Iron dependence of tryptophan hydroxylase activity in RBL2H3 cells and its manipulation by chelators

European Journal of Biochemistry

Volumn 261, Issue 3, 1999, Pages 734-739

  Hasegawa, Hiroyuki ^a   Oguro, Kazuya ^a   Naito, Yasuhisa ^b   Ichiyama, Arata ^b  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b NONE

Author keywords

Desferrioxamine; Hemin; Iron pool; Serotonin; SIH; Tryptophan hydroxylase

Indexed keywords

3 HYDROXYBENZYLHYDRAZINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DECARBOXYLASE INHIBITOR; DEFEROXAMINE; HEMIN; IRON; IRON CHELATING AGENT; ISONIAZID DERIVATIVE; SALICYLALDEHYDE; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IRON CHELATION; MAST CELL; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE;

ANIMALS; CELL-FREE SYSTEM; DEFEROXAMINE; ENZYME ACTIVATION; HEMIN; IRON; IRON CHELATING AGENTS; RATS; TRYPTOPHAN HYDROXYLASE; TUMOR CELLS, CULTURED;

EID: 0033135390     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00316.x     Document Type: Article

References (37)

1. 1. Ichiyama, A., Nakamura, S., Nishizuka, Y. & Hayaishi, O. (1970) Enzymic studies on the biosynthesis of serotonin in mammalian brain. J. Biol. Chem. 245, 1699-1709.
2. 2. Tong, J.H. & Kaufman, S. (1975) Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain. J. Biol. Chem. 250, 4152-4158.
3. 3. Kuhn, D.M., Ruskin, B. & Lovenberg, W. (1980) Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity. J. Biol. Chem. 255, 4137-4143.
4. 4. Nakata, H. & Fujisawa, H. (1982) Purification and properties of tryptophan 5-monooxygenase from rat brainstem. Eur. J. Biochem. 122, 41-47.
5. 5. Cash, C.D., Vayer, P., Mandel, P. & Maitre, M. (1985) Tryptophan 5-hydroxylase. Rapid purification from whole rat brain and production of a specific antiserum. Eur. J. Biochem. 149, 239-245.
6. 6. Ichiyama, A., Hori, S., Mashimo, Y., Nukiwa, T. & Makuuchi, H. (1974) The activation of bovine pineal tryptophan 5-monooxygenase. FEBS Lett. 40, 88-91.
7. 7. Ichiyama, A., Hasegawa, H., Tohyama, C., Dohmoto, C. & Kataoka, T. (1976) Some properties of bovine pineal tryptophan hydroxylase. Adv. Exp. Med. Biol. 74, 103-117.
8. 8. Hasegawa, H., Yanagisawa, M., Inoue, F., Yanaihara, N. & Ichiyama, A. (1987) Demonstration of non-neural tryptophan 5-monooxygenase in mouse intestinal mucosa. Biochem. J. 248, 501-509.
9. 9. Inoue, F., Hasegawa, H., Yamada, M. & Ichiyama, A. (1987) The serotonin content and tryptophan 5-monooxygemase activity in the stomach of an athymic mouse and mast cell-deficient mouse. Biomed. Res. 8, 53-59.
10. 10. Sato, T.L., Jequier, E., Lovenberg, W. & Sjoerdsma, A. (1967) Characterization of a tryptophan hydroxylating enzyme from malignant mouse mast cell. Eur. J. Pharmacol. 1, 18-25.
11. 11. Hosoda, S. (1975) Further studies on tryptophan hydroxylase from neoplastic murine mast cells. Biochim. Biophys. Acta 397, 58-68.
12. 12. Nakata, H. & Fujisawa, H. (1982) Tryptophan 5-monooxygenase from mouse mastocytoma P815. A simple purification and general properties. Eur. J. Biochem. 124, 595-601.
13. 13. Hasegawa, H., Yanagisawa, M., Ichiyama, A. (1983) Three discrete activity states of mastocytoma tryptophan 5-monooxygenase. In Oxygenases and Oxygen Metabolism (Nozaki, M., Yamamoto, S., Ishimura, Y., Coon, M.J., Ernster, L. & Estabrook, R.W., eds.), pp. 296-304. Academic Press Inc., London, UK.
14. 14. Yanagisawa, M., Hasegawa, H., Ichiyama, A., Hosoda, S. & Nakamura, W. (1984) Comparison of serotonin-producing murine mastocytomas, P-815 and FMA3: Determination of tryptophan hydroxylase, aromatic L-amino acid decarboxylase, and cellular concentration of tryptophan, 5-hydroxytryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Biomed. Res. 5, 19-28.
15. 15. Hasegawa, H., Kojima, M., Iida, Y., Oguro, K. & Nakanishi, N. (1996) Stimulation of tryptophan hydroxylase production in a serotonin-producing cell line (RBL2H3) by intracellular calcium mobilizing reagents. FEBS Lett. 392, 289-292.
16. 16. Hosoda, S., Nakamura, W. & Takatsuki, K. (1977) Properties of tryptophan hydroxylase from human carcinoid tumor. Biochim. Biophys. Acta 482, 27-34.
