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Volumn 79, Issue 2, 1999, Pages 151-158

Effects of NTE-122, a novel Acyl-CoA:Cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-Containing lipoprotein and bile acids in HepG2

Author keywords

Acyl CoA:cholesterol acyltransferase (ACAT) inhibitor; Apolipoprotein B containing lipoprotein secretion; Bile acid secretion; HepG2 cell; NTE 122

Indexed keywords

1,4 BIS[[1 CYCLOHEXYL 3 (4 DIMETHYLAMINOPHENYL)UREIDO]METHYL]CYCLOHEXANE; 2,2 DIMETHYL N (2,4,6 TRIMETHOXYPHENYL)DODECANAMIDE; 25 HYDROXYCHOLESTEROL; ACETIC ACID; ANTILIPEMIC AGENT; APOLIPOPROTEIN B; APOLIPOPROTEIN B100; BILE ACID; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; E 5324; LIPOPROTEIN; OLEIC ACID; PHOSPHOLIPID; PROBUCOL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 0033025573     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.151     Document Type: Article
Times cited : (9)

References (33)
  • 1
    • 0030943621 scopus 로고    scopus 로고
    • Acyl-coenzyme A:Cholesterol acyltransferase
    • Chang TY, Chang CCY and Cheng D: Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem 66, 613-638 (1997)
    • (1997) Annu Rev Biochem , vol.66 , pp. 613-638
    • Chang, T.Y.1    Chang, C.C.Y.2    Cheng, D.3
  • 2
    • 0026605381 scopus 로고
    • Regulation of hepatic secretion of very low density lipoprotein by dietary cholesterol
    • Fungwe TV, Cagen L, Wilcox HG and Heimberg M: Regulation of hepatic secretion of very low density lipoprotein by dietary cholesterol. J Lipid Res 33, 179-191 (1992)
    • (1992) J Lipid Res , vol.33 , pp. 179-191
    • Fungwe, T.V.1    Cagen, L.2    Wilcox, H.G.3    Heimberg, M.4
  • 3
    • 0019139290 scopus 로고
    • Secretion of very low density lipoproteins enriched on cholesterol esters by cultured rat hepatocytes during stimulation of intracellular cholesterol esterification
    • Drevon CA, Engehorn SC and Steinberg D: Secretion of very low density lipoproteins enriched on cholesterol esters by cultured rat hepatocytes during stimulation of intracellular cholesterol esterification. J Lipid Res 21, 1065-1071 (1980)
    • (1980) J Lipid Res , vol.21 , pp. 1065-1071
    • Drevon, C.A.1    Engehorn, S.C.2    Steinberg, D.3
  • 4
    • 0029248965 scopus 로고
    • Cardiovascular disease and hyperlipidemia
    • Miller JP: Cardiovascular disease and hyperlipidemia. Curr Opin Lipidol 6, U15-U19 (1995)
    • (1995) Curr Opin Lipidol , vol.6
    • Miller, J.P.1
  • 6
    • 0027531667 scopus 로고
    • Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: Information obtained from cultured liver cells
    • Dixon JL and Ginberg HN: Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells. J Lipid Res 34, 167-179 (1993)
    • (1993) J Lipid Res , vol.34 , pp. 167-179
    • Dixon, J.L.1    Ginberg, H.N.2
  • 8
    • 0028365288 scopus 로고
    • Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester
    • Wu X, Sakata N, Dixon J and Ginsberg HN: Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. J Biol Chem 269, 12375-12382 (1994)
    • (1994) J Biol Chem , vol.269 , pp. 12375-12382
    • Wu, X.1    Sakata, N.2    Dixon, J.3    Ginsberg, H.N.4
  • 9
    • 0023787966 scopus 로고
    • Regulation of apolipoprotein synthesis and secretion in the human hepatoma HepG2
    • Craig WY, Nutik R and Cooper AD: Regulation of apolipoprotein synthesis and secretion in the human hepatoma HepG2. J Biol Chem 263, 13880-13890 (1988)
    • (1988) J Biol Chem , vol.263 , pp. 13880-13890
    • Craig, W.Y.1    Nutik, R.2    Cooper, A.D.3
  • 10
    • 0026705766 scopus 로고
    • The effect of low density lipoproteins, cholesterol, and 25-hydroxycholesterol on apolipoprotein B gene expression in HepG2 cells
    • Dashti N: The effect of low density lipoproteins, cholesterol, and 25-hydroxycholesterol on apolipoprotein B gene expression in HepG2 cells. J Biol Chem 267, 7160-7169 (1992)
    • (1992) J Biol Chem , vol.267 , pp. 7160-7169
    • Dashti, N.1
  • 11
    • 0020049847 scopus 로고
