메뉴 건너뛰기




Volumn 50, Issue 5, 2002, Pages 297-305

Immunotherapy of cancer through targeting of the p53 tumor antigen

Author keywords

Cancer immunotherapy; P53 tumor antigen

Indexed keywords

PROTEIN P53; TUMOR ANTIGEN; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2;

EID: 0036450278     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (75)
  • 1
    • 0027981340 scopus 로고
    • Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers
    • Angelopoulou K., Diamandis E. P., Sutherland D. J., Kellen J. A. and Bunting P. S. (1994): Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers. Int. J. Cancer, 58, 480-487.
    • (1994) Int. J. Cancer , vol.58 , pp. 480-487
    • Angelopoulou, K.1    Diamandis, E.P.2    Sutherland, D.J.3    Kellen, J.A.4    Bunting, P.S.5
  • 2
    • 0033552613 scopus 로고    scopus 로고
    • Regulation of p53 stability
    • Ashcroft M. and Vousden K. H. (1999): Regulation of p53 stability. Oncogene, 18, 7637-7643.
    • (1999) Oncogene , vol.18 , pp. 7637-7643
    • Ashcroft, M.1    Vousden, K.H.2
  • 3
    • 0033965590 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte clones, established by stimulation with the HLA-A2 binding p5365-73 wild type peptide loaded on dendritic cells in vitro, specifically recognize and lyse HLA-A2 tumour cells overexpressing the p53 protein
    • Barfoed A. M., Petersen T. R., Kirkin A. F., Thor Straten P., Claesson M. H. and Zeuthen J. (2000): Cytotoxic T-lymphocyte clones, established by stimulation with the HLA-A2 binding p5365-73 wild type peptide loaded on dendritic cells in vitro, specifically recognize and lyse HLA-A2 tumour cells overexpressing the p53 protein. Scand. J. Immunol., 51, 128-133.
    • (2000) Scand. J. Immunol. , vol.51 , pp. 128-133
    • Barfoed, A.M.1    Petersen, T.R.2    Kirkin, A.F.3    Thor Straten, P.4    Claesson, M.H.5    Zeuthen, J.6
  • 6
    • 0034319257 scopus 로고    scopus 로고
    • Identification of a ras oncogene peptide that contains both CD4(+) and CD8(+) T cell epitopes in a nested configuration and elicits both T cell subset responses by peptide or DNA immunization
    • Bristol J. A., Orsini C., Lindinger P., Thalhamer J. and Abrams S. I. (2000): Identification of a ras oncogene peptide that contains both CD4(+) and CD8(+) T cell epitopes in a nested configuration and elicits both T cell subset responses by peptide or DNA immunization. Cell. Immunol., 205, 73-83.
    • (2000) Cell. Immunol. , vol.205 , pp. 73-83
    • Bristol, J.A.1    Orsini, C.2    Lindinger, P.3    Thalhamer, J.4    Abrams, S.I.5
  • 9
    • 0021558851 scopus 로고
    • The cellular protein p53 in human tumours
    • Crawford L. V., Pim D. C. and Lamb P. (1984): The cellular protein p53 in human tumours. Mol. Biol. Med., 2, 261-272.
    • (1984) Mol. Biol. Med. , vol.2 , pp. 261-272
    • Crawford, L.V.1    Pim, D.C.2    Lamb, P.3
  • 10
    • 0018743916 scopus 로고
    • Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • DeLeo A. B., Jay G., Appella E., Dubois G. C., Law L. W. and Old L. J. (1979): Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl. Acad. Sci. USA, 76, 2420-2424.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 2420-2424
    • DeLeo, A.B.1    Jay, G.2    Appella, E.3    Dubois, G.C.4    Law, L.W.5    Old, L.J.6
  • 12
    • 0027358857 scopus 로고
    • Inhibition of DNA replication factor RPA by p53
    • Dutta A., Ruppert J. M., Aster J. C. and Winchester E. (1993): Inhibition of DNA replication factor RPA by p53. Nature, 365, 79-82.
    • (1993) Nature , vol.365 , pp. 79-82
    • Dutta, A.1    Ruppert, J.M.2    Aster, J.C.3    Winchester, E.4
  • 13
    • 0033807242 scopus 로고    scopus 로고
    • CD40 activation enhances the magnitude of cellular immune responses against p53 but not the avidity of the effectors
    • Erdile L. F. and Smith D. (2000): CD40 activation enhances the magnitude of cellular immune responses against p53 but not the avidity of the effectors. Cancer Immunol. Immunother., 49, 410-416.
    • (2000) Cancer Immunol. Immunother. , vol.49 , pp. 410-416
    • Erdile, L.F.1    Smith, D.2
  • 14
    • 12944265535 scopus 로고    scopus 로고
    • A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck
    • Eura M., Chikamatsu K., Katsura F., Obata A., Sobao Y., Takiguchi M., Song Y., Appella E., Whiteside T. L. and DeLeo A. B. (2000): A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck. Clin. Cancer Res., 6, 979-986.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 979-986
    • Eura, M.1    Chikamatsu, K.2    Katsura, F.3    Obata, A.4    Sobao, Y.5    Takiguchi, M.6    Song, Y.7    Appella, E.8    Whiteside, T.L.9    DeLeo, A.B.10
