Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: Cholesterol acyltransferase (ACAT) inhibitor

Biochemical Pharmacology

Volumn 63, Issue 3, 2002, Pages 349-360

  Taghibiglou, Changiz ^a   Van Iderstine, Stephen C ^a   Kulinski, Agnes ^a   Rudy, Debbie ^a   Adeli, Khosrow ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

ACAT; Apolipoprotein B; Avasimibe; Cholesteryl ester; Degradation; Lipoproteins; Liver

Indexed keywords

APOLIPOPROTEIN B; AVASIMIBE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; MG 123; PROTEASOME INHIBITOR;

ARTICLE; CELL FRACTIONATION; CELL STRAIN HEPG2; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; INCUBATION TIME; LIPID ANALYSIS; LIPOPROTEIN SECRETION; LIPOPROTEIN SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN TRANSPORT;

ACETATES; APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; BIOLOGICAL TRANSPORT; CYSTEINE PROTEINASE INHIBITORS; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GOLGI APPARATUS; HUMANS; LEUPEPTINS; LIPID METABOLISM; OLEIC ACID; STEROL O-ACYLTRANSFERASE; SULFONIC ACIDS; TUMOR CELLS, CULTURED;

EID: 0036470894     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00918-2     Document Type: Article

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