Mechanisms of epithelial injury and inflammation in gastrointestinal diseases

Reviews in Gastroenterological Disorders

Volumn 2, Issue SUPPL. 2, 2002, Pages

  Orlando, Roy C ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Cytokines; Mitochondria; Nitric oxide; Osmoregulation; Superoxide anion

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CYTOKINE; GENE PRODUCT; REACTIVE OXYGEN METABOLITE;

BARRETT ESOPHAGUS; CALCIUM CELL LEVEL; CANCER RISK; CARCINOGENESIS; CELL DAMAGE; CELL DEATH; CHRONIC INFLAMMATION; COLON CARCINOMA; CROHN DISEASE; CYTOSOL; ESOPHAGUS CARCINOMA; GENE MUTATION; HUMAN; INFLAMMATORY CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; OSMOREGULATION; REVIEW; SMALL INTESTINE CARCINOMA;

ADENOCARCINOMA; BARRETT ESOPHAGUS; CELL DEATH; COLONIC NEOPLASMS; CROHN DISEASE; ESOPHAGEAL NEOPLASMS; HUMANS; INFLAMMATION; RISK FACTORS; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 0036444325     PISSN: 1533001X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Spechler SJ. Barrett's esophagus. In: Orlando RC, ed. Gastroesophageal Reflux Disease. New York, NY: Marcel Dekker, Inc; 2000:219-258.
2. Orlando RC. Pathophysiology of gastroesophageal reflux disease: offensive factors and tissue resistance. In: Orlando RC, ed. Gastroesophageal Reflux Disease. New York, NY: Marcel Dekker, Inc; 2000:165-192.
3. Carney CN, Orlando RC, Powell DW, Dotson MM. Morphologic alterations in early acid-induced epithelial injury of the rabbit esophagus. Lab Invest. 1981;45:198-208.
4. Tobey NA, Carson JL, Alkiek RA, Orlando RC. Dilated intercellular spaces: a morphological feature of acid reflux-damaged human esophageal epithelium. Gastroenterology. 1996;111:1200-1205.
5. Tobey NA, Reddy SP, Keku TO, et al. Mechanisms of HCl-induced lowering of intracellular pH in rabbit esophageal epithelial cells. Gastroenterology. 1993;105:1035-1044.
6. Tobey NA, Cragoe, EJ Jr, Orlando RC. HCl-induced cell edema in rabbit esophageal epithelium: a bumetanide-sensitive process. Gastroenterology. 1995;109:414-421.
7. Cotran R, Vinay K, Robbins S, Schoen, F. Pathologic Basis of Disease. 5th ed. Philadelphia, Pa: WB Saunders Co; 1994:1-34.
8. Lemasters JJ. V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol. 1999;276(1 pt1):G1-G6.
9. Qian T, Nieminen AL, Herman B, Lemasters JJ. Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol. 1997;273(6 pt 1):C1783-C1792.
10. Stenson WF. Inflammatory bowel disease. In: Yamada T, ed. Textbook of Gastroenterology, 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 1999:1775-1839.
11. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599-603.
12. Ogura Y, Bonen DK, Inohara H, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
13. Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122:867-874.
14. Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology. 2002;122:854-866.
15. Hollander D, Vadheim CM, Brettholtz E, et al. Increased intestinal permeability in patients with Crohn's and their relatives: a possible etiologic factor. Ann Int Med. 1986;105:883-885.
16. Singer II, Kawka DW Scott S, et al. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology. 1996;111:871-885.
17. Iijima K, Henry E, Moriya A, et al. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology. 2002;122:1248-1257.
18. Boland CR. Molecular basis for stool-based DNA tests for colorectal cancer: a primer for clinicians. Rev Gastroenterol Disord. 2002;2(suppl 1):S12-S19.