  • 16
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde R., Smits R. and Clevers H. (2001): APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer, 1, 55-67.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 17
    • 0031984762 scopus 로고    scopus 로고
    • Evidence that HLA class II-restricted human CD4+ T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms
    • Fujita H., Senju S., Yokomizo H., Saya H., Ogawa M., Matsushita S. and Nishimura Y. (1998): Evidence that HLA class II-restricted human CD4+ T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms. Eur. J. Immunol., 28, 305-316.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 305-316
    • Fujita, H.1    Senju, S.2    Yokomizo, H.3    Saya, H.4    Ogawa, M.5    Matsushita, S.6    Nishimura, Y.7
  • 18
    • 0031905632 scopus 로고    scopus 로고
    • Accumulation of the p53 protein allows recognition by human CTL of a wild-type p53 epitope presented by breast carcinomas and melanomas
    • Gnjatic S., Cai Z., Viguier M., Chouaib S., Guillet J. G. and Choppin J. (1998): Accumulation of the p53 protein allows recognition by human CTL of a wild-type p53 epitope presented by breast carcinomas and melanomas. J. Immunol., 160, 328-333.
    • (1998) J. Immunol. , vol.160 , pp. 328-333
    • Gnjatic, S.1    Cai, Z.2    Viguier, M.3    Chouaib, S.4    Guillet, J.G.5    Choppin, J.6
  • 19
    • 0025886953 scopus 로고
    • Adoptive T cell therapy of tumors: Mechanisms operative in the recognition and elimination of tumor cells
    • Greenberg P. D. (1991): Adoptive T cell therapy of tumors: Mechanisms operative in the recognition and elimination of tumor cells. Adv. Immunol., 49, 281-355.
    • (1991) Adv. Immunol. , vol.49 , pp. 281-355
    • Greenberg, P.D.1
  • 20
    • 0035869571 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances the CTL responses to the p53 self-tumor antigen
    • Hernandez J., Ko A. and Sherman L. A. (2001): CTLA-4 blockade enhances the CTL responses to the p53 self-tumor antigen. J. Immunol., 166, 3908-3914.
    • (2001) J. Immunol. , vol.166 , pp. 3908-3914
    • Hernandez, J.1    Ko, A.2    Sherman, L.A.3
  • 21
    • 0343938862 scopus 로고    scopus 로고
    • The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire
    • Hernandez J., Lee P. P., Davis M. M. and Sherman L. A. (2000): The use of HLA A2.1/p53 peptide tetramers to visualize the impact of self tolerance on the TCR repertoire. J. Immunol., 164, 596-602.
    • (2000) J. Immunol. , vol.164 , pp. 596-602
    • Hernandez, J.1    Lee, P.P.2    Davis, M.M.3    Sherman, L.A.4
  • 24
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R., Tanaka H. and Yasuda H. (1997): Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett., 420, 25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 28
    • 0031986115 scopus 로고    scopus 로고
    • The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity
    • Hurpin C., Rotarioa C., Bisceglia H., Chevalier M., Tartaglia J. and Erdile L. (1998): The mode of presentation and route of administration are critical for the induction of immune responses to p53 and antitumor immunity. Vaccine, 16, 208-215.
    • (1998) Vaccine , vol.16 , pp. 208-215
    • Hurpin, C.1    Rotarioa, C.2    Bisceglia, H.3    Chevalier, M.4    Tartaglia, J.5    Erdile, L.6
  • 33
    • 0035113705 scopus 로고    scopus 로고
    • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson K. L., Schiffman K. and Disis M. L. (2001): Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J. Clin. Invest., 107, 477-484.
    • (2001) J. Clin. Invest. , vol.107 , pp. 477-484
    • Knutson, K.L.1    Schiffman, K.2    Disis, M.L.3
  • 34
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane D. P. and Crawford L. V. (1979): T antigen is bound to a host protein in SV40-transformed cells. Nature, 278, 261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 35
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine A. J., Momand J. and Finlay C. A. (1991): The p53 tumour suppressor gene. Nature, 351, 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 36
    • 0030665146 scopus 로고    scopus 로고
    • Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
    • Mayo L. D., Turchi J. J. and Berberich S. J. (1997): Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res., 57, 5013-5016.
    • (1997) Cancer Res. , vol.57 , pp. 5013-5016
    • Mayo, L.D.1    Turchi, J.J.2    Berberich, S.J.3
  • 39
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J., Zambetti G. P., Olson D. C., George D. and Levine A. J. (1992): The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69, 1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 42
