Myo-inositol-1-phosphate (MIP) synthase: A possible new target for antibipolar drugs

Bipolar Disorders

Volumn 4, Issue SUPPL. 1, 2002, Pages 15-20

  Agam, Galila ^a   Shamir, Alon ^a   Shaltiel, Galit ^a   Greenberg, Miriam L ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Human; Inositol metabolism; myo inositol 1 phosphate synthase; Regulation; Yeast

Indexed keywords

INOSITOL; INOSITOL 1 PHOSPHATASE; INOSITOL PHOSPHATE; LITHIUM; MYOINOSITOL 1 PHOSPHATE SYNTHASE; PHOSPHATIDYLINOSITIDE; VALPROIC ACID;

ANIMAL CELL; CELL CYCLE; CELL LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SYNTHESIS; EUKARYOTE; GENOMICS; HUMAN; HUMAN CELL; HYPOTHESIS; MANIC DEPRESSIVE PSYCHOSIS; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHOPHARMACOLOGY; REGULATORY MECHANISM; REVIEW; YEAST CELL;

ANIMALS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; BLOOD CELLS; ENZYME INHIBITORS; EUKARYOTIC CELLS; HUMANS; INOSITOL; LITHIUM; MODELS, BIOLOGICAL; PHOSPHORIC MONOESTER HYDROLASES; PREFRONTAL CORTEX; SACCHAROMYCES CEREVISIAE; VALPROIC ACID;

EID: 0036384932     PISSN: 13985647     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-5618.4.s1.2.x     Document Type: Review

References (45)

