The genotype of mice influences the autoimmune response to spliceosome proteins induced by cytomegalovirus gB immunization

Clinical and Experimental Immunology

Volumn 129, Issue 1, 2002, Pages 19-26

  Lipes, J ^a   Skamene, E ^a   Newkirk, M M ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

Autoantibodies; Cytomegalovirus; Spliceosome; Systemic lupus erythematosus

Indexed keywords

ANTIGEN; AUTOANTIBODY; IMMUNOGLOBULIN G; NITROGEN; PROTEIN; PROTEIN U1 70K; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; IMMUNIZATION; IMMUNOBLOTTING; KIDNEY DISEASE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN DISEASE; SPLICEOSOME; STRAIN DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; UREA NITROGEN BLOOD LEVEL;

ADENOVIRIDAE; ANIMALS; ANIMALS, CONGENIC; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; CYTOMEGALOVIRUS; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VECTORS; GENOTYPE; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; KIDNEY; LUPUS NEPHRITIS; MICE; MICE, INBRED A; MICE, INBRED C57BL; PROTEINURIA; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; SKIN; SPLICEOSOMES; VIRAL ENVELOPE PROTEINS;

EID: 0036379557     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01899.x     Document Type: Article

References (39)

1. Klein Gunnewiek JMT, van de Putte LBA, van Venrooij WJ. The U1 snRNP complex: an autoantigen in connective tissue diseases. An update. Clin Exp Rheumatol 1997; 15:549-60.
2. Hahn BH. Systemic lupus erythematosus. In: Isselbacher K, Braunwald E, Wilson J et al., eds. Harrison's, TR, Principles of internal medicine, 13th edn. New York McGraw-Hill, Inc, 1994: pp. 1643-8.
3. Lindqvist A-KB, Alarcon-Riquelme ME. The genetics of systemic lupus erythematosus. Scand J Immunol 1999; 50:562-71.
4. Kumar V, Cotran R, Robbins S, eds. Basic pathology, 6th edn. Philadelphia WB Saunders Company, 1997:102-8.
5. Talal N, Garry RF, Schur PH et al. A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus. J Clin Invest 1990; 85:1866-71.
6. Ranki A, Kurki P, Riepponen S, Stephansson E. Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies. Arthritis Rheum 1992; 35:1483-91.
7. Rider JR, Ollier WE, Lock RJ, Brookes ST, Pamphilon DH. Human cytomegalovirus infection and systemic lupus erythematosus. Clin Exp Rheumatol 1997; 15:405-9.
8. Newkirk MM, van Venrooij WJ, Marshall GS. Autoimmune response to small ribosomal nucleoprotein (RNP) linked to cytomegalovirus infection. Arthritis Res 2001; 3:253-8.
9. Bruggeman CA. Cytomegalovirus and latency: an overview. Virchows Arch B Cell Pathol Incl Mol Pathol 1993; 64:325-33.
10. Sweet C. The pathogenicity of cytomegalovirus. FEMS Microbiol Rev 1999; 23:457-82.
11. Alford CA, Britt WJ. Cytomegalovirus. In: Roizman B, Whitley RJ, Lopez C, eds. The human herpesviruses. New York: Raven Press Ltd, 1993:227-55.
12. Peckham CS. Cytomegalovirus infection. Congenital and neonatal disease. Scand J Infect Dis Suppl 1991; 18:82-7.
13. Pass RF, Duliege AM, Boppana S et al. A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J Infect Dis 1999; 180:970-5.
14. Frey SE, Harrison C, Pass RF et al. Effects of antigen dose and immunization regiments on antibody responses to a cytomegalovirus glycoprotein B subunit vaccine. J Infect Dis 1999; 180:1700-3.
15. Curtis HAE, Singh T, Newkirk MM. Recombinant cytomegalovirus glycoprotein gB (UL55) induces an autoantibody response to the U1-70 kDa small nuclear ribonucleoprotein. Eur J Immunol 1999; 29:3643-53.
16. Behar SM, Porcelli SA. Mechanisms of autoimmune disease induction. The role of the immune response to microbial pathogens. Arthritis Rheum 1995; 38:458-76.
