Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults

Clinical and Experimental Allergy

Volumn 32, Issue 12, 2002, Pages 1739-1744

  Pala, Pietro ^a   Message, S D ^a   Johnston, S L ^a   Openshaw, P J M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Allergen; Asthma; Atopy; ELISPOT; IFN ; IL 4; Respiratory syncytial virus; Rhinovirus; SPT

Indexed keywords

ALLERGEN; ANTIGEN; CHIMERIC PROTEIN; GAMMA INTERFERON; HOUSE DUST ALLERGEN; INTERLEUKIN 4; RECOMBINANT PROTEIN; VIRUS PROTEIN; BET V 1 PROTEINS, BETULA PENDULA; DERMATOPHAGOIDES PTERONYSSINUS ANTIGEN P 1; FEL D 1 PROTEIN, FELIS DOMESTICUS; GLYCOPROTEIN; VEGETABLE PROTEIN; VIRUS ANTIGEN;

ADULT; AGED; AIRBORNE PARTICLE; ALLERGIC ASTHMA; ARTICLE; ATOPY; BIRD; CAT; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HOUSE DUST ALLERGY; HUMAN; HUMAN RHINOVIRUS; IMMUNOLOGICAL PROCEDURES; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SKIN TEST; TH1 CELL; TH2 CELL; ANIMAL; ASTHMA; BIOSYNTHESIS; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOLOGY; MIDDLE AGED; POLLEN;

ADULT; AGED; ALLERGENS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ANTIGENS, VIRAL; ASTHMA; CATS; FEMALE; GLYCOPROTEINS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MIDDLE AGED; PLANT PROTEINS; POLLEN; RESPIRATORY SYNCYTIAL VIRUSES; SKIN TESTS; TH1 CELLS; TH2 CELLS;

EID: 0036458685     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2002.01548.x     Document Type: Article

References (23)

1. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Medical 1992; 326:298-304.
2. Walker C, Bauer W, Braun RK et al. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. Am J Respir Crit Care Med 1994; 150:1038-48.
3. Krug N, Jung T, Napp U et al. Frequencies of T cells expressing interleukin-4 and interleukin-5 in atopic asthmatic children. Comparison with atopic asthmatic adults. Am J Respir Crit Care Med 1998; 158:754-9.
4. Krug N, Madden J, Redington AE et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14:319-26.
5. Magnan AO, Mely LG, Camilla CA et al. Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma. Am J Respir Crit Care Med 2000; 161:1790-6.
6. Cho SH, Stanciu LA, Begishivili T, Bates P J, Holgate ST, Johnston SL. Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects. Clin Exp Allergy 2002; 32:427-33.
7. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000; 161:1501-7.
8. Pala P, Bjarnason R, Sigurbergsson F, Metcalfe C, Sigurs N, Openshaw PJM. Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy. Eur Respir J 2002; 20:1-7.
9. Bryan SA, O'Connor BJ, Matti S et al. Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000; 356:2149-53.
10. Leckie M J, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet 2000; 356:2144-8.
11. Milgrom H, Fick RB, Su JQ et al. Treatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study Group. N Engl J Med 1999; 341:1966-73.
12. NHBLI/WHO. Workshop Report. Global Strategy for Asthma Management and Prevention. No. 95-3659. Bethesda, MD: National Institutes of Health, 1995.
13. Cannon MJ. Microplaque immunoperoxidase detection of infectious respiratory syncytial virus in the lungs of infected mice. J Virol Meth 1987; 16:293-301.
14. Johnston SL, Tyrrell DAJ. Diagnostic procedures for viral, rickettsial and chlamydial infections. In: Lennette EH, Schmidt NJ, eds. Rhinoviruses. Washington DC: American Public Health Association, 1995; 553-63.
15. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B, Bjorksten B. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: A prospective cohort study with matched controls. Pediatrics 1995; 95:500-5.
16. Stein RT, Sherrill D, Morgan WJ et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354:541-5.
17. Pala P, Hussell T, Openshaw PJM. Flow cytometric measurement of intracellular cytokines. J Immunol Meth 2000; 243:107-24.
18. Pattemore PK, Johnston SL, Bardin PG. Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy 1992; 22:325-36.
19. Calhoun WJ, Dick EC, Schwartz LB, Busse WW. A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest 1994; 94:2200-8.
20. Johnston SL, Pattemore PK, Sanderson G et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. Br Med 1995; 310:1225-8.
21. Busse WW. Viral infections in humans. Am J Respir Crit Care Med 1995; 151:1675-6.
22. Roberts G, Lack G. Food allergy-getting more out of your skin prick tests. Clin Exp Allergy 2000; 30:1495-8.
23. Gabrielsson S, Paulie S, Rak S et al. Specific induction of interleukin-4-producing cells in response to in vitro allergen stimulation in atopic individuals. Clin Exp Allergy 1997; 27:808-15.