Specific induction of interleukin-4-producing cells in response to in vitro allergen stimulation in atopic individuals

Clinical and Experimental Allergy

Volumn 27, Issue 7, 1997, Pages 808-815

  Gabrielsson, S ^a   Paulie, S ^a   Rak, S ^b   Lagging, E ^c   Van Hage Hamsten, M ^c   Harfast B ^c   Troye Blomberg, M ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergen specific; Atopy; ELISPOT; IFN ; IL 4

Indexed keywords

ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; PHYTOHEMAGGLUTININ;

ADULT; ARTICLE; ATOPY; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0030787979     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.1997.560878.x     Document Type: Article

References (38)

1. Johansson SGO, Bennich H, Berg T. In vitro diagnosis of atopic allergy. 3. Quantitative estimation of circulating IgE antibodies by radioallergosorbent test. Int Arch Allergy Appl Immunol 1971; 41:443-51.
2. Del Prete G, Maggi E, Parronchi P, Chrétien I, Tiri A, Macchia D, Ricci M, Banchereau J, De Vries JE, Romagnani S. IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988; 140:4193-98.
3. 2. Proc Natl Acad Sci USA 1988; 85:6880-84.
4. Vercelli D, Geha RS. Regulation of isotype switching. Curr Opin Immunol 1992; 4:794-97.
5. Coffman R, Carty J. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J Immunol 1986; 136:949-54.
6. Finkelman FD, Katona ID, Urban JF, Holmes J, Ohara J, Tung AS, Sample JvG, Paul WE. IL-4 is required to generate and sustain in vivo IgE responses. J Immunol 1988; 141:2335-41.
7. Punnonen J, Aversa G, Cocks BG, McKenzie ANJ, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 1993; 90:3730-34.
8. Mossmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. J Immunology 1986; 136:2348-57.
9. + T cell subset with an unrestricted cytokine profile. J Immunol 1989; 143:518-25.
10. Romagnani S. Lymphokine production by human T cells in disease states. Ann Rev Immunol 1994; 12:227-57.
11. + T-cell subsets. Imm Rev 1991; 123:5-22.
12. Snapper CM, Paul WE. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987; 236:944-47.
13. Sedgwick JD, Holt PG. A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J Immunol Methods 1983; 57:301-9.
14. Versteegen JMT, Logtenberg T, Ballieux RE. Enumeration of IFN-γ-producing human lymphocytes by spot-ELISA. J Immunol Methods 1988; 111:25-9.
15. Czerkinsky C, Andersson G, Ferrua B, Nordström I, Quiding M, Eriksson K, Larsson L, Hellstrand K, Ekre H-P. Detection of human cytokine-secreting cells in distinct anatomical compartments. Immunol Rev 1991; 119:5-22.
16. ElGhazali GEB, Paulie S, Andersson G, Hansson Y, Holmquist G, Sun J-B, Olsson T, Ekre HP, Troye-Blomberg M. Number of interleukin-4- and interferon-γ-secreting human T cells reactive with tetanus toxoid and the mycobacterial antigen PPD or phytohemagglutinin: distinct response profiles depending on the type of antigen used for activation. Eur J Immunol 1993; 23:2740-45.
17. Pène J, Rivier A, Lagier B, Backer WM, Michel F-B, Bousquet J. Differences in IL-4 release by PBMC are related with heterogeneity of atopy. Immunology 1994; 81:58-64.
18. Powers GD, Abbas AK, Miller RA. Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations. J Immunol 1988; 140:3352-57.
19. Kabilan L, Andersson G, Lolli F, Ekre H, Troye-Blomberg M. Detection of intracellular expression and secretion of interferon-γ at the single-cell level after activation of human T cells with tetanus toxoid in vitro. Eur J Immunol 1990; 20:1085-89.
20. + T cells stimulated by Plasmodium falciparum. Parasite Immunol 1995; 17:413-23.
21. Del Prete GF, de Carli M, D'Elios MM, Maestrelli P, Ricci M, Fabbri L, Romagnani S. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 1993; 23:1445-49.
22. Ishizuka T, Kawagoe M, Suzuki K, Hara M, Harigai M, Kawakami M, Kawaguchi Y, Hidaka T, Matsuki Y, Tanaka N, Kitani A, Nakamura H. An ultrasensitive system to detect IL-4: enzyme-linked immunosorbent assay (ELISA) combined with an avidin-biotin and enzyme amplification system. J Immunol Methods 1992; 153:213-22.
23. + T cells requires repeated antigenic stimulation. Cell Immunol 1993; 152:18-34.
24. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT. Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993; 178:2123-30.
25. Secrist H, DeKruyff RH, Umetsu DT. Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J Exp Med 1995; 181:1081-89.
26. Kurtzhals JAL, Hansen MB, Hey AS, Poulsen LK. Measurement of antigen-dependent interleukin-4 production by human peripheral blood mononuclear cells. J Immunol Methods 1992; 156:239-45.
27. Romagnani S, Maggi E, Parronchi P, Macchia D, Piccinni MP, Ricci M. Increased numbers of Th2-like CD4+ T cells in target organs and in the allergen-specific repertoire of allergic patients. Int Arch Allergy Appl Immunol 1991; 94:133-36.
28. + T lymphocytes in atopic patients. J Immunol 1990; 144:4651-56.
29. Romagnani S, Del Prete G, Maggi E, Parronchi P, Tiri A, Macchia D, Giudizi MGAF, Ricci M. Role of interleukins in induction and regulation of human IgE synthesis. Clin Immun Immunopath 1989; 50:s13-23.
30. Reinhold U, Wehrmann W, Kukel S, Kreysel HW. Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities. Clin Exp Immunol 1990; 79:374-9.
31. Hviid L, Theander TG, Abdulhadi NH, Abu-Zeid UA, Bayoumi RA, Jensen JB. Transient depletion of T cells with high LFA-1 expression from peripheral circulation during acute Plasmodium falciparum malaria. Eur J Immunol 1991; 21:1249-53.
32. Seder RA, Le Gros G, Ben-Sasson SZ, Urban J, Finkelman FD, Paul WE. Increased frequency of interleukin 4-producing T cells as a result of polyclonal priming. Use of a single-cell assay to detect interleukin 4-producing cells. Eur J Immunol 1991; 21:1241-47.
33. Le Gros G, Erard F. Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions. Curr Opin Immunol 1994; 6:453-57.
34. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδT cells in vivo. Nature 1995; 373:255-57.
35. Zlotnik A, Bean AG. Production of IL4 by non-Th2 T-cell subsets: possible role of CD4- CD8- alpha beta TCR+ and CD4 subset T cells in T helper subset regulation. Res Immunol 1993; 144:606-9.
36. Ben-Sasson S, Le Gros G, Conrad DH, Finkelman FD, Paul WE. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci USA 1990; 87:1421-25.
37. Schmitz J, Thiel A, Kuhn R, Rajewsky K, Muller W, Assenmacher M, Radbruch A. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th-cells. J Exp Med 1994; 179:1349-53.
38. Sigmundsdóttir H, Sirgurgerrsson B, Troye-Blomberg M et al. Circulating T-cells of patients with active psiorisis respond to streptococcal M-peptides sharing sequences with human epidermal keratins. Scand J Immunol 1997; in press.