Bioinformatics: From genome to drug targets

Annals of Medicine

Volumn 34, Issue 4, 2002, Pages 306-312

  Dahl, Svein G ^a   Kristiansen, Kurt ^a   Sylte, Ingebrigt ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Bioinformatics; Drug targets; Drug receptor interactions; Membrane proteins; Molecular dynamics; Molecular mechanisms; Molecular modelling; Three dimensional protein structure

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GENE PRODUCT; ION CHANNEL; MEMBRANE PROTEIN; NEUROTRANSMITTER;

ARTICLE; BIOINFORMATICS; DRUG TARGETING; GENE EXPRESSION; GENOME; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; X RAY DIFFRACTION;

COMPUTATIONAL BIOLOGY; GENOME; GENOMICS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS;

EID: 0036377939     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.1080/078538902320322574     Document Type: Article

References (42)

1. Langley JN. On nerve endings and on special exitable substances in cells. Proc R Soc Lond B Biol Sci 1906; B78: 170-94.
2. Langley JN. On the contraction of muscle, chiefly in relation to the presence of "receptive" substances. Part IV. The effect of curari and of some other substances on the nicotine response of the sartorius and gastrocnemius muscles of the frog. J Physiol 1909; 39: 235-95.
3. Clark AJ. 1933 The mode of action of drugs on cells. London, E. Arnold.
4. Noda M, Takahashi H, Tanabe T, Toyosato M, Furutani Y, Hirose T, et al. Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 1982; 299: 793-7.
5. Noda M, Takahashi H, Tanabe T, Toyosato M, Kikyotani S, Hirose T, et al. Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature 1983; 301: 251-5.
6. Noda M, Takahashi H, Tanabe T, Toyosato M, Kikyotani S, Furutani Y, et al. Structural homology of Torpedo californica acetylcholine receptor subunits. Nature 1983; 302: 528-32.
7. Numa S, Noda M, Takahashi H, Tanabe T, Toyosato M, Furutani Y, et al. Molecular structure of the nicotinic acetylcholine receptor. Cold Spring Harb Symp Quant Biol 1983; 48: 57-69.
8. Drews J. Drug discovery: a historical perspective. Science 2000; 287: 1960-4.
9. Deisenhofer J, Epp O, Miki K, Huber R, Michel H. X-ray structure analysis of a membrane protein complex. Electron density map at 3 Å resolution and a model of the chromophores of the photosynthetic reaction center from Rhodopseudomonas viridis. J Mol Biol 1984; 180: 385-98.
10. Deisenhofer J, Epp O, Miki K, Huber R, Michel H. Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution. Nature 1985; 318: 618-24.
11. Abbott A. Computer modellers seek out 'Ten Most Wanted' proteins. Nature 2001; 409: 4.
12. Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 2000; 21: 90-113.
13. Birnbaumer L, Abramowitz J, Brown AM. Receptor-effector coupling by G proteins. Biochim Biophys Acta 1990; 1031: 163-224.
14. Perez DM, Hwa J, Gaivin R, Mathur M, Brown F, Graham RM. Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. Mol Pharmacol 1996; 49: 112-22.
15. Albert PR, Sajedi N, Lemonde S, Ghahremani MH. Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists. J Biol Chem 1999; 274: 35469-74.
16. Sidhu A, Niznik HB. Coupling of dopamine receptor subtypes to multiple and diverse G proteins. Int J Dev Neurosci 2000; 18: 669-77.
17. Samama P, Cotecchia S, Costa T, Lefkowitz RJ. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 1993; 268: 4625-36.
18. Claeysen S, Sebben M, Becamel C, Eglen RM, Clark RD, Bockaert J, et al. Pharmacological properties of 5-Hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors. Mol Pharmacol 2000; 58: 136-44.
19. Shapiro DA, Kristiansen K, Weiner DM, Kroeze WK, Roth BL. Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. J Biol Chem 2002; 277: 11441-9.
20. Milligan G, Bond RA, Lee M. Inverse agonism: pharmacological curiosity or potential therapeutic strategy? Trends Pharmacol Sci 1995; 16: 10-3.
21. Spiegel AM. Defects in G protein-coupled signal transduction in human disease. Annu Rev Physiol 1996; 58: 143-70.
22. Rana BK, Shiina T, Insel PA. Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. Annu Rev Pharmacol Toxicol 2001; 41: 593-624.
23. Reizer J, Reizer A, Saier MH, Jr. A functional superfamily of sodium/solute symporters. Biochim Biophys Acta 1994; 1197: 133-66.
24. Chen JG, Liu-Chen S, Rudnick G. Determination of external loop topology in the serotonin transporter by site-directed chemical labeling. J Biol Chem 1998; 273: 12675-81.
25. Williams KA. Three-dimensional structure of the ion-coupled transport protein NhaA. Nature 2000; 403: 112-5.
26. Ravna AW, Sylte I, Dahl SG. Molecular model of the Echerichia coli Na+/H+ antiporter NhaA. Receptors Channels 2001; 7: 319-28.
27. Ravna AW, Sylte I, Dahl SG. Molecular model of the dopamine transporter protein. (submitted).
28. Chang G, Roth CB. Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 2001; 293: 1793-800.
29. + conduction and selectivity. Science 1998; 280: 69-77.
30. + channel and demonstration of its presence in the human BK channel. Neuron 2001; 29: 593-601.
31. Sylte I, Bronowska A, Dahl SG. Ligand induced conformational states of the 5-HT1A receptor. Eur J Pharmacol 2001; 416: 33-41.
32. Anfinsen CB. Principles that govern the folding of protein chains. Science 1973; 181: 223-30.
33. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, et al. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000; 289: 739-45.
34. Unger VM, Hargrave PA, Baldwin JM, Schertler GF. Arrangement of rhodopsin transmembrane alpha-helices. Nature 1997; 389: 203-6.
35. Baldwin JM, Schertler GF, Unger VM. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J Mol Biol 1997; 272: 144-64.
36. Dahl SG, Edvardsen O, Kristiansen K, Sylte I. Bioinformatics and receptor mechanisms of psychotropic drugs. Biotechnol Annu Rev 2001; 7: 165-77.
37. Kaback HR, Wu J. From membrane to molecule to the third amino acid from the left with a membrane transport protein. Q Rev Biophys 1997; 30: 333-64.
38. Higgins CF, Linton KJ. Structural biology. The xyz of ABC transporters. Science 2001, 293: 1782-4.
39. Edvardsen O, Reiersen AL, Beukers MW, Kristiansen K. tGRAP, the G-protein coupled receptors mutant database. Nucleic Acids Res 2002; 30: 361-3.
40. Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, et al. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 2000; 407: 971-7.
41. Armstrong N, Sun Y, Chen GQ, Gouaux E. Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 1998; 395: 913-7.
42. Yaspo ML. Taking a functional genomics approach in molecular medicine. Trends Mol Med 2001; 1: 494-501.