17. 17. Jequier, E., Robinson, D.S., Lovenberg, W. & Sjoerdsma, A. (1969) Further studies on tryptophan hydroxylase in rat brainstem and beef pineal. Biochem. Pharmacol. 18, 1071-1081.
18. 18. Kuhn, D.M., Rosenberg, R.C. & Lovenberg, W. (1979) Determination of some molecular parameters of tryptophan hydroxylase from rat midbrain and murine mast cell. J. Neurochem. 33, 15-21.
19. 19. Kuhn, D.M., Meyer, M.A. & Lovenberg, W. (1980) Comparisons of tryptophan hydroxylase from a malignant murine mast cell tumor and rat mesencephalic tegmentum. Arch. Biochem. Biophys. 199, 355-361.
20. 20. Dumas, S., Darmon, M.C., Delort, J. & Mallet, J. (1989) Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: evidence for a role of translation efficiency. J. Neurosci. Res. 24, 537-547.
21. 21. Kim, K.S., Wessel, T.C., Stone, D.M., Carver, C.H., Joh, T.H. & Park, D.H. (1991) Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neurons. Brain Res. Mol. Brain Res. 9, 277-283.
22. 2+-, calmodulin-dependent protein kinase. J. Biol. Chem. 256, 5405-5409.
23. 23. Ichimura, T., Isobe, T., Okuyama, T., Takahashi, N., Araki, K., Kuwano, R. & Takahashi, Y. (1988) Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases. Proc. Natl Acad. Sci. USA 85, 7084-7088.
24. 24. Hamon, M., Bourgoin, S., Hery, F. & Simonnet, G. (1978) Characteristics of the activation by dithiothreitol and Fe (2+) of tryptophan hydroxylase from the rat brain. Neurochem. Res. 3, 585-598.
25. 25. Hasegawa, H., Yanagisawa, M., Inoue, F. & Ichiyama, A. (1983) Mouse mastocytoma tryptophan hydroxylase. Role of iron and catalase in the expression of enzyme activity after activation by anaerobic preincubation with dithiothreitol. In Chemistry and Biology of Pteridines (Blair, J.A., ed.), pp. 796-799. Walter de Gruyter, Berlin.
26. 2+ for tryptophan 5-monooxygenease from mouse mastocytoma P-815. In Chemistry and Biology of Pteridines (Cooper, B.A. & Whitehead, V.M., eds.), pp. 369-372. Walter de Gruyter, Berlin.
27. 27. Hasegawa, H., Ichiyama, A. (1987) Mechanism of activation of tryptophan 5-monooxygenase by mercaptides. In Unconjugated Pterins and Related Biogenic Amines (Curtius, H.-C., Blau, N. & Levine, R.A., eds.), pp. 353-358. Walter de Gruyter, Berlin.
28. 28. Hasegawa, H., Kobayashi, T., Ichiyama, A. (1991) Iron aquisition by tryptophan hydroxylase is a bottle neck of serotonin biosynthesis. In Pterins and Biogenic Amines in Neurology. Pediatrics, and Immumology (Blau, N., Curtius, H.-C., Levine, R.A. & Cotton, R.G.H., eds.), pp. 245-254. Lakeshore Publishing Co, Grosse Pointe, MI, USA.
29. 29. Rouault, T., Rao, K., Harford, J., Mattia, E. & Klausner, R.D. (1985) Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis. J. Biol. Chem. 260, 14862-14866.
30. 30. Breuer, W., Epsztejn, S. & Cabantchik, Z.I. (1995) Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron (II). J. Biol. Chem 270, 24209-24215.
31. 31. Ponka, P. & Schulman, H.M. (1985) Acquisition of iron from transferrin regulates reticulocyte heme synthesis. J. Biol. Chem. 260, 14717-14721.
32. 32. Siraganian, R.P., McGivney, A., Barsumian, E.L., Crews, F.T., Hirata, F. & Axelrod, J. (1982) Variants of rat basophilic leukemia cell line for the study of histamine release. Fedration Proc. 41, 30-34.
33. 33. Nagatsu, T., Sawada, M. & Yamaguchi, T. (1983) Tryptophan hydroxylase system in brain tissue slices assayed by hight-performance liquid chromatography. Neurochem. Int. 5, 603-609.
34. 34. Gottschall, D.W., Dietrich, R.F., Benkovic, S.J. & Shiman, R. (1982) Phenylalanine hydroxylase. Correlation of the iron content with activity and the preparation and reconstitution of the apoenzyme. J. Biol. Chem. 257, 845-849.
35. 35. Hasegawa, H. & Ichiyama, A. (1987) Tryptophan 5-monooxygenase from mouse mastocytoma: High-performance liquid chromatography assay. Meth Enzymol. 142, 88-92.
36. 36. Fukushima, T. & Nixon, J.C. (1980) Analysis of reduced forms of biopterin in biological tissues and fluids. Anal. Biochem. 102, 176-188.
37. 37. Hasegawa, H., Oguro, K. & Ichiyama, A. (1993) Intracellular tryptophan hydroxylase activity assessed by metabolic assay: an interpretation of in vitro activation of the enzyme. Pteridines 4, 76-80.