Characterization of 5-HT receptor subtypes mediating contraction in human umbilical vein. 2. Evidence of involvement of 5-HT1B receptors using functional studies

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 366, Issue 6, 2002, Pages 596-604

  Rogines Velo, María Pía ^a   Pelorosso, Facundo Germán ^a   Zold, Camila Lidia ^a   Brodsky, Paula Tamara ^a   Rothlin, Rodolfo Pedro ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

5 HT; 5 HT1B receptors; Functional studies; Human umbilical vein; KCl sub threshold concentration; Ketanserin; L 694,247; SB 216641; Sumatriptan

Indexed keywords

3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; ALPHA METHYLSEROTONIN; BRADYKININ; KETANSERIN; N [4 [5 [3 (2 AMINOETHYL) 1H INDOL 5 YL] 1,2,4 OXADIAZOL 3 YL]BENZYL]METHANESULFONAMIDE; POTASSIUM CHLORIDE; RECEPTOR SUBTYPE; SB 216641; SEROTONIN; SEROTONIN 1B AGONIST; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D AGONIST; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; SEROTONIN RECEPTOR; SUMATRIPTAN; UNCLASSIFIED DRUG; SEROTONIN 2B RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; HUMAN; HUMAN TISSUE; NEWBORN; UMBILICAL VEIN; VENOCONSTRICTION; DOSE RESPONSE; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; VASOCONSTRICTION;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; UMBILICAL VEINS; VASOCONSTRICTION;

EID: 0036446855     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0637-8     Document Type: Article

References (40)

1. Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48-58
2. Bard JA, Kucharewicz SA, Zgombick JM, Weinshank RL, Branchek TA, Cohen ML (1996) Differences in ligand binding profiles between cloned rabbit and human 5-HT1D alpha and 5-HT1D beta receptors: Ketanserin and methiothepin distinguish rabbit 5-HT1D receptor subtypes. Naunyn Schmiedeberg's Arch Pharmacol 354:237-244
3. 1D-like receptors, and a comparison with grafted veins. Naunyn Schmiedeberg's Arch Pharmacol 345:500-508
4. 1D receptor agonist. Br J Pharmacol 110:1196-1200
5. Bodelsson M, Tornebrandt K, Bertilsson IL, Arneklo-Nobin B (1992) Heterogeneity of contractile 5-HT receptors in human hand veins. Eur J Pharmacol 219:455-460
6. 1D beta-like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedeberg's Arch Pharmacol 353:281-289
7. 1-like receptor in rabbit renal artery. Eur J Pharmacol 231:469-472
8. 1D-like receptors mediate contraction of partially depolarized rabbit renal arteries. J Pharmacol Exp Ther 270:650-655
9. 1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. Br J Pharmacol 114:309-314
10. Cocks TM, Kemp BK, Pruneau D, Angus JA (1993) Comparison of contractile responses to 5-hydroxytryptamine and sumatriptan in human isolated coronary artery: Synergy with the thromboxane A2-receptor agonist, U46619. Br J Pharmacol 110: 360-368
11. Connor HE, Beattie DT (1996) 5-Hydroxytryptamine receptor subtypes and migraine. In: Sandler M, Ferrari M, Harnett S (eds) Migraine: Pharmacology and Genetics. Chapman and Hall, London, pp 18-27
12. Cortijo J, Marti-Cabrera M, Bernabeu E, Doménech T, Bou J, Fernández AG, Beleta J, Palacios JM, Morcillo EJ (1997) Characterization of 5-HT receptors on human pulmonary artery and vein: Functional and binding studies. Br J Pharmacol 122:1455-1463
13. DeLean A, Munson PJ, Rodbard D (1978) Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235:E97-E102
14. 1-adrenoceptor subtypes mediating vasoconstriction in human umbilical vein. Br J Pharmacol 126:437-442
15. 1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127:1327-1336
16. (1B/1D) receptor-mediated contraction of the rabbit isolated renal artery. Br J Pharmacol 130:835-842
17. Jenkinson DH, Barnard EA, Hoyer D, Humphrey PP, Leff P, Shankley NP (1995) International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology. Pharmacol Rev 47:255-266
18. Kenakin TP (1992) Tissue response as a functional discriminator of receptor heterogeneity: Effects of mixed receptor populations on Schild regressions. Mol Pharmacol 41:699-707
19. 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Br J Pharmacol 120:819-826
20. Lovren F, Li XF, Lytton J, Triggle C (1999) Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. Br J Pharmacol 127: 1247-1255
21. 1B/1D receptor antagonist GR55562. Pharmacol Toxicol 86:287-290
22. 1-like receptor-mediated vasoconstrictia in human pulmonary artery. Br J Pharmacol 119:277-282
23. Martin GR, Hoyer D, Villalon C, Göthert M, Middlemiss DN (2000) 5-Hydroxytryptamine receptors. In: IUPHAR (ed) The IUPHAR Compendium of Receptor Characterization and Classification. IUPHAR Media, Girdleston, pp 231-251
24. 1B receptor. Br J Pharmacol 128:730-734
25. 1B-like receptors of rabbit ear artery. J Pharmacol Exp Ther 283:653-660
26. Nilsson T, Longmore J, Shaw D, Pantev E, Bard JA, Branchek T, Edvinsson L (1999a) Characterisation of 5-HT receptors in human coronary arteries by molecular and pharmacological techniques. Eur J Pharmacol 372:49-56
27. 1B receptors in human cerebral arteries: Pharmacological characterization and localization with immunocytochemistry. Br J Pharmacol 128:1133-1140
28. 1D receptors. Naunyn Schmiedeberg's Arch Pharmacol 356:312-320
29. 2A receptors using functional and radioligand binding assays. Naunyn Schmiedeberg's Arch Pharmacol (in press)
30. 1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedeberg's Arch Pharmacol 356:321-327
31. 1D beta receptor mRNA expression in human umbilical vein endothelial cells. Naunyn Schmiedeberg's Arch Pharmacol 352:580-582
32. 2A "silent" receptors in rabbit ear artery. J Pharmacol Exp Ther 289:354-360
33. 1 receptor-induced smooth muscle contraction in dog saphenous vein. Br J Pharmacol 105: 603-608
34. Van Nueten JM, Janssen PA, De Ridder A, Vanhoutte PM (1982) Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468). Eur J Pharmacol 77:281-287
35. 2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. Br J Pharmacol 117:283-289
36. 2 receptors. Pharmacol Toxicol 78:50-54
37. 1D beta receptors. Eur J Pharmacol 287:79-84
38. 2A receptors mediate 5-hydroxytryptamine-induced contraction of rabbit isolated mesenteric artery. Naunyn Schmiedeberg's Arch Pharmacol 352:127-131
39. 1-like receptor-mediated contraction in the human internal mammary artery. J Cardiovasc Pharmacol 28:6-10
40. 1D beta receptor subtypes. Eur J Pharmacol 291:9-15