    • 0032473562 scopus 로고    scopus 로고
    • Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors
    • Ossendorp F., Mengede E., Camps M., Filius R. and Melief C. J. (1998): Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med., 187, 693-702.
    • (1998) J. Exp. Med. , vol.187 , pp. 693-702
    • Ossendorp, F.1    Mengede, E.2    Camps, M.3    Filius, R.4    Melief, C.J.5
  • 43
    • 0030040893 scopus 로고    scopus 로고
    • Induction of measles virus-specific cytotoxic T-cell responses after intranasal immunization with synthetic peptides
    • Partidos C. D., Vohra P. and Steward M. W. (1996): Induction of measles virus-specific cytotoxic T-cell responses after intranasal immunization with synthetic peptides. Immunology, 87, 179-185.
    • (1996) Immunology , vol.87 , pp. 179-185
    • Partidos, C.D.1    Vohra, P.2    Steward, M.W.3
  • 44
    • 0030946527 scopus 로고    scopus 로고
    • Identification of potential HLA-A*0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA)
    • Ras E., van der Burg S. H., Zegveld S. T., Brandt R. M., Kuppen P. J., Offringa R., Warnarr S. O., Van De Velde C. J. and Melief C. J. (1997): Identification of potential HLA-A*0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA). Hum. Immunol., 53, 81-89.
    • (1997) Hum. Immunol. , vol.53 , pp. 81-89
    • Ras, E.1    Van der Burg, S.H.2    Zegveld, S.T.3    Brandt, R.M.4    Kuppen, P.J.5    Offringa, R.6    Warnarr, S.O.7    Van De Velde, C.J.8    Melief, C.J.9
  • 45
    • 0021004708 scopus 로고
    • Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
    • Reich N. C., Oren M. and Levine A. J. (1983): Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol. Cell. Biol., 3, 2143-2150.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 2143-2150
    • Reich, N.C.1    Oren, M.2    Levine, A.J.3
  • 46
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge J. P., Di Rosa F. and Matzinger P. (1998): A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature, 393, 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    Di Rosa, F.2    Matzinger, P.3
  • 47
    • 0022390692 scopus 로고
    • p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors
    • Rogel A., Popliker M., Webb C. G. and Oren M. (1985): p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol. Cell. Biol., 5, 2851-2855.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2851-2855
    • Rogel, A.1    Popliker, M.2    Webb, C.G.3    Oren, M.4
  • 48
    • 0023941393 scopus 로고
    • Role of helper T-lymphocytes in rejection of UV-induced murine skin cancers
    • Romerdahl C. A. and Kripke M. L. (1988): Role of helper T-lymphocytes in rejection of UV-induced murine skin cancers. Cancer Res., 48, 2325-2328.
    • (1988) Cancer Res. , vol.48 , pp. 2325-2328
    • Romerdahl, C.A.1    Kripke, M.L.2
  • 50
    • 0035825583 scopus 로고    scopus 로고
    • Safety and immunogenicity of ALVAC wild-type human p53 (vCP207) by the intravenous route in rhesus macaques
    • Rosenwirth B., Kuhn E. M., Heeney J. L., Hurpin C., Tartaglia J., Bonnet M. C., Moingeon P. and Erdile L. (2001): Safety and immunogenicity of ALVAC wild-type human p53 (vCP207) by the intravenous route in rhesus macaques. Vaccine, 19, 1661-1670.
    • (2001) Vaccine , vol.19 , pp. 1661-1670
    • Rosenwirth, B.1    Kuhn, E.M.2    Heeney, J.L.3    Hurpin, C.4    Tartaglia, J.5    Bonnet, M.C.6    Moingeon, P.7    Erdile, L.8
  • 51
    • 0029978501 scopus 로고    scopus 로고
    • p53 as a target for cancer vaccines: Recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge
    • Roth J., Dittmer D., Rea D., Tartaglia J., Paoletti E. and Levine A. J. (1996): p53 as a target for cancer vaccines: Recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc. Natl. Acad. Sci. USA, 93, 4781-4786.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4781-4786
    • Roth, J.1    Dittmer, D.2    Rea, D.3    Tartaglia, J.4    Paoletti, E.5    Levine, A.J.6
  • 52
    • 0031963721 scopus 로고    scopus 로고
    • Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules
    • Sadovnikova E., Jopling L. A., Soo K. S. and Stauss H. J. (1998): Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules. Eur. J. Immunol., 28, 193-200.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 193-200
    • Sadovnikova, E.1    Jopling, L.A.2    Soo, K.S.3    Stauss, H.J.4
  • 53
    • 0029826486 scopus 로고    scopus 로고
    • Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy
    • Sadovnikova E. and Stauss H. J. (1996): Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy. Proc. Natl. Acad. Sci. USA, 93, 13114-13118.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13114-13118
