cell line, utilized for studies of chromosomal changes in Wilms tumor, is derived from rhabdoid tumour of the kidney. Am J Pathol 142; 375-380.
40. Gashler, A.L., D.T. Bonthron, S.L. Madden, F.J. Rauscher, III, T. Collins, V.P. Sukhatme (1992) Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1. Proc Natl Acad Sci USA 89;10941-10988.
41. Gaunt, S.J. (1987) Homocobox gene llox 1.5 expression in mouse embryos; Earliest detection by in situ hybridisation is during gaslrulation. Development 101;51-60.
42. Gaunt, S.J. (1988) Mouse homocobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs; A comparison of Hox 3.1 and Hox 1.5. Development 103; 135-144.
43. Gessler, M., A. Poustka, W. Cavanee, R.L. Neve, S.H. Orkin, G.A. Bruns (1990) Homozygous deletion in Wilms tumours of a zinc finger gene identified by chromosome jumping. Nature 343; 774-778.
44. Gherardi, E., M. Sharpe, K. Lane, A. Sirulnik, M. Stoker(l993) Hepalocytc growth factor/scatter factor (IIGF/SF). the c-met receptor and the behaviour of epithelial cells. Symp Six' F.xp Biol 47; 163-181.
45. Grobstein, C. (1953) Inductive cpithelio-mes-enchymal interactions in cultured organ rudiments of the mouse. Science 118;52-55.
46. Grobstein, C. (1955) Inductive interactions in the development of the mouse metanephros. J Exp Zool 130;319-340.
47. I Jabcr, D.A., D.E. Housman (1992) The genetics of Wilms tumor. Adv Cancer Res 5V 41-68.
48. Herzlinger, D., R. Abramson, H. Cohen (1993) Phenotypic conversions in renal development. J Cell Sci (suppl) 17;61-64.
49. Holland, P.N., B.L. Hogan (1988) Spatially restricted patterns of expression of the homo-ebox-conlaining gene Hox 2.1 during mouse embryogencsis. Development 102; 159-174.
50. Holthofer, H., A. Miettinen, V.P. Lehto, E. Lethonen, I. Virtanen (1984) Expression of vimentin and cylokeralin tvx's of intermediate filament proteins in developing and adult human kidneys. Lab Invest 50;552-559.
51. Kamvar, Y.S., J. Wada (1994) Insulin-like growth factor I receptor in metanephric development. Contrib Nephrol. Basel. Karger, vol 107, pp 168-173.
52. Karp, S.l., A. Oritz-Arduan, S. Li, E.G. Neilson (1994) Epithelial differentiation of metanephric mesenchymal cells after stimulation with hepatocylc growth factor or embryonic spinal cord. Proc Natl Acad Sci USA 91;5286-5290.
53. Kim, E.G., M.E. Choi, B.J. Ballermann (1994) Spatially restricted expression of SET mRMA in developing rat kidney. Am J Physiol 260; F135-161.
54. Kissane, J.M. (1983) Congenital malformations; in Heptinstall E (ed); Pathology of the Kidney. ed 3. London. Churchill Livingstone, pp 83-140.
55. Klein, G., M. Ekblom, L. Feeher, R. Timpl, P. Ekblom (1990) Differential expression of laminin A and B chains during development of embryonic mouse organs. Development 110; 823-837.
56. Klein, G., M. Langegger, R. Timpl, P. Ekblom (1988) Role of laminin A chain in the development of epithelial cell polarity. Cell 55; 331-341.
57. Klein, G., M. Langegger, C. Goridis, P. Ekblom (1988) Neural cell adhesion molecule during induction and development of the kidney. Development 102; 749-761.
58. Koch, W.G., C. Grobstein (1963) Transmission of radioisotopically labelled materials during embryonic induction in vitro. Dev Biol 7; 303-323.
59. Koda, J.E., A. Rapraeger, M. Bemfield (1985) Heparan sulphate proteoglucans from mouse mammary epithelial cells; cell surface proteoglycan as a receptor for interstitial collagens. J Biol Chem 260; 8157-8162.
60. Korhonen, M., I. Laitenen, I. Ylanne, V.S. Gould, I. Virtanen (1992) Inlegrins in developing, normal and pathological human kidney. Kidney lilt 41; 641-644.
61. Korhonen, M., J. Ylanne, L. Laitinen, I. Virtanen (1990) The al-«6 subunits of inlegrins are characteristically expressed in distinct segments of developing and adult human nephron. J Cell Biol 111; 1245-1254.