17. James JA, Harley JB. B-cell epitope spreading in autoimmunity. Immunol Rev 1998; 164:185-200.
18. Mamula MJ. Epitope spreading. the role of self peptides and autoantigen processing by B lymphocytes. Immunol Rev 1998; 164:231-9.
19. Berencsi K, Rando RF, deTaisne C, Paoletti E, Plotkin SA, Gonczol E. Murine cytotoxic T cell response specific for human cytomegalovirus glycoprotein B (gB) induced by adenovirus and vaccinia virus recombinants expressing gB. J General Virol 1993; 74:2507-12.
20. Dorf M, Dunham EK, Johnson JP, Benacerraf B. Genetic control of the immune response: the effect of non-H-2 linked genes on antibody production. J Immunol 1974; 112:1329-36.
21. Petty RE, Steward MW, Soothill JF. The heterogeneity of antibody affinity in inbred mice and its possible immunopathologic significance. Clin Exp Immunol 1972; 12:231-41.
22. Vetvicka V, Vonkova J, Rihova B. Effect of age on antibody responses in low responder B57Bl/10ScSn and high responder A/J strains of mice. Mech Age Devpt 1993; 71:131-41.
23. Blomberg B, Geckeler WR, Weigert M. Genetics of the antibody response to dextran in mice. Science 1972; 177:178-80.
24. James JA, Harley JB. A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in mice. J Immunol 1998; 160:502-8.
25. James JA, Gross T, Scofield RH, Harley JB. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med 1995; 181:453-61.
26. Mason LJ, Timothy LM, Isenberg DA, Kalsi JK. Immunization with a peptide of Sm B/B′ results in limited epitope spreading but not autoimmune disease. J Immunol 1999; 162:5099-105.
27. Spaete RR, Thayer RM, Probert WS et al. Human cytomegalovirus strain Towne glycoprotein B is processed by proteolytic cleavage. Virology 1988; 167:207-24.
28. Hornig H, Fischer U, Costas M, Rauh A, Luhrmann A. Analysis of genomic clones of the murine U1RNA-associated 70-kDa protein reveals a high evolutionary conservation of the protein between human and mouse. Eur J Biochem 1989; 182:45-50.
29. Craft J. Anti-snRNP antibodies. In: Wallace DL, Hahn BH, eds. Dubois' lupus erythematosus, 5th edn. Baltimore: Williams & Wilkins, 1997:457-70.
30. ter Borg EJ, Groen H, Horst G, Limburg PC, Wouda AA, Kallenberg GCM. Clinical associations of anti ribonucleoprotein antibodies in patients with systemic lupus erythematosus. Semin Arthritis Rheum 1990; 20:164-73.
31. Homma M, Mimori T, Takeda Y et al. Autoantibodies to the Sm antigen: immunological approach to clinical aspects of systemic lupus erythematosus. J Rheumatol 1987; 14:188-93.
32. Madaio MP. The role of autoantibodies in the pathogenesis of lupus nephritis. Semin Nephrol 1999; 19:48-56.
33. Foster MH, Kelley VR. Lupus nephritis: update on pathogenesis and disease mechanisms. Semin Nephrol 1999; 19:173-81.
34. Kimura M, Takahasi H, Ohtake T et al. Interstrain differences in murine daunomycin-induced nephrosis. Nephron 1993; 63:193-8.
35. Hultman P, Bell LJ, Enestrom S, Pollard KM. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin Immunol Immunopathol 1992; 65:98-109.
36. Tucker RM, Vyse TJ, Rozzo S, Roark CL, Izui S, Kotzin BL. Genetic control of glycoprotein 70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus. J Immunol 2000; 165:1665-72.
37. Morel L, Croker BP, Blenmen KR et al. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA 2000; 97:6670-5.
38. Sutmuller M, Ekstijn GL, Ouellette S, De Heer E, Bruijn JA. Non-MHC genes determine the development of lupus nephritis in H-2 identical mouse strains. Clin Exp Immunol 1996; 106:265-72.
39. Clynes R, Dumitru C, Ravetch JV. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998; 279:1052-4.