Factor Va-factor Xa interactions: Molecular sites involved in enzyme:cofactor assembly

Scandinavian Journal of Clinical and Laboratory Investigation, Supplement

Volumn 62, Issue 237, 2002, Pages 5-12

  Steen, M ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Coagulation; Factor IXa; Factor V; Factor VIII; Factor Xa; Phospholipids; Prothrombin; Thrombin

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9A; ENZYME; PHOSPHOLIPID; PROTHROMBIN; THROMBIN;

BINDING AFFINITY; BINDING SITE; BLOOD CLOTTING; CONFERENCE PAPER; DISSOCIATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

BINDING SITES; FACTOR VA; FACTOR XA; HUMANS;

EID: 0036460693     PISSN: 0085591X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (38)

1. Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: Initiation, maintenance, and regulation. Biochemistry 1991; 30; 10363-70.
2. Mann KG, Nesheim ME, Church WR, Haley P, Krishnaswamy S. Surface-dependent reactions of the vitamin K-dependent enzyme complexes. Blood 1990; 76; 1-16.
3. Kane WH, Davie EW. Blood coagulation factors V and VIII: Structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood 1988; 71; 539-55.
4. Jenny RJ, Tracy PB, Mann KG. The physiology and biochemistry of factor V. In: Bloom AL, Forbes CD, Thomas DP, Tuddenham EGD, editors. Haemostasis and Thrombosis, 3rd Ed. Edinburgh: Churchill Livingstone; 1994. p. 456-76
5. Nesheim ME, Taswell JB, Mann KG. The contribution of bovine Factor V and Factor Va to the activity of prothrombinase. J Biol Chem 1979; 254; 10952-62.
6. van Dieijen G, Tans G, Rosing J, Hemker HC. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem 1981; 256; 3433-42.
7. Dahlback B. Blood coagulation. Lancet 2000; 355; 1627-32.
8. Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem 1994; 269; 31869-80.
9. Harlos K, Martin DM, O'Brien DP, Jones EY, Stuart DI, Polikarpov I, Miller A, Tuddenham EG, Boys CW. Crystal structure of the extracellular region of human tissue factor. Nature 1994; 370; 662-6.
10. Bode W, Brandstetter H, Mather T, Stubbs MT. Comparative analysis of haemostatic proteinases: Structural aspects of thrombin, factor Xa, factor IXa and protein C. Thromb Haemost 1997; 78; 501-11.
11. Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 1996; 380; 41-6.
12. Villoutreix BO, Dahlback B. Structural investigation of the A domains of human blood coagulation factor V by molecular modeling. Protein Sci 1998; 7; 1317-25.
13. Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost 2000; 84; 849-57.
14. Monkovic DD, Tracy PB. Activation of human factor V by factor Xa and thrombin. Biochemistry 1990; 29; 1118-28.
15. Suzuki K, Dahlback B, Stenflo J. Thrombin-catalyzed activation of human coagulation factor V. J Biol Chem 1982; 257; 6556-64.
16. DiScipio RG, Hermadson MA, Yates SG, Davic DE. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor) and Protein S. Biochemistry 1977; 14; 698-706.
17. Steinberg M, Nemerson Y. Hemostasis and Thrombosis. Philadelphia: Lippincott; 1987.
18. McMullen BA, Fujikawa K, Kisiel W, Sasagawa T, Howald WN, Kwa EY, Weinstein B. Complete amino acid sequence of the light chain of human blood coagulation factor X: Evidence for identification of residue 63 as beta- hydroxyaspartic acid. Biochemistry 1983; 22; 2875-84.
19. Mertens K, Cupers R, Van Wijngaarden A, Bertina RM. Binding of human blood-coagulation Factors IXa and X to phospholipid membranes. Biochem J 1984; 223; 599-605.
20. Bloom JW, Nesheim ME, Mann KG. Phospholipid-binding properties of bovine factor V and factor Va. Biochemistry 1979; 18; 4419-25.
21. van de Waart P, Bruls H, Hemker HC, Lindhout T. Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles. Biochemistry 1983; 22; 2427-32.
22. Pusey ML, Nelsestuen GL. Membrane binding properties of blood coagulation Factor V and derived peptides. Biochemistry 1984; 23; 6202-10.
23. Lindhout T, Govers-Riemslag JW, van de Waart P, Hemker HC, Rosing J. Factor Va-factor Xa interaction. Effects of phospholipid vesicles of varying composition. Biochemistry 1982; 21; 5494-502.
24. Ortel TL, Quinn-Allen MA, Keller FG, Peterson JA, Larocca D, Kane WH. Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras. J Biol Chem 1994; 269; 15898-905.
25. Ortel TL. Clinical and laboratory manifestations of anti-factor V antibodies. J Lab Clin Med 1999; 133; 326-34.
26. Nicolaes GA, Villoutreix BO, Dahlback B. Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex. Blood Coagul Fibrinolysis 2000; 11; 89-100.
27. Bakker HM, Tans G, Thomassen MC, Yukelson LY, Ebberink R, Hemker HC, Rosing J. Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain. J Biol Chem 1994; 269; 20662-7.
28. Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270; 21158-66.
29. Camire RM, Kalafatis M, Tracy PB. Proteolysis of factor V by cathepsin G and elastase indicates that cleavage at Arg1545 optimizes cofactor function by facilitating factor Xa binding. Biochemistry 1998; 37; 11896-906.
30. Deguchi H, Takeya H, Gabazza EC, Nishioka J, Suzuki K. Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex. Biochem J 1997; 321; 729-35.
31. Boscovic DS, Giles AR, Nesheim ME. Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid. J Biol Chem 1990; 265; 10497-505.
32. Kotkow KJ, Deitcher SR, Furie B, Furie BC. The second kringle domain of prothrombin promotes factor Va-mediated prothrombin activation by prothrombinase. J Biol Chem 1995; 270; 4551-7.
33. Luckow EA, Lyons DA, Ridgeway TM, Esmon CT, Laue TM. Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction: Analysis by analytical ultracentrifugation. Biochemistry 1989; 28; 2348-54.
34. McDonald JF, Shah AM, Schwalbe RA, Kisiel W, Dahlback B, Nelsestuen GL. Comparison of naturally occurring vitamin K-dependent proteins: Correlation of amino acid sequences and membrane binding properties suggests a membrane contact site. Biochemistry 1997; 36; 5120-7.
35. Lu Y, Nelsestuen GL. Dynamic features of prothrombin interaction with phospholipid vesicles of different size and composition: Implications for protein-membrane contact. Biochemistry 1996; 35; 8193-200.
36. Mertens K, Celie PH, Kolkman JA, Lenting PJ. Factor VIII-factor IX interactions: Molecular sites involved in enzyme-cofactor complex assembly. Thromb Haemost 1999; 82; 209-17.
37. Rudolph AE, Porche-Sorbet R, Miletich JP. Definition of a factor Va binding site in factor Xa. J Biol Chem 2001; 276; 5123-8.
38. Steen M, Dahlback B. Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site. J Biol Chem 2002; 277; 38424-30.