    • Intrahepatic assembly of very low density lipoprotein. Competition by cholesterol ester for the hydrophobic core
    • Davis RA, McNeal MM and Moses RL: Intrahepatic assembly of very low density lipoprotein. Competition by cholesterol ester for the hydrophobic core. J Biol Chem 257, 2634-2640 (1982)
    • (1982) J Biol Chem , vol.257 , pp. 2634-2640
    • Davis, R.A.1    McNeal, M.M.2    Moses, R.L.3
  • 12
    • 0018745426 scopus 로고
    • Secretion of cholesterol-rich lipoproteins by perfused liver of hypercholesterolemic rats
    • Noel SP, Wong L, Dolphin PJ, Dory L and Rubenstein D: Secretion of cholesterol-rich lipoproteins by perfused liver of hypercholesterolemic rats. J Clin Invest 64, 674-683 (1979)
    • (1979) J Clin Invest , vol.64 , pp. 674-683
    • Noel, S.P.1    Wong, L.2    Dolphin, P.J.3    Dory, L.4    Rubenstein, D.5
  • 13
    • 0026495113 scopus 로고
    • Effect of the ACAT inhibitor CI-976 on plasma cholesterol concentrations and distribution in hamsters fed zero- and low-cholesterol diet
    • Krause BR, Bousely RF, Kieft KA and Stanfield RL: Effect of the ACAT inhibitor CI-976 on plasma cholesterol concentrations and distribution in hamsters fed zero- and low-cholesterol diet. Clin Biochem 25, 371-377 (1992)
    • (1992) Clin Biochem , vol.25 , pp. 371-377
    • Krause, B.R.1    Bousely, R.F.2    Kieft, K.A.3    Stanfield, R.L.4
  • 14
    • 0030059038 scopus 로고    scopus 로고
    • Inhibition of acyl-CoA:Cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells
    • Musanti R, Giorgini L, Lovisolo P, Pirillo A, Chiari A and Ghiselli G: Inhibition of acyl-CoA:cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells. J Lipid Res 37, 1-14 (1996)
    • (1996) J Lipid Res , vol.37 , pp. 1-14
    • Musanti, R.1    Giorgini, L.2    Lovisolo, P.3    Pirillo, A.4    Chiari, A.5    Ghiselli, G.6
  • 15
    • 0030581123 scopus 로고    scopus 로고
    • Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells
    • Graham A, Wood JL and Russell LJ: Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. Biochim Biophys Acta 1302, 46-54 (1996)
    • (1996) Biochim Biophys Acta , vol.1302 , pp. 46-54
    • Graham, A.1    Wood, J.L.2    Russell, L.J.3
  • 16
    • 0027501003 scopus 로고
    • Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
    • Dietschy JM, Turley SD and Spady DK: Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 34, 1637-1659 (1993)
    • (1993) J Lipid Res , vol.34 , pp. 1637-1659
    • Dietschy, J.M.1    Turley, S.D.2    Spady, D.K.3
  • 17
    • 0019445908 scopus 로고
    • Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis
    • Nestel PJ and Billington T: Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis. Atherosclerosis 38, 203-209 (1981)
    • (1981) Atherosclerosis , vol.38 , pp. 203-209
    • Nestel, P.J.1    Billington, T.2
  • 18
    • 0023652640 scopus 로고
    • The role of acyl-CoA:Cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes
    • Sampson WJ, Suffolk RA, Bowers P, Houghton JD, Botham KM and Suckling KE: The role of acyl-CoA:cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes. Biochim Biophys Acta 920, 1-8 (1987)
    • (1987) Biochim Biophys Acta , vol.920 , pp. 1-8
    • Sampson, W.J.1    Suffolk, R.A.2    Bowers, P.3    Houghton, J.D.4    Botham, K.M.5    Suckling, K.E.6
  • 20
    • 0030862598 scopus 로고    scopus 로고
    • ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): Stimulation of bile acid production by HL-004
    • Murakami S, Yamagishi I, Sato M, Tomisawa K, Nara Y and Yamori Y: ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004. Atherosclerosis 133, 97-104 (1997)
    • (1997) Atherosclerosis , vol.133 , pp. 97-104
    • Murakami, S.1    Yamagishi, I.2    Sato, M.3    Tomisawa, K.4    Nara, Y.5    Yamori, Y.6
  • 21
    • 0031761099 scopus 로고    scopus 로고
    • Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:Cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits
    • Azuma Y, Kawasaki T, Ikemoto I, Obata K, Ohno K, Sajiki N, Yamada T, Yamasaki M and Nobuhara Y: Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol 78, 355-364 (1998)