62. Koseki, D. Herzlinger, Q. Al-Awqati (1992) Apoptosis in metanephric development. J Cell Biol 119; 1327-1333.
63. Kushner, I., A. Cozzolino, J. Sherman, M.A. Rich (1992) Expression of a Wilms tumour gene in porcine kidney during compensatory renal growth. J Crol 148; 555-558.
64. Landshulz, W., I. Thesleff, P. Ekblom (1984) A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. J Cell Biol 98;596-601.
65. Lazzaro, LX, V. DeSimone, L. DcMagistris, E. Leh-tonen, R. Cortese (1992) LFB1 and LFB3 homeoproleins are sequentially expressed during kidney development. Development 114 469-479.
66. LeDouarin, N.M., M.-A.M. Teillet (1974) Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives using a biological cell marking technique. Dev Biol 41; 162-184.
67. Lee, K.F., E. Li, L.J. Huber, S.C. Landis, A.H. Sharpe, M.V. Chao, R. Jacnisch (1992) Targeted disruption of the gene encoding the low affinity NGF receptor p75 leads to defects in the peripheral sensory nervous system. Cell 69; 737-749.
68. Lchtonen, E. (1976) Transmission of signals in embryonic kidney. Med Biol 54;108-128.
69. Lemoine, N.R., C.M. Hughes, J.K. Cowell (1992) Aberrant expression of the tumour suppressor gene p53 is verv frequent in Wilms tumor. J Pathol 168;237-242.
70. Liu, Z.Z., J. Wada, K. Alvares, A. Kumar, E.l. Wallner, Y.S. Kanwar (1993) Distribution and relevance of insulin-like growth factor I receptor in metanephric development. Kidney hit 44; 1242-1250.
71. Lombard, M.-N., C. Grobstein (1969) Activity in various embryonic and postembryome sources for induction of kidney tubules. Dev Biol 19; 41-51.
72. Lyon, M., J.A. Deakin, K. Mizumo, T. Nakamura, J.L. Gallagher (1994) Interaction of hepatocyte growth factor with heparan sulphate. J Biol Chem 269;11216-11223.
73. Masu, Y., E. Wolf, B. Hollmann, M. Sendtner, G. Brem, H. Thoenen (1993) Disruption of the CNTF gene results in motor neuron degeneration. Nature 165;27-32.
74. Matsell, J. (1993) Abstract. J Am Soc Nephrol 4; 471.
75. McConnell, J.E., J.F. Armstrong, P.E. Hixlgcs, J.B.L. Bard (1995) Expression of 14-3-3 epsilon during metanephric development. Dev Biol 169; 218-228.
76. McMahon, A.P., A. Bradley (1990) The Will-1 (int i) proto-oncogene is required for the development of a large region of the mouse brain. Cell 62; 1073-1085.
77. Miura, M., A. Wanaka, M. Tokyama, K. Tanaka (1993) MFI I-1. a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett 326; 171-176.
78. Mugrauer, G., P. Ekblom (1991) Contrasting expression patterns of 3 members of the myc family of protooncogenes in the developing and adult mouse kidney. J Cell Biol 112; 13-25.
79. Muramalsu. IL, H. Shirakama, S. Yonezawa, H. Murata, T. Muramalsu (1993) Midkine, a retinoic acid-inducible growth lactor/differen-tiation factor; Immunochemical evidence for the function and distribution. Dev Biol 159; 392-402.
80. Nisen, P.D., K.A. Zimmerman, S.V. Colter, F. Gilbert, F.W. All (1986) Enhanced expression of the N-myc gene in Wilms' tumors. Cancer Res 46;6217-6222.
81. Orr-Urtrcger, A., D. Givol, A. Yayon, P. Lonai (1991) Developmental expression of two murine fibroblast growth factor receptors, tig andbek. Development 113; 1419-1434.
82. Phelps, D.K., G.R. Dressier (1993) Aberrant expression of Pax-2 in Danforth's short tail (Sd) mice. Dev Biol 157;251-268.
83. Polcev, A., H. Fickenscher, S. Mundlos, A. Win-terpacht, B. Zabel, A. Fidler, P. Gruss, D. Pla-chov (1992) Pax 8. a human paired box gene; Isolation and expression in developing thyroid, kidney and Wiim's tumours. Development 116; 611-623.
84. Prieto, A.L., K.L. Crossin (1995) Cell-cell adhesion molecule in epithelial-mesenchymal transformations. Acta Anal 154;21-33.