1. Berridge MJ, Irvine RF. Inositol phosphates and cell signalling. Nature 1989; 341: 197-205.
2. Greenberg ML, Lopes JM. Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev 1996; 60: 1-20.
3. Hirsch JP, Henry SA. Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol Cell Biol 1986; 6: 3320-3328.
4. Murray M, Greenberg ML. Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source, and growth stage and is decreased by lithium and valproate. Mol Microbiol 2000; 36: 651-661.
5. Lopez F, Leube M, Gil-Mascarell R, Navarro-Avino JP, Serrano R. The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair. Mol Microbiol 1999; 31: 1255-1264.
6. Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. Mol Psychiatry 1997; 2: 393-397.
7. Sjoholt G, Gulbrandsen AK, Lovlie R, Berle JO, Molven A, Steen VM. A human myo-inositol monophosphatase gene (IMPA-2) localized in a putative suseptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients. Mol Psychiatry 2000; 5: 172-180.
8. Yoshikawa T Padigaru M Karkera JD et al. Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2). Mol Psychiatry 2000; 5: 165-171.
9. Berrettini WH, Ferraro TN, Goldin LR et al. Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci USA 1994; 91: 5918-5921.
10. Freimer NB, Reus VI, Escamilla M et al. An approach to investigating linkage for bipolar disorder using large Costa Rican pedigrees. Am J Med Genet 1996; 67: 254-263.
11. Sjoholt G, Molven A, Lovlie R, Wilcox A, Sikela JM, Steen VM. Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). Genomics 1997; 45: 113-122.
12. Atack JR, Broughton HB, Pollack SJ. Structure and mechanism of inositol monophosphatase. FEBS Lett 1995; 361: 1-7.
13. Eisenberg F Jr. D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. J Biol Chem 1967; 242: 1375-1382.
14. Wong YH, Kalmbach SJ, Hartman BK, Sherman WR. Immunohistochemical staining and enzyme activity measurements show myo-inositol-1-phosphate synthase to be localized in the vasculature of brain. J Neurochem 1987; 48: 1434-1442.
15. Tian F, Migaud M, Frost JW. Myo-inositol 1 phosphate synthase: does a single active site amono acid catalyze multiple proton transfers? J Am Chem Soc 1999; 121: 5795-5796.
16. Tian F, Arthur JC, Peng J, Migaud M, Frost JW. Myo-inositol 1 phosphate synthase. a model of enzyme efficiency and enzyme opportunism. ACS National Meeting, Anaheim, CA, USA, 1999, 217.
17. Hallcher LM, Sherman WR. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 1980; 255: 10896-10901.
18. Berridge MJ. Phosphoinositides and signal transductions. Rev Clin Basic Pharm 1985; 5(Suppl.): 5S-13S.
19. Kendall DA, Nahorski SR. Acute and chronic lithium treatments influence agonist and depolarization-stimulated inositol phospholipid hydrolysis in rat cerebral cortex. J Pharmacol Exp Ther 1987; 241: 1023-1027.
20. Casebolt TL, Jope RS. Long-term lithium treatment selectively reduces receptor-coupled inositol phospholipid hydrolysis in rat brain. Biol Psychiatry 1989; 25: 329-340.
21. Godfrey PP, McClue SJ, White AM, Wood AJ, Grahame-Smith DG. Subacute and chronic in vivo lithium treatment inhibits agonist- and sodium fluoride-stimulated inositol phosphate production in rat cortex. J Neurochem 1989; 52: 498-506.
22. Jope RS, Williams MB. Lithium and brain signal transduction systems. Biochem Pharmacol 1994; 47: 429-441.
23. Manji HK, Lenox RH. Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C. Synapse 1994; 16: 11-28.
24. Vaden DL, Ding D, Peterson B, Greenberg ML. Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis. J Biol Chem 2001; 276: 15466-15471.
25. O'Donnell T, Rotzinger S, Nakashima TT, Hanstock CC, Ulrich M, Silverstone PH. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain. Brain Res 2000; 880: 84-91.
26. Nemanov L, Ebstein RP, Shamir A, Etack JR, Belmaker RH, Agam G eds. Effect of Affective Disorders and Lithium Treatment on Inositol Monophosphatase Transcription and Translation. Cheshire, CT: Weinder Publishing, 1999.
27. Moore CM, Breeze JL, Gruber SA et al. Choline, myoinositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disord 2000; 2: 207-216.
28. Henry SA, Donahue TF, Culbertson MR. Selection of spontaneous mutants by inositol starvation in yeast. Mol Gen Genet 1975; 143: 5-11.
29. Jackson M, Shin S. Analysis of inositol starvation in an inositol requiring mutant CHO-K1. JBC 1980; 87: 293a.
30. Minskoff SA, Gaynor PM, Greenberg ML. Mutant enrichment of Schizosaccharomyces pombe by inositol-less death. J Bacteriol 1992; 174: 4078-4085.
31. Jope RS. Anti-bipolar therapy. mechanism of action of lithium. Mol Psychiatry 1999; 4: 117-128.
32. Ikonomov OC, Manji HK. Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge. Am J Psychiatry 1999; 156: 1506-1514.
33. Agranoff BW, Fisher SK. Inositol, lithium and the brain. Psychopharmacol Bull 2001; 35: 5-23.
34. Richards MH, Belmaker RH. Epi-inositol is biochemically active in reversing lithium effects on cytidine monophosphorylphosphatidate (CMP-PA) [Short communication]. J Neural Transm 1996; 103: 1281-1285.
35. Benjamins JA, Agranoff BW. Distribution and properties of CDP-diglyceride: inositol transferase from brain. J Neurochem 1969; 16: 513-527.
36. Shaltiel G, Shamir A, Nemanov L et al. Inositol monophosphatase activity in brain and lymphocyte-derived cell lines of bipolar, schizophrenic and unipolar patients. World J Biol Psychiatry 2001; 2: 95-98.
37. Shimon H, Agam G, Belmaker RH, Hyde TM, Kleinman JE. Reduced frontal cortex inositol levels in postmortem brain of suicide victims and patients with bipolar disorder. Am J Psychiatry 1997; 154: 1148-1150.
38. Davanzo P, Thomas MA, Yue K et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 2001; 24: 359-369.
39. Shapiro J, Belmaker RH, Beigon A, Seker A, Agam G. Scyllo-inositol in post-mortem brain of suicide victims, bipolar, unipolar and schizophrenic patients. J Neural Transm 2000; 107: 603-607.
40. Soares JC, Mallinger AG, Dippold CS, Forster Wells K, Frank E, Kupfer DJ. Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study. Psychopharmacology (Berl) 2000; 149: 12-16.
41. Banks RE, Aiton JF, Cramb G, Naylor GJ. Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients. J Affect Disord 1990; 19: 1-8.
42. Nemanov L, Ebstein R, Belmaker R, Osher Y, Agam G. Effect of bibolar disorder on lymphocyte inositol monophosphatase mRNA levels. Int J Neuropsychopharmacol 1999; 2: 25-29.
43. Shamir A, Ebstein RP, Nemanov L, Zohar A, Belmaker RH, Agam G. Inositol monophosphatase in immortalized lymphoblastoid cell lines indicates susceptibility to bipolar disorder and response to lithium therapy [Letter]. Mol Psychiatry 1998; 3: 481-482.
44. Belmaker RH, Shapiro J, Vainer E, Nemanov L, Ebstein RP, Agam G. Reduced inositol content in lymphocyte-derived cell lines from bipolar patients. Bipolar Disord 2002; 4: 67-69.
45. Moore CM, Breeze JL, Kukes TJ et al. Effects of myoinositol ingestion on human brain myo-inositol levels: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry 1999; 45: 1197-1202.