    • (1998) Jpn J Pharmacol , vol.78 , pp. 355-364
    • Azuma, Y.1    Kawasaki, T.2    Ikemoto, I.3    Obata, K.4    Ohno, K.5    Sajiki, N.6    Yamada, T.7    Yamasaki, M.8    Nobuhara, Y.9
  • 23
    • 0024998547 scopus 로고
    • Effect of Simvastatin (MK-733) on the regulation of cholesterol synthesis in HepG2 cells
    • Nagata Y, Hidaka Y, Ishida F and Kamei T: Effect of Simvastatin (MK-733) on the regulation of cholesterol synthesis in HepG2 cells. Biochem Pharmacol 40, 843-850 (1990)
    • (1990) Biochem Pharmacol , vol.40 , pp. 843-850
    • Nagata, Y.1    Hidaka, Y.2    Ishida, F.3    Kamei, T.4
  • 24
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG and Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911-917 (1959)
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 25
    • 0024311922 scopus 로고
    • Isolation and characterization of lipoproteins produced by human hepatoma-derived cell lines other than HepG2
    • Forte M, McCall RM, Knowles BB and Shore GV: Isolation and characterization of lipoproteins produced by human hepatoma-derived cell lines other than HepG2. J Lipid Res 30, 817-829 (1989)
    • (1989) J Lipid Res , vol.30 , pp. 817-829
    • Forte, M.1    McCall, R.M.2    Knowles, B.B.3    Shore, G.V.4
  • 27
    • 0025756150 scopus 로고
    • Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
    • Sliskovic DR and White AD: Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. Trends Pharmacol Sci 12, 194-199 (1991)
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 194-199
    • Sliskovic, D.R.1    White, A.D.2
  • 28
    • 0025667289 scopus 로고
    • Regulation of apoB secretion from HepG2 cells: Evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge
    • Cianflone KM, Yasruel Z, Rodriguez MA, Vas D and Sniderman AD: Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. J Lipid Res 31, 2045-2055 (1990)
    • (1990) J Lipid Res , vol.31 , pp. 2045-2055
    • Cianflone, K.M.1    Yasruel, Z.2    Rodriguez, M.A.3    Vas, D.4    Sniderman, A.D.5
  • 29
    • 0024363393 scopus 로고
    • The apolipoprotein B gene is constitutively expressed in HepG2 cells; regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life
    • Pullinger CR, North JD, Teng BB, Rifici VA, Ronhild de Brito AE and Scott J: The apolipoprotein B gene is constitutively expressed in HepG2 cells; regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life. J Lipid Res 30, 1065-1077 (1989)
    • (1989) J Lipid Res , vol.30 , pp. 1065-1077
    • Pullinger, C.R.1    North, J.D.2    Teng, B.B.3    Rifici, V.A.4    Ronhild De Brito, A.E.5    Scott, J.6
  • 30
    • 0029795221 scopus 로고    scopus 로고
    • ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools
    • Benoist F and Grand-Perret T: ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools. Arterioscler Thromb 16, 1229-1235 (1996)
    • (1996) Arterioscler Thromb , vol.16 , pp. 1229-1235
    • Benoist, F.1    Grand-Perret, T.2
  • 32
    • 0028179080 scopus 로고
    • ACAT inhibitor decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance
    • Kurause BR, Pape ME, Kieft K, Auerbach B, Bisgaier CL, Homan R and Newton RS: ACAT inhibitor decreases LDL cholesterol in rabbits fed a cholesterol-free diet. Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance. Arterioscler Thromb 14, 598-604 (1994)
    • (1994) Arterioscler Thromb , vol.14 , pp. 598-604
    • Kurause, B.R.1    Pape, M.E.2    Kieft, K.3    Auerbach, B.4    Bisgaier, C.L.5    Homan, R.6    Newton, R.S.7
  • 33
    • 0028964742 scopus 로고
    • Cell toxicity induced by inhibition of acyl coenzyme A:Cholesterol acyltransferase and accumulation of unesterified cholesterol
    • Warner GJ, Stoudt G, Bamberger M, Johnson W and Rothblat GH: Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol. J Biol Chem 270, 5772-5778 (1995)
    • (1995) J Biol Chem , vol.270 , pp. 5772-5778
    • Warner, G.J.1    Stoudt, G.2    Bamberger, M.3    Johnson, W.4    Rothblat, G.H.5


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