85. Rapraeger, A.C., A. Krufka, B.B. Olwin (1991) Requirement for heparan sulphate for hFGF mediated fibroblast growth and myoblast differentiation. Science 252; 1705-1708.
86. Rivcra-Madrid, R., P. Marinko, Y. Chartier, Y. Meyer (1993) Nucleotide sequence of an Ara-bidopsis rlwliana cDNA clone encoding a homolog to a suppressor of Wilms' tumour. Plant Physiol 102; 329-330.
87. Rothenpieler, U.W., G.R. Dressier (1993) Pax-2 is required for mesenchyine-to-cpithelium conversion during kidney development. Development 119;711-720.
88. Rutishauscr, U. (1992) NCAM and its polysialic acid moiety; a mechanism for puli/push regulation of cell interactions during development. Development suppl 1 1992 1;99-104.
89. Salmivirta, M., K. Elenius, S. Vainio, U. Hofer, R. Chiquet-Ehrissman, I. Thesleff, M. ialkanen (1991) Syndecan from tooth mesenchyme binds tenascin. J Biol Client 266;7733-7739.
90. Santos, O.F.P., E.J.G. Baros, X.M. Yang, K. Mal-sumoto, T. Nakamura, M. Park, S.K. Nigam (1994) Involvement of hepatoeyte growth factor in kidney development. Dev Biol 168; 525-529.
91. Sariola, H., K. Holm, S. Henke-Fahle (1988) Early innervation of the metancphric kidney. Development 104;589-599.
92. Sariola, H., M. Saanna, K. Sainio, U. Arumlie, J. Palgi, A. Vaahtokari, I. Thesleff, A. Karavanov (1991) Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. Science 254; 571-573.
93. Saunders, S., M. Bernfield (1988) Cell surface proteoglycan hinds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix. J Cell Biol 106; 423-430.
94. Saxen, L. (1970) Failure to demonstrate tubule induction in a heterologous mesenchyme. Dev Biol 23;511-523.
95. Saxen, L., (1980) Mechanism of morphogenetic tissue interactions; The message of transfilter experiments; in McKinnell RG. MA DiBerar-dino. M Blumcnficld. RD Bergad (eds); Results and Problems in Cell Differentiation, Vol II; Differentiation and Neoplasia. Berlin. Springer, pp 147-154.
96. Saxen, L., (1987) Organogenesis of the Kidney. Cambridge, Cambridge University Press.
97. Saxen, L., E. Lehtonen (1978) Transfilter induction of kidney tubules as a function of the extent and duration of intercellular contacts. J Embryol Exp Morphol 47;97-109.
98. Saxen, L., F-. Lehtonen, M. Karkincn-Jauskelainen, A. Nordling, I. Wartiovaara (1976) Are morphogenetic tissue interactions mediated by transmissible signal substances or through eell contacts? Nature 259;662-663.
99. Saxen, L., J. Salonen, P. Ekblom, S. Norling (1983) DNA synthesis and cell generation cycle during determination and differentiation of the metancphric mesenchyme. Dev Biol 98; 130-138.
100. Schmid, P., A. Lorenz, H. Hameister, M. Monte-narh (1991) Expression of p53 during mouse embryogenesis. Development 115;857-865.
101. Schuchardl, A., V. D'Agati, L. Larsson-Blomberg, F. Constantini, V. Pachnis (1994) Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 567;380-383.
102. Sharpe, P.T., J.R. Miller, F.P. Evans, M.D. Burtcnshaw, S.J. Gaunt (1988) Isolation and expression of a new mouse homoeobox gene. Development 102; 397-407.
103. Simpson, P., M. Bourouis, P Heilcler, L. Rule, M. Haenlin, P. Ramain (1992) Delta, notch and shaggy; Elements of a lateral signalling pathway in Dmsopliila. Cold Spring Harbor Symp Quant Biol 57;391-400.
104. Slack, J.M. (1993) Embryonic induction. Mech Dev 41;91-107.
105. Sonnenberg, E., D. Meyer, K.M. Weidner, C. Birchmeier (1993) Scatter I'actor/hepatocyte growth factor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelium during mouse development. J Cell Biol 123; 223-225.
106. Sorokin, L., A. Sonnenberg, M. Aumailley, R. Timpl, P. Ekblom (1990) Recognition of the laminin E8 cell-binding site by an integrin possessing the a6 subunit is essential for epithelial polarisation in developing kidney tubules. J Cell Biol 111; 1265-1273.