    • Sadovnikova, E.1    Stauss, H.J.2
  • 55
    • 0023620603 scopus 로고
    • CD4+ helper T cells are required for resistance to a highly metastatic murine tumor
    • Schild H. J., Kyewski B., Von Hoegen P. and Schirrmacher V. (1987): CD4+ helper T cells are required for resistance to a highly metastatic murine tumor. Eur. J. Immunol., 17, 1863-1866.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 1863-1866
    • Schild, H.J.1    Kyewski, B.2    Von Hoegen, P.3    Schirrmacher, V.4
  • 56
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger S. P., Toes R. E., van der Voort E. I., Offringa R. and Melief C. J. (1998): T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature, 393, 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 57
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh S. Y., Ikeda M., Taya Y. and Prives C. (1997): DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91, 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 58
    • 0028203840 scopus 로고
    • Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs
    • Shirai M., Pendleton C. D., Ahlers J., Takeshita T., Newman M. and Berzofsky J. A. (1994): Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. J. Immunol., 152, 549-556.
    • (1994) J. Immunol. , vol.152 , pp. 549-556
    • Shirai, M.1    Pendleton, C.D.2    Ahlers, J.3    Takeshita, T.4    Newman, M.5    Berzofsky, J.A.6
  • 60
    • 0032909172 scopus 로고    scopus 로고
    • Immunotherapy with CTLs restricted by nonself MHC
    • Stauss H. J. (1999): Immunotherapy with CTLs restricted by nonself MHC. Immunol. Today, 20, 180-183.
    • (1999) Immunol. Today , vol.20 , pp. 180-183
    • Stauss, H.J.1
  • 64
    • 0033103127 scopus 로고    scopus 로고
    • CD4 T cells and their role in antitumor immune responses
    • Toes R. E., Ossendorp F., Offringa R. and Melief C. J. (1999): CD4 T cells and their role in antitumor immune responses. J. Exp. Med., 189, 753-756.
    • (1999) J. Exp. Med. , vol.189 , pp. 753-756
    • Toes, R.E.1    Ossendorp, F.2    Offringa, R.3    Melief, C.J.4
  • 65
    • 1842370254 scopus 로고    scopus 로고
    • Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo
    • Tuting T., Deleo A. B., Lotze M. T. and Storkus W. J. (1997): Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo. Eur. J. Immunol., 27, 2702-2707.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2702-2707
    • Tuting, T.1    Deleo, A.B.2    Lotze, M.T.3    Storkus, W.J.4
  • 66
    • 0344061572 scopus 로고    scopus 로고
    • Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen
    • Tuting T., Gambotto A., Robbins P. D., Storkus W. J. and Deleo A. B. (1999): Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen. Gene Ther., 6, 629-636.
    • (1999) Gene Ther. , vol.6 , pp. 629-636
    • Tuting, T.1    Gambotto, A.2    Robbins, P.D.3    Storkus, W.J.4    Deleo, A.B.5
  • 67
    • 0035314002 scopus 로고    scopus 로고
    • Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
    • Van Den Eynde B. J. and Morel S. (2001): Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome. Curr. Opin. Immunol., 13, 147-153.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 147-153
    • Van Den Eynde, B.J.1    Morel, S.2
  • 72
    • 0028198310 scopus 로고
    • Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA-A*0201 peptide consensus motif
    • Wiedenfeld E. A., Fernandez-Vina M., Berzofsky J. A. and Carbone D. P. (1994): Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA-A*0201 peptide consensus motif. Cancer Res., 54, 1175-1177.
    • (1994) Cancer Res. , vol.54 , pp. 1175-1177
    • Wiedenfeld, E.A.1    Fernandez-Vina, M.2    Berzofsky, J.A.3    Carbone, D.P.4
  • 73
    • 0035399593 scopus 로고    scopus 로고
    • Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells
    • Woerner S. M., Gebert J., Yuan Y. P., Sutter C., Ridder R., Bork P. and Von Knebel Doeberitz M. (2001): Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells. Int. J. Cancer, 93, 12-19.
    • (2001) Int. J. Cancer , vol.93 , pp. 12-19
    • Woerner, S.M.1    Gebert, J.2    Yuan, Y.P.3    Sutter, C.4    Ridder, R.5    Bork, P.6    Von Knebel Doeberitz, M.7
  • 74
    • 0027234492 scopus 로고
    • A comparison of the biological activities of wild-type and mutant p53
    • Zambetti G. P. and Levine A. J. (1993): A comparison of the biological activities of wild-type and mutant p53. FASEB J., 7, 855-865.
    • (1993) FASEB J. , vol.7 , pp. 855-865
    • Zambetti, G.P.1    Levine, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.