107. Staehlin, A. (1974) Structure and function of intercellular junctions. Lot Rev Cytol 39; 191-283.
108. Stanton, B.R., A.S. Perkins, L. Tessarollo, D.A. Sassoon, L.F. Parada (1992) Loss of N-mvr function results in embryonic lethality and failure of the epithelial compartment of the embryo to develop. Genes Dev 6; 2235-2247.
109. Stark, K., S. Vainio, G. Vassilcva, A.P. McMahon (1994) Epithelial transformation of meta-nephrie mesenchyme in the developing kidney regulated by Wm 4. Nature 372;679-683.
110. Thesleff, I., P Ekblom (1984) Role of transferrin in branching morphogenesis, growth and differentiation of the embryonic kidney. J Embryol Exp Morphol 82; 147-161.
111. Tsarlaly, I., S. Rong, J.ll. Resau, S. Ralong, PP. Da-Silva, G.F. Vande Woudc (1994) The met proto-oncogene mesenchymal to epithelial cell conversion. Science 263;98-101.
112. Tsutsui, J., K. Kadomatsu, S. Matsubara, A. Naka-gawara, M. Hamonoue, S. Takao, H. Shimazu, Y. Ohi, T. Muramatsu (1994) A new family of heparin-binding growth/differentiation factors; Increased midkine expression in Wilms tumor and other human carcinomas. Cancer Res 53; 1281-1285.
113. Uehara, K., S. Matsubara, K. Kadomatsu, J. Tsut-sui, T. Muramatsu (1992) Genomic structure of human midkine (MK). a retinoic acid-response growth/differentiation factor. J Biochem III; 563-567.
114. Unsworth, B., C. Grobstein (1970) Induction of kidney tubules in mouse metanephrogenic mesenchyme by various embryonic mesodermal tissues. Dev Biol 21;547-556.
115. Vcstwcbcr, D., R. Kernler, P. Ekblom (1985) Cell adhesion molecule uvomorulin during kidney development. Dev Biol 112; 213-221.
116. Wall, N.A., C.M. Jones, B.L. Hogan, C.V. Wright (1992) Expression and modification of Hox 2.1 protein in mouse embryos. Mech Dev 92; 111-120.
117. Wartiovaara, J., S. Nordling, E. Lehtonen, L. Saxen (1974) Transfilter induction of kidney tubules; Correlation with cytoplasmic penetration into Nuclaopore filters. J Embryol Exp Morphol 51; 667-682.
118. Weinmaster, G., V.J Roberts, G. Lemke (1991) A homolog of Drosophila Notch expressed during mammalian development. Development 113;199-205.
119. Weinmaster, G., V.J. Roberts, G. Lemke (1992) Notch2; A second mammalian Notch gene. Development 116;931-941.
120. Weller, A., L. Sorokin, E.M. Illgen, P. Ekblom (1991) Development and growth of mouse embryonic kidney in organ culture and modulation of development by soluble growth factor. Dev Biol 144; 248-261.
121. Werner, H., F.J. Rauscher, III, V.P. Sukhatmc, I.A. Drummond, C.T. Roberts, Jr., D. LeRoith (1994) Transcriptional repression of the insulin-like growth factor I receptor (lOFI-R) gene by the tumor suppressor WTI involves binding to sequences both upstream and downstream of the IGFI-R gene transcription start site. J Biol Chem 269; 12577-12582.
122. Weston, J.A. (1963) A radioaulographic analysis of the migration and localisation of trunk neural crest cells in the chick. Dev Biol 6; 279-310.
123. Wilkinson, D.G., J.A. Bailes, A.P. McMahon (1987) Expression of the protooncogenc ini-1 is restricted to specific neuronal cells in the developing mouse embryo. Cell 50;79-88.
124. Woolf, A.S., M. Kolatsi, P Hardman, E. Andcrma-chcr, C. Moorby, G. Fine, P.S. Jat, M.D. Noble, E. Gherardi (1994) Roles of hepatoeyte growth factor/scatter factor (HGF/SF) and the met receptor in the early development of the meta-nephros. J Cell Biol 128; 171-184.
125. Yun, K., A.T. Molenaar, A.M. Fiedler, A.J. Mark, M.R. Ecclcs, D.M. Becroft, A.E. Reeve (1993) Insulin-like growth factor II messenger RNA expression in Wilms tumour, nephrogenic rest and kidney. Lab Invest